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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for DUXA
Z-value: 0.89
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Transcription factors associated with DUXA
Network of associatons between targets according to the STRING database.
First level regulatory network of DUXA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_227813834 Show fit | 3.84 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
|
| chr21_+_42199686 Show fit | 2.37 |
ENST00000398457.6
|
ATP binding cassette subfamily G member 1 |
|
| chr12_-_48865863 Show fit | 1.92 |
ENST00000309739.6
|
Rho family GTPase 1 |
|
| chr1_+_12857086 Show fit | 1.76 |
ENST00000240189.2
|
PRAME family member 2 |
|
| chr2_+_201129318 Show fit | 1.51 |
ENST00000417748.1
|
CASP8 and FADD like apoptosis regulator |
|
| chr2_-_224947030 Show fit | 1.35 |
ENST00000409592.7
|
dedicator of cytokinesis 10 |
|
| chr1_+_12773738 Show fit | 1.21 |
ENST00000357726.5
|
PRAME family member 12 |
|
| chr11_-_4288083 Show fit | 1.16 |
ENST00000638166.1
|
SSU72 pseudogene 4 |
|
| chr2_+_201129483 Show fit | 1.14 |
ENST00000440180.5
|
CASP8 and FADD like apoptosis regulator |
|
| chr1_+_12791397 Show fit | 1.13 |
ENST00000332296.7
|
PRAME family member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.3 | 3.4 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.8 | 2.4 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.1 | 1.9 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.1 | 1.7 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.2 | 1.5 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.5 | 1.4 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.1 | 1.3 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 1.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.4 | 1.1 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 2.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 1.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 1.0 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.7 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.7 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 0.6 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.1 | 0.6 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 0.6 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 1.3 | 3.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 3.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.6 | 2.4 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 2.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 1.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 1.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 1.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.2 | 1.0 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.2 | 1.0 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 2.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.5 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.3 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 2.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.5 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 1.2 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.1 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.6 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |