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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for DBP
Z-value: 1.26
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Transcription factors associated with DBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DBP | hg38_v1_chr19_-_48634526_48634636 | 0.62 | 9.2e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBP
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 7.9 | GO:0007286 | spermatid development(GO:0007286) |
| 0.2 | 7.4 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.2 | 7.0 | GO:0060023 | soft palate development(GO:0060023) |
| 1.5 | 6.0 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.1 | 6.0 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.1 | 5.5 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.7 | 5.0 | GO:0021593 | rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658) |
| 0.1 | 4.3 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.4 | 3.9 | GO:0034350 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 8.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 5.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 5.3 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 5.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 4.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 3.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.2 | 3.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 3.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.3 | 2.7 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 8.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.6 | 7.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 7.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 6.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 5.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 4.5 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.2 | 4.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 1.0 | 4.0 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.6 | 3.9 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 13.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 9.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 5.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 3.3 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 2.7 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.5 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 2.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 4.4 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 3.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 3.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 3.4 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 3.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 2.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 2.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |