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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for DMBX1

Z-value: 0.38

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.11 DMBX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg38_v1_chr1_+_46489800_46489842-0.367.6e-02Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_44680875 0.93 ENST00000649279.2
ENST00000677699.1
SETBP1
SET binding protein 1
chr4_+_139665768 0.70 ENST00000616265.4
ENST00000265498.6
ENST00000506797.5
MGST2
microsomal glutathione S-transferase 2
chr3_-_138132381 0.65 ENST00000236709.4
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr2_-_70553440 0.48 ENST00000450929.5
TGFA
transforming growth factor alpha
chr12_-_56333893 0.40 ENST00000547572.1
ENST00000257931.9
ENST00000610546.4
ENST00000440411.7
PAN2
poly(A) specific ribonuclease subunit PAN2
chr19_+_45498439 0.39 ENST00000451287.7
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chrX_-_103311004 0.39 ENST00000372674.5
BEX2
brain expressed X-linked 2
chr10_+_102226293 0.38 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chr12_-_56333693 0.35 ENST00000425394.7
ENST00000548043.5
PAN2
poly(A) specific ribonuclease subunit PAN2
chr6_+_130018565 0.34 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr16_-_3372666 0.34 ENST00000399974.5
MTRNR2L4
MT-RNR2 like 4
chr11_+_121576760 0.34 ENST00000532694.5
ENST00000534286.5
SORL1
sortilin related receptor 1
chr3_-_49021045 0.33 ENST00000440857.5
DALRD3
DALR anticodon binding domain containing 3
chr1_-_165445088 0.30 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr1_-_165445220 0.30 ENST00000619224.1
RXRG
retinoid X receptor gamma
chr4_-_53365976 0.29 ENST00000401642.8
ENST00000388940.8
ENST00000503450.1
SCFD2
sec1 family domain containing 2
chr17_+_4740042 0.28 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr17_+_4740005 0.28 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr19_-_6459735 0.28 ENST00000334510.9
ENST00000301454.9
SLC25A23
solute carrier family 25 member 23
chr19_+_40778216 0.27 ENST00000594800.5
ENST00000357052.8
ENST00000602173.5
RAB4B
RAB4B, member RAS oncogene family
chr3_-_149576203 0.27 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr3_+_136930469 0.25 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr12_+_53300027 0.24 ENST00000549488.5
MYG1
MYG1 exonuclease
chr3_-_121749704 0.24 ENST00000393667.7
ENST00000340645.9
ENST00000614479.4
GOLGB1
golgin B1
chr18_-_55587335 0.23 ENST00000638154.3
TCF4
transcription factor 4
chr1_+_19882374 0.22 ENST00000375120.4
OTUD3
OTU deubiquitinase 3
chr4_-_169757873 0.22 ENST00000393381.3
HPF1
histone PARylation factor 1
chr12_-_10807286 0.22 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr12_-_118190510 0.19 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr10_-_99732070 0.18 ENST00000370483.9
ENST00000016171.6
COX15
cytochrome c oxidase assembly homolog COX15
chr7_+_1688119 0.18 ENST00000424383.4
ELFN1
extracellular leucine rich repeat and fibronectin type III domain containing 1
chr15_-_60479080 0.17 ENST00000560072.5
ENST00000560406.5
ENST00000560520.1
ENST00000261520.9
ICE2
interactor of little elongation complex ELL subunit 2
chr12_-_54981838 0.16 ENST00000316577.12
TESPA1
thymocyte expressed, positive selection associated 1
chr6_+_42746958 0.16 ENST00000614467.4
BICRAL
BRD4 interacting chromatin remodeling complex associated protein like
chr17_+_50834581 0.15 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr3_+_138621225 0.14 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr4_+_625555 0.14 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chr17_-_4739866 0.14 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chrX_-_32155462 0.14 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
DMD
dystrophin
chr2_-_207624983 0.13 ENST00000448007.6
ENST00000432416.5
ENST00000411432.5
ENST00000458426.5
ENST00000406927.6
ENST00000425132.5
METTL21A
methyltransferase like 21A
chr19_-_50637939 0.12 ENST00000338916.8
SYT3
synaptotagmin 3
chr19_-_17075418 0.12 ENST00000253669.10
HAUS8
HAUS augmin like complex subunit 8
chr3_-_19934189 0.11 ENST00000295824.14
EFHB
EF-hand domain family member B
chr19_-_17075038 0.11 ENST00000593360.1
HAUS8
HAUS augmin like complex subunit 8
chr19_-_42412347 0.11 ENST00000601189.1
ENST00000599211.1
LIPE
lipase E, hormone sensitive type
chrX_-_15854791 0.11 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr1_+_121184964 0.10 ENST00000367123.8
SRGAP2C
SLIT-ROBO Rho GTPase activating protein 2C
chr21_-_33643926 0.10 ENST00000438788.1
CRYZL1
crystallin zeta like 1
chr1_-_145095528 0.10 ENST00000612199.4
ENST00000641863.1
SRGAP2B
SLIT-ROBO Rho GTPase activating protein 2B
chr17_-_19748341 0.09 ENST00000395555.7
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_19748285 0.09 ENST00000570414.1
ENST00000225740.11
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr3_-_149752443 0.09 ENST00000473414.6
COMMD2
COMM domain containing 2
chr17_-_19748355 0.09 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr3_-_196515315 0.09 ENST00000397537.3
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr1_-_121184292 0.09 ENST00000452190.2
ENST00000619376.4
ENST00000369390.7
FAM72B
family with sequence similarity 72 member B
chr1_-_143971965 0.09 ENST00000369175.4
ENST00000584486.6
FAM72C
family with sequence similarity 72 member C
chr1_-_206202827 0.08 ENST00000431655.2
ENST00000367128.8
FAM72A
family with sequence similarity 72 member A
chr13_-_61427849 0.08 ENST00000409186.1
ENST00000472649.2
ENSG00000197991.11
LINC02339
novel protein
long intergenic non-protein coding RNA 2339
chr1_+_206203541 0.08 ENST00000573034.8
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr15_-_61229297 0.08 ENST00000335670.11
RORA
RAR related orphan receptor A
chr3_+_138621207 0.08 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr8_-_100145802 0.08 ENST00000428847.3
FBXO43
F-box protein 43
chr1_+_145095967 0.07 ENST00000400889.3
FAM72D
family with sequence similarity 72 member D
chr7_-_135728177 0.07 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr18_-_24272179 0.07 ENST00000399443.7
OSBPL1A
oxysterol binding protein like 1A
chr5_+_176313080 0.06 ENST00000332772.4
SIMC1
SUMO interacting motifs containing 1
chr11_-_130916437 0.06 ENST00000533214.1
ENST00000528555.5
ENST00000530356.5
ENST00000265909.9
SNX19
sorting nexin 19
chr14_-_106875069 0.06 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr1_-_13347134 0.05 ENST00000334600.7
PRAMEF14
PRAME family member 14
chr10_+_116427839 0.05 ENST00000369230.4
PNLIPRP3
pancreatic lipase related protein 3
chr14_-_21022817 0.05 ENST00000554104.5
NDRG2
NDRG family member 2
chr5_-_140564245 0.05 ENST00000412920.7
ENST00000511201.2
ENST00000354402.9
ENST00000356738.6
APBB3
amyloid beta precursor protein binding family B member 3
chr7_+_29122274 0.04 ENST00000582692.2
ENST00000644824.1
ENSG00000285412.1
ENSG00000285162.1
novel transcript, antisense to CPVL
chimerin 2
chr19_+_17337539 0.04 ENST00000324894.13
ENST00000358792.11
ENST00000600625.5
GTPBP3
GTP binding protein 3, mitochondrial
chr15_+_81182579 0.03 ENST00000302987.9
IL16
interleukin 16
chr12_-_55927865 0.03 ENST00000454792.2
ENST00000408946.7
PYM1
PYM homolog 1, exon junction complex associated factor
chr1_-_12898270 0.03 ENST00000235347.4
PRAMEF10
PRAME family member 10
chr1_-_16237146 0.03 ENST00000375599.8
CPLANE2
ciliogenesis and planar polarity effector 2
chr17_+_9825906 0.02 ENST00000262441.10
GLP2R
glucagon like peptide 2 receptor
chr3_+_49021071 0.02 ENST00000395458.6
NDUFAF3
NADH:ubiquinone oxidoreductase complex assembly factor 3
chr9_-_21995262 0.02 ENST00000494262.5
CDKN2A
cyclin dependent kinase inhibitor 2A
chr17_+_70104848 0.02 ENST00000392670.5
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr14_+_21797272 0.02 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr1_-_47190013 0.01 ENST00000294338.7
PDZK1IP1
PDZK1 interacting protein 1
chr20_+_35968566 0.01 ENST00000373973.7
ENST00000349339.5
ENST00000489667.1
ENST00000538900.1
CNBD2
cyclic nucleotide binding domain containing 2
chr7_+_21543020 0.01 ENST00000409508.8
ENST00000620169.4
ENST00000328843.10
DNAH11
dynein axonemal heavy chain 11
chr19_-_5286163 0.01 ENST00000592099.5
ENST00000588012.5
ENST00000262963.10
ENST00000587303.5
ENST00000590509.5
PTPRS
protein tyrosine phosphatase receptor type S
chr6_-_138572523 0.01 ENST00000427025.6
NHSL1
NHS like 1
chr8_-_109644766 0.00 ENST00000533065.5
ENST00000276646.14
SYBU
syntabulin
chr18_-_72865680 0.00 ENST00000397929.5
NETO1
neuropilin and tolloid like 1
chr19_-_51034840 0.00 ENST00000529888.5
KLK12
kallikrein related peptidase 12
chr19_-_51034892 0.00 ENST00000319590.8
ENST00000250351.4
KLK12
kallikrein related peptidase 12

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1902771 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.3 GO:0097274 urea homeostasis(GO:0097274)
0.1 0.2 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.2 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.1 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.2 GO:0044313 protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167)
0.0 0.2 GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.2 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.4 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.3 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0031251 PAN complex(GO:0031251)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0035363 histone locus body(GO:0035363)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.7 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.3 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA