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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for EBF1
Z-value: 1.66
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Transcription factors associated with EBF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EBF1 | hg38_v1_chr5_-_159099684_159099698, hg38_v1_chr5_-_159099745_159099789 | 0.29 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EBF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_31582415 Show fit | 12.86 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr1_-_184974477 Show fit | 7.59 |
ENST00000367511.4
|
niban apoptosis regulator 1 |
|
| chr19_+_4229502 Show fit | 6.20 |
ENST00000221847.6
|
Epstein-Barr virus induced 3 |
|
| chr8_+_23528947 Show fit | 5.04 |
ENST00000519973.6
|
solute carrier family 25 member 37 |
|
| chr12_-_48865863 Show fit | 4.82 |
ENST00000309739.6
|
Rho family GTPase 1 |
|
| chr4_+_73836667 Show fit | 4.72 |
ENST00000226317.10
|
C-X-C motif chemokine ligand 6 |
|
| chr6_-_159726871 Show fit | 4.67 |
ENST00000535561.5
|
superoxide dismutase 2 |
|
| chr15_+_67138001 Show fit | 4.63 |
ENST00000439724.7
|
SMAD family member 3 |
|
| chr2_+_149330506 Show fit | 4.48 |
ENST00000334166.9
|
LY6/PLAUR domain containing 6 |
|
| chr2_+_109129199 Show fit | 4.30 |
ENST00000309415.8
|
SH3 domain containing ring finger 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 12.9 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 12.3 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 1.6 | 9.7 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.3 | 9.6 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 3.0 | 9.1 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.3 | 7.2 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.4 | 6.4 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 1.4 | 5.6 | GO:0060611 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.5 | 5.4 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.4 | 5.2 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.1 | 9.7 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 9.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 5.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.9 | 5.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.2 | 5.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.3 | 5.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.2 | 5.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 4.9 | GO:0005605 | basal lamina(GO:0005605) |
| 0.6 | 4.5 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 18.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 10.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.6 | 9.7 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.2 | 9.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.6 | 9.1 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.4 | 8.4 | GO:0031701 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 8.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 7.6 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.5 | 7.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 9.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 8.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.3 | 8.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 8.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 8.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 7.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.2 | 7.8 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.2 | 7.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 6.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 12.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 10.0 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 8.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 6.7 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 6.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 5.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 5.1 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 5.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |