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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for CREB5_CREM_JUNB
Z-value: 1.18
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Transcription factors associated with CREB5_CREM_JUNB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREM | hg38_v1_chr10_+_35195843_35196009 | 0.77 | 8.3e-06 | Click! |
| JUNB | hg38_v1_chr19_+_12791470_12791494 | 0.35 | 8.6e-02 | Click! |
| CREB5 | hg38_v1_chr7_+_28412511_28412536 | -0.30 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.2 | 11.3 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.1 | 6.8 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.1 | 6.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.2 | 6.0 | GO:0051447 | negative regulation of meiotic cell cycle(GO:0051447) |
| 1.1 | 4.6 | GO:0021571 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.2 | 4.6 | GO:0060211 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.3 | 4.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.3 | 3.6 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.6 | 2.9 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.9 | 7.3 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 4.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 3.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 3.0 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 3.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.9 | 2.8 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.0 | 2.8 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 2.2 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 2.1 | GO:0031673 | H zone(GO:0031673) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 17.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 9.1 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.1 | 7.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 4.5 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 1.4 | 4.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 4.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.2 | 3.7 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.4 | 3.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 3.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 3.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 4.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 3.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 2.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 1.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.5 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.2 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 3.2 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 2.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.6 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 2.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 2.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |