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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for DDIT3

Z-value: 0.46

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.13 DDIT3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg38_v1_chr12_-_57520480_57520521-0.058.0e-01Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_33892010 2.00 ENST00000257818.3
LMO2
LIM domain only 2
chr10_-_114684457 1.79 ENST00000392955.7
ABLIM1
actin binding LIM protein 1
chr13_+_32031706 1.67 ENST00000542859.6
FRY
FRY microtubule binding protein
chr10_-_114684612 1.63 ENST00000533213.6
ENST00000369252.8
ABLIM1
actin binding LIM protein 1
chr1_+_61203496 1.38 ENST00000663597.1
NFIA
nuclear factor I A
chr8_-_92017637 1.09 ENST00000422361.6
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr2_-_43226594 1.08 ENST00000282388.4
ZFP36L2
ZFP36 ring finger protein like 2
chr4_-_98657635 0.97 ENST00000515287.5
ENST00000511651.5
ENST00000505184.5
TSPAN5
tetraspanin 5
chr2_-_182242031 0.91 ENST00000358139.6
PDE1A
phosphodiesterase 1A
chr3_+_37975773 0.86 ENST00000436654.1
CTDSPL
CTD small phosphatase like
chr5_-_140633167 0.83 ENST00000302014.11
CD14
CD14 molecule
chr12_-_24949026 0.76 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr12_+_103930600 0.66 ENST00000680316.1
ENST00000679861.1
HSP90B1
heat shock protein 90 beta family member 1
chr17_-_37542361 0.65 ENST00000614196.1
SYNRG
synergin gamma
chr17_+_58238426 0.56 ENST00000421678.6
ENST00000262290.9
ENST00000543544.5
LPO
lactoperoxidase
chr22_+_31122923 0.56 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chrX_+_30235894 0.48 ENST00000620842.1
MAGEB3
MAGE family member B3
chr12_-_12338674 0.45 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr2_-_215436061 0.42 ENST00000421182.5
ENST00000432072.6
ENST00000323926.10
ENST00000336916.8
ENST00000357867.8
ENST00000359671.5
ENST00000446046.5
ENST00000354785.11
ENST00000356005.8
ENST00000443816.5
ENST00000426059.1
FN1
fibronectin 1
chr6_-_31897200 0.41 ENST00000395728.7
ENST00000375528.8
EHMT2
euchromatic histone lysine methyltransferase 2
chr4_+_157076119 0.40 ENST00000541722.5
ENST00000264428.9
ENST00000512619.5
GLRB
glycine receptor beta
chr7_-_99408548 0.40 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chrX_+_52495791 0.37 ENST00000375602.2
ENST00000375600.5
XAGE1A
X antigen family member 1A
chr3_+_15601969 0.35 ENST00000436193.5
ENST00000383778.5
BTD
biotinidase
chr10_-_17617235 0.35 ENST00000466335.1
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr10_-_17617326 0.32 ENST00000326961.6
ENST00000361271.8
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr19_+_10625507 0.32 ENST00000590857.5
ENST00000588688.5
ENST00000586078.5
ENST00000335757.10
SLC44A2
solute carrier family 44 member 2
chr3_-_56468346 0.30 ENST00000288221.11
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr10_+_100997040 0.29 ENST00000370223.7
LZTS2
leucine zipper tumor suppressor 2
chr7_-_44490609 0.28 ENST00000355451.8
NUDCD3
NudC domain containing 3
chr11_+_47257953 0.27 ENST00000437276.1
ENST00000436029.5
ENST00000467728.5
ENST00000441012.7
ENST00000405853.7
NR1H3
nuclear receptor subfamily 1 group H member 3
chr7_+_90469634 0.26 ENST00000509356.2
PTTG1IP2
PTTG1IP family member 2
chr3_-_9553796 0.24 ENST00000287585.8
LHFPL4
LHFPL tetraspan subfamily member 4
chr14_+_101809795 0.24 ENST00000350249.7
ENST00000557621.5
ENST00000556946.1
PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
chr2_-_207769889 0.22 ENST00000295417.4
FZD5
frizzled class receptor 5
chr15_-_63833911 0.22 ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
ENST00000443617.7
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr11_+_114296347 0.22 ENST00000299964.4
NNMT
nicotinamide N-methyltransferase
chrX_-_52517213 0.22 ENST00000375616.5
XAGE1B
X antigen family member 1B
chr14_+_101809855 0.22 ENST00000557714.1
ENST00000445439.7
ENST00000334743.9
ENST00000557095.5
PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
chr19_-_6459735 0.21 ENST00000334510.9
ENST00000301454.9
SLC25A23
solute carrier family 25 member 23
chrX_-_134658450 0.21 ENST00000359237.9
PLAC1
placenta enriched 1
chr11_-_10294194 0.19 ENST00000676387.1
ENST00000256190.13
ENST00000675281.1
SBF2
SET binding factor 2
chr20_-_33004307 0.19 ENST00000420875.5
ENST00000375519.2
ENST00000375523.7
ENST00000356173.8
SUN5
Sad1 and UNC84 domain containing 5
chr3_+_186613052 0.18 ENST00000411641.7
ENST00000273784.5
AHSG
alpha 2-HS glycoprotein
chr9_+_109780179 0.18 ENST00000314527.9
PALM2AKAP2
PALM2 and AKAP2 fusion
chr5_+_119476530 0.17 ENST00000645099.1
ENST00000513628.5
HSD17B4
hydroxysteroid 17-beta dehydrogenase 4
chr14_-_73760259 0.17 ENST00000286523.9
ENST00000435371.1
MIDEAS
mitotic deacetylase associated SANT domain protein
chr15_+_85380672 0.17 ENST00000361243.6
ENST00000560256.1
AKAP13
A-kinase anchoring protein 13
chr5_-_67196791 0.15 ENST00000256447.5
CD180
CD180 molecule
chr5_+_168529299 0.15 ENST00000338333.5
FBLL1
fibrillarin like 1
chr10_+_102226293 0.15 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chr10_-_102114935 0.15 ENST00000361198.9
LDB1
LIM domain binding 1
chr1_+_111227699 0.13 ENST00000369748.9
CHI3L2
chitinase 3 like 2
chr7_-_56034133 0.13 ENST00000421626.5
PSPH
phosphoserine phosphatase
chr17_-_49848017 0.13 ENST00000326219.5
ENST00000334568.8
ENST00000352793.6
ENST00000398154.5
ENST00000436235.5
TAC4
tachykinin precursor 4
chr1_+_111227610 0.13 ENST00000369744.6
CHI3L2
chitinase 3 like 2
chr6_+_31927486 0.13 ENST00000442278.6
C2
complement C2
chr19_+_12806550 0.13 ENST00000221486.6
RNASEH2A
ribonuclease H2 subunit A
chr7_+_44000889 0.12 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr4_-_152679984 0.12 ENST00000304385.8
ENST00000504064.1
TMEM154
transmembrane protein 154
chr14_+_21797272 0.12 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr8_-_92017292 0.12 ENST00000521553.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr4_+_140257286 0.12 ENST00000394205.7
SCOC
short coiled-coil protein
chr13_-_45341086 0.11 ENST00000309246.9
ENST00000379060.8
ENST00000379055.5
ENST00000527226.2
ENST00000530705.6
ENST00000379056.5
ENST00000616577.4
TPT1
tumor protein, translationally-controlled 1
chr12_-_52680398 0.11 ENST00000252244.3
KRT1
keratin 1
chr17_+_4433904 0.10 ENST00000355530.7
SPNS3
sphingolipid transporter 3 (putative)
chr9_+_109780312 0.10 ENST00000483909.5
ENST00000413420.5
ENST00000302798.7
PALM2AKAP2
PALM2 and AKAP2 fusion
chr11_-_69704013 0.10 ENST00000294312.4
FGF19
fibroblast growth factor 19
chr1_+_33081145 0.10 ENST00000294517.11
ENST00000373443.7
AZIN2
antizyme inhibitor 2
chr18_-_57621741 0.09 ENST00000587194.1
ENST00000591599.5
ENST00000588661.5
ENST00000256854.10
NARS1
asparaginyl-tRNA synthetase 1
chr6_-_157323498 0.09 ENST00000400788.9
ENST00000367144.4
TMEM242
transmembrane protein 242
chr6_+_167999092 0.08 ENST00000443060.6
KIF25
kinesin family member 25
chr21_-_30492008 0.08 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr19_-_6604083 0.08 ENST00000597430.2
CD70
CD70 molecule
chr1_-_206970457 0.08 ENST00000324852.9
ENST00000450945.3
ENST00000400962.8
FCAMR
Fc fragment of IgA and IgM receptor
chr1_-_19923617 0.07 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr7_-_138679045 0.07 ENST00000419765.4
SVOPL
SVOP like
chr3_-_45842066 0.05 ENST00000445698.1
ENST00000296135.11
LZTFL1
leucine zipper transcription factor like 1
chr1_-_44355061 0.05 ENST00000649995.1
ENST00000457571.1
ENST00000372257.7
ENST00000452396.5
ERI3
ERI1 exoribonuclease family member 3
chrX_-_139642518 0.05 ENST00000370573.8
ENST00000338585.6
MCF2
MCF.2 cell line derived transforming sequence
chr2_+_63588953 0.04 ENST00000409908.5
ENST00000442225.5
ENST00000233114.13
ENST00000539945.7
ENST00000409476.5
ENST00000436321.5
MDH1
malate dehydrogenase 1
chr5_-_178590367 0.04 ENST00000390654.8
COL23A1
collagen type XXIII alpha 1 chain
chr22_-_30505650 0.03 ENST00000381982.3
ENST00000255858.12
SEC14L4
SEC14 like lipid binding 4
chr20_+_56412249 0.03 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chr6_+_31897775 0.02 ENST00000469372.5
ENST00000497706.5
C2
complement C2
chr21_-_44914271 0.02 ENST00000522931.5
ITGB2
integrin subunit beta 2
chr4_+_183659267 0.02 ENST00000357207.8
ENST00000334690.11
TRAPPC11
trafficking protein particle complex 11
chr8_+_26577843 0.02 ENST00000311151.9
DPYSL2
dihydropyrimidinase like 2
chr18_-_63158208 0.02 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr5_+_141364153 0.02 ENST00000518069.2
PCDHGA5
protocadherin gamma subfamily A, 5
chr15_+_85380565 0.02 ENST00000559362.5
ENST00000394518.7
AKAP13
A-kinase anchoring protein 13
chr5_+_141364231 0.02 ENST00000611914.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr12_-_109309218 0.01 ENST00000355216.5
FOXN4
forkhead box N4
chr12_-_62935117 0.01 ENST00000228705.7
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent 1H
chr11_+_18602969 0.01 ENST00000636011.1
ENST00000542172.1
SPTY2D1OS
SPTY2D1 opposite strand
chrX_-_139642835 0.01 ENST00000536274.5
MCF2
MCF.2 cell line derived transforming sequence
chr16_-_70289480 0.01 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr20_+_56412393 0.00 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr12_-_109309278 0.00 ENST00000299162.10
FOXN4
forkhead box N4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.2 0.7 GO:0031247 actin rod assembly(GO:0031247)
0.2 0.8 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.2 0.8 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.4 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 1.1 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.4 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.1 0.3 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.1 2.0 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.2 GO:0097274 urea homeostasis(GO:0097274)
0.1 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.2 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.1 0.2 GO:0097360 Spemann organizer formation(GO:0060061) chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.1 0.2 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.1 GO:0000494 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 1.4 GO:0072189 ureter development(GO:0072189)
0.0 0.8 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0015847 putrescine transport(GO:0015847) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.0 3.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.2 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 1.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.2 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.3 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.4 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 0.4 GO:0006768 biotin metabolic process(GO:0006768)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.5 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 3.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
0.2 0.8 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.9 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.8 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.4 GO:0047708 biotinidase activity(GO:0047708)
0.1 0.4 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.2 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.1 0.6 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.3 GO:0032810 sterol response element binding(GO:0032810)
0.1 1.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0015489 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
0.0 2.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.4 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane