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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for DMC1

Z-value: 0.50

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.10 DMC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg38_v1_chr22_-_38570167_385702040.213.2e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_76023489 3.22 ENST00000306602.3
CXCL10
C-X-C motif chemokine ligand 10
chr4_+_153684241 1.60 ENST00000646219.1
ENST00000642580.1
ENST00000643501.1
ENST00000642700.2
TLR2
toll like receptor 2
chr17_+_79022908 1.20 ENST00000354124.7
ENST00000580454.5
C1QTNF1
C1q and TNF related 1
chr17_+_79022814 1.04 ENST00000578229.5
C1QTNF1
C1q and TNF related 1
chr14_+_21057822 0.72 ENST00000308227.2
RNASE8
ribonuclease A family member 8
chrX_-_64230600 0.55 ENST00000362002.3
ASB12
ankyrin repeat and SOCS box containing 12
chr11_+_134331874 0.50 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr6_-_131701401 0.49 ENST00000315453.4
OR2A4
olfactory receptor family 2 subfamily A member 4
chr3_+_101827982 0.47 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKBIZ
NFKB inhibitor zeta
chr2_-_162152404 0.46 ENST00000375497.3
GCG
glucagon
chr5_-_36301883 0.46 ENST00000502994.5
ENST00000515759.5
ENST00000296604.8
RANBP3L
RAN binding protein 3 like
chr17_+_32991844 0.46 ENST00000269053.8
SPACA3
sperm acrosome associated 3
chr10_-_73096850 0.45 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr3_-_108953870 0.45 ENST00000261047.8
GUCA1C
guanylate cyclase activator 1C
chr11_+_71527267 0.44 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chr2_+_200308943 0.43 ENST00000619961.4
SPATS2L
spermatogenesis associated serine rich 2 like
chr10_-_73096974 0.40 ENST00000440381.5
ENST00000263556.3
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr3_-_108953762 0.39 ENST00000393963.7
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr7_+_143222037 0.38 ENST00000408947.4
TAS2R40
taste 2 receptor member 40
chr2_+_186590022 0.37 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr3_+_98353854 0.35 ENST00000354924.2
OR5K4
olfactory receptor family 5 subfamily K member 4
chr15_-_42156590 0.29 ENST00000397272.7
PLA2G4F
phospholipase A2 group IVF
chr21_-_44928824 0.28 ENST00000355153.8
ENST00000397850.6
ITGB2
integrin subunit beta 2
chr10_-_60572599 0.27 ENST00000503366.5
ANK3
ankyrin 3
chr7_-_22500152 0.26 ENST00000406890.6
ENST00000678116.1
ENST00000424363.5
STEAP1B
STEAP family member 1B
chr7_+_144070313 0.26 ENST00000641441.1
OR2A25
olfactory receptor family 2 subfamily A member 25
chr10_-_102837406 0.25 ENST00000369887.4
ENST00000638272.1
ENST00000639393.1
ENST00000638971.1
ENST00000638190.1
CYP17A1
cytochrome P450 family 17 subfamily A member 1
chr18_-_5396265 0.24 ENST00000579951.2
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr11_-_86069043 0.23 ENST00000532317.5
ENST00000528256.1
ENST00000393346.8
ENST00000526033.5
PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_+_26383090 0.23 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chr1_+_9539431 0.22 ENST00000302692.7
SLC25A33
solute carrier family 25 member 33
chr2_-_18560616 0.21 ENST00000381249.4
RDH14
retinol dehydrogenase 14
chr19_+_11355386 0.20 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
PLPPR2
phospholipid phosphatase related 2
chr6_+_26383176 0.19 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chrX_-_135171398 0.19 ENST00000276241.11
ENST00000344129.2
CT55
cancer/testis antigen 55
chr2_-_85414039 0.19 ENST00000447219.6
ENST00000409670.5
ENST00000409724.5
CAPG
capping actin protein, gelsolin like
chr11_-_62921339 0.19 ENST00000306960.4
CHRM1
cholinergic receptor muscarinic 1
chr22_+_20116099 0.18 ENST00000430524.6
RANBP1
RAN binding protein 1
chr5_+_95391361 0.18 ENST00000283357.10
FAM81B
family with sequence similarity 81 member B
chr7_-_5970632 0.18 ENST00000455618.2
ENST00000405415.5
ENST00000404406.5
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B
chr6_-_31702946 0.17 ENST00000440843.2
ABHD16A
abhydrolase domain containing 16A, phospholipase
chr7_+_6754109 0.16 ENST00000403107.5
ENST00000404077.5
ENST00000435395.5
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2
chr3_+_148739798 0.16 ENST00000402260.2
AGTR1
angiotensin II receptor type 1
chr19_+_44072142 0.15 ENST00000421176.4
ZNF284
zinc finger protein 284
chr6_-_62286161 0.15 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr6_+_116461364 0.13 ENST00000368606.7
ENST00000368605.3
CALHM6
calcium homeostasis modulator family member 6
chrX_+_111876177 0.12 ENST00000635763.2
TRPC5OS
TRPC5 opposite strand
chr2_-_75199511 0.12 ENST00000305249.10
TACR1
tachykinin receptor 1
chr17_+_76079182 0.12 ENST00000334586.10
ZACN
zinc activated ion channel
chr10_+_68106109 0.12 ENST00000540630.5
ENST00000354393.6
MYPN
myopalladin
chr16_+_2205708 0.09 ENST00000397124.5
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog
chr21_-_44928711 0.08 ENST00000517563.5
ITGB2
integrin subunit beta 2
chr2_-_31414694 0.08 ENST00000379416.4
XDH
xanthine dehydrogenase
chr3_+_9902808 0.07 ENST00000383814.8
ENST00000454190.6
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr1_+_18631513 0.07 ENST00000400661.3
PAX7
paired box 7
chr6_-_29368865 0.06 ENST00000641768.1
OR5V1
olfactory receptor family 5 subfamily V member 1
chr11_-_86068929 0.06 ENST00000630913.2
PICALM
phosphatidylinositol binding clathrin assembly protein
chr3_+_9902619 0.05 ENST00000421412.5
IL17RE
interleukin 17 receptor E
chr14_-_21023318 0.05 ENST00000298684.9
ENST00000557169.5
ENST00000553563.5
NDRG2
NDRG family member 2
chr11_-_74009077 0.05 ENST00000314032.9
ENST00000426995.2
UCP3
uncoupling protein 3
chr17_-_62065248 0.05 ENST00000397786.7
MED13
mediator complex subunit 13
chr2_-_162152239 0.05 ENST00000418842.7
GCG
glucagon
chr7_-_151187212 0.05 ENST00000420175.3
ENST00000275838.5
ASB10
ankyrin repeat and SOCS box containing 10
chr5_+_80319997 0.04 ENST00000296739.6
SPZ1
spermatogenic leucine zipper 1
chr6_+_46693835 0.04 ENST00000450697.1
TDRD6
tudor domain containing 6
chr1_+_166989254 0.03 ENST00000367872.9
ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chr10_-_96271508 0.02 ENST00000427367.6
ENST00000413476.6
ENST00000371176.6
BLNK
B cell linker
chrX_-_50200988 0.02 ENST00000358526.7
AKAP4
A-kinase anchoring protein 4
chr1_+_166989089 0.01 ENST00000367870.6
MAEL
maelstrom spermatogenic transposon silencer
chr12_-_108632073 0.01 ENST00000228463.6
SELPLG
selectin P ligand
chr8_-_100722731 0.01 ENST00000521865.6
ENST00000520804.2
ENST00000522720.2
ENST00000521067.1
PABPC1
poly(A) binding protein cytoplasmic 1
chrX_-_50200358 0.01 ENST00000437370.2
ENST00000376064.7
ENST00000448865.5
AKAP4
A-kinase anchoring protein 4
chr1_-_205994439 0.01 ENST00000617991.4
RAB7B
RAB7B, member RAS oncogene family
chr10_-_96271553 0.01 ENST00000224337.10
BLNK
B cell linker
chr6_-_149746497 0.00 ENST00000367404.8
ENST00000340413.7
ENST00000543637.1
NUP43
nucleoporin 43

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0042495 central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.3 2.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.3 3.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.7 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.4 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.2 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.9 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.6 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.5 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.3 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.1 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
0.0 0.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.4 GO:0097242 beta-amyloid clearance(GO:0097242)
0.0 0.3 GO:0042448 progesterone metabolic process(GO:0042448)
0.0 0.1 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.3 0.9 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.7 GO:0090543 Flemming body(GO:0090543)
0.0 0.8 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 2.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0030849 autosome(GO:0030849)
0.0 0.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 1.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.7 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 3.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS