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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for EGR3_EGR2
Z-value: 1.48
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Transcription factors associated with EGR3_EGR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR2 | hg38_v1_chr10_-_62816341_62816388, hg38_v1_chr10_-_62816309_62816320 | -0.71 | 6.2e-05 | Click! |
| EGR3 | hg38_v1_chr8_-_22693469_22693487 | -0.68 | 2.0e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR3_EGR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_50742110 Show fit | 7.44 |
ENST00000566679.6
ENST00000564634.5 ENST00000398568.6 |
CYLD lysine 63 deubiquitinase |
|
| chr16_+_50742037 Show fit | 7.44 |
ENST00000569418.5
|
CYLD lysine 63 deubiquitinase |
|
| chr16_+_50742059 Show fit | 5.95 |
ENST00000311559.13
ENST00000564326.5 ENST00000566206.5 ENST00000427738.8 |
CYLD lysine 63 deubiquitinase |
|
| chr3_+_53161241 Show fit | 5.33 |
ENST00000477794.2
ENST00000650739.1 |
protein kinase C delta |
|
| chr6_-_142945028 Show fit | 4.92 |
ENST00000012134.7
|
HIVEP zinc finger 2 |
|
| chr6_-_142945160 Show fit | 4.85 |
ENST00000367603.8
|
HIVEP zinc finger 2 |
|
| chr5_+_132257670 Show fit | 4.77 |
ENST00000253754.8
ENST00000379018.7 |
PDZ and LIM domain 4 |
|
| chr9_-_93134234 Show fit | 4.64 |
ENST00000375446.5
|
ninjurin 1 |
|
| chr8_+_17497108 Show fit | 4.56 |
ENST00000470360.5
|
solute carrier family 7 member 2 |
|
| chr8_+_17497078 Show fit | 4.37 |
ENST00000494857.6
ENST00000522656.5 |
solute carrier family 7 member 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 20.8 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.7 | 9.6 | GO:0021840 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 3.0 | 9.1 | GO:2000754 | regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755) |
| 3.0 | 8.9 | GO:1903400 | L-arginine transmembrane transport(GO:1903400) |
| 0.0 | 8.4 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.1 | 7.0 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.1 | 6.7 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.4 | 6.6 | GO:0045656 | negative regulation of monocyte differentiation(GO:0045656) |
| 0.7 | 6.0 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.9 | 5.1 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 11.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 9.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 9.8 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.1 | 6.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.7 | 5.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 4.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 4.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.3 | 4.4 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 4.3 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 29.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 12.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.5 | 9.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 1.5 | 9.1 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 3.0 | 8.9 | GO:0005289 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.1 | 7.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 6.9 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 6.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.3 | 6.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.6 | 5.1 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 12.0 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.2 | 9.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 8.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 7.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 6.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 6.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 6.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 5.0 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 4.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 23.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.4 | 16.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 16.0 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.3 | 11.3 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 8.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 6.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 6.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 5.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 5.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 4.8 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |