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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for E2F7_E2F1
Z-value: 1.54
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg38_v1_chr12_-_77065526_77065586 | 0.55 | 4.3e-03 | Click! |
| E2F1 | hg38_v1_chr20_-_33686371_33686407 | 0.07 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.1 | 5.0 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.1 | 4.6 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) |
| 0.0 | 4.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 4.2 | GO:1904668 | positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 0.8 | 3.9 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 1.1 | 3.4 | GO:0008615 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819) |
| 0.1 | 3.0 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.9 | 2.8 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.2 | 2.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 3.9 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 3.9 | GO:0000779 | condensed chromosome, centromeric region(GO:0000779) |
| 0.3 | 3.6 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 3.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.4 | 3.4 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 3.4 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.4 | 3.1 | GO:0000796 | condensin complex(GO:0000796) |
| 0.2 | 2.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 2.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 5.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 4.6 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.4 | 4.1 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 4.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 3.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.8 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.7 | 2.7 | GO:0035501 | MH1 domain binding(GO:0035501) |
| 0.1 | 2.4 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 2.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 6.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 6.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 3.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 2.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 2.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 4.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 4.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 3.6 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 3.3 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 3.1 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.2 | 2.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.9 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 2.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |