ISMARA results: E2F6

Project

Inflammatory response time course, HUVEC (Wada, 2009)

Navigation

Downloads

Results for E2F6

Z-value: 2.26

Motif logo

Transcription factors associated with E2F6

Gene Symbol	Gene ID	Gene Info
E2F6 Ensembl NCBI GeneCards UniProt	ENSG00000169016.17	E2F6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F6	hg38_v1_chr2_-_11466156_11466177	-0.33	1.0e-01	Click!

Activity profile of E2F6 motif

Sorted Z-values of E2F6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr3_+_37861926 Show fit	12.40	ENST00000443503.6	CTDSPL Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like
chr3_+_37861849 Show fit	11.80	ENST00000273179.10	CTDSPL Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like
chr3_+_39809602 Show fit	11.59	ENST00000302541.11 ENST00000396217.7	MYRIP Ensembl NCBI GeneCards UniProt Show fit	myosin VIIA and Rab interacting protein
chr4_+_155667198 Show fit	11.51	ENST00000296518.11	GUCY1A1 Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155666963 Show fit	11.18	ENST00000455639.6	GUCY1A1 Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155667096 Show fit	11.13	ENST00000393832.7	GUCY1A1 Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 1 soluble subunit alpha 1
chr1_+_210232776 Show fit	9.93	ENST00000367012.4	SERTAD4 Ensembl NCBI GeneCards UniProt Show fit	SERTA domain containing 4
chr4_+_155666827 Show fit	9.81	ENST00000511507.5 ENST00000506455.6	GUCY1A1 Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 1 soluble subunit alpha 1
chr9_-_14322320 Show fit	8.65	ENST00000606230.2	NFIB Ensembl NCBI GeneCards UniProt Show fit	nuclear factor I B
chr1_+_87331668 Show fit	8.47	ENST00000370542.1	LMO4 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.2	35.0	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.2	17.2	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.5	16.6	GO:0010669	epithelial structure maintenance(GO:0010669)
0.5	16.5	GO:0014850	response to muscle activity(GO:0014850)
3.1	12.5	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.2	12.0	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
3.8	11.3	GO:0060995	cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
2.3	11.3	GO:0093001	glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
1.1	9.5	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.8	9.5	GO:0042659	regulation of cell fate specification(GO:0042659)

Showing 1 to 10 of 625 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	52.2	GO:0005667	transcription factor complex(GO:0005667)
1.3	34.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.1	21.2	GO:0005814	centriole(GO:0005814)
1.1	12.5	GO:0005955	calcineurin complex(GO:0005955)
0.3	11.8	GO:0005640	nuclear outer membrane(GO:0005640)
0.4	11.6	GO:0000145	exocyst(GO:0000145)
1.1	11.5	GO:0016589	NURF complex(GO:0016589)
1.7	10.4	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	9.9	GO:0035579	specific granule membrane(GO:0035579)
0.2	9.4	GO:0030173	integral component of Golgi membrane(GO:0030173)

Showing 1 to 10 of 221 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	30.9	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
0.2	22.9	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.9	15.8	GO:0008140	cAMP response element binding protein binding(GO:0008140)
1.2	15.7	GO:0030274	LIM domain binding(GO:0030274)
0.8	13.2	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.3	11.8	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
1.6	10.9	GO:0005134	interleukin-2 receptor binding(GO:0005134)
1.3	10.7	GO:0003872	6-phosphofructokinase activity(GO:0003872)
1.6	9.4	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.1	9.3	GO:0008094	DNA-dependent ATPase activity(GO:0008094)

Showing 1 to 10 of 374 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	36.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	27.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.5	25.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	15.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	15.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	14.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	11.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	10.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	9.6	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	8.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Showing 1 to 10 of 73 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	35.0	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.3	14.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.3	12.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.3	11.5	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.3	11.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	11.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	10.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.6	10.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.4	9.8	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.3	9.2	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation

Showing 1 to 10 of 111 entries

Results for E2F6

Z-value: 2.26

Motif logo

Transcription factors associated with E2F6

Activity-expression correlation:

Activity profile of E2F6 motif

Sorted Z-values of E2F6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: