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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for CREB3L1_CREB3
Z-value: 1.15
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Transcription factors associated with CREB3L1_CREB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3 | hg38_v1_chr9_+_35732649_35732685 | 0.70 | 1.1e-04 | Click! |
| CREB3L1 | hg38_v1_chr11_+_46277648_46277686 | 0.44 | 3.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L1_CREB3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.9 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.7 | 3.0 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.2 | 2.9 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.1 | 2.5 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 2.3 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.0 | 2.3 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.4 | 2.1 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.2 | 2.0 | GO:0070862 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.1 | 1.9 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.1 | 1.9 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 2.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 2.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 1.5 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.4 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 1.2 | GO:0097413 | Lewy body(GO:0097413) |
| 0.1 | 1.1 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.1 | 1.1 | GO:0043083 | synaptic cleft(GO:0043083) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.4 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 0.1 | 3.0 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 2.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 2.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.6 | 2.5 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.3 | 1.9 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.1 | 1.9 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.4 | 1.8 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.2 | 1.8 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 1.8 | GO:0070567 | cytidylyltransferase activity(GO:0070567) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 2.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 1.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.7 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 3.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 2.0 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 2.0 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.1 | 1.6 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 1.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 1.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 1.5 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |