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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ELF2_GABPA_ELF5
Z-value: 1.81
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Transcription factors associated with ELF2_GABPA_ELF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GABPA | hg38_v1_chr21_+_25734948_25734988 | -0.36 | 7.6e-02 | Click! |
| ELF5 | hg38_v1_chr11_-_34513750_34513771 | 0.33 | 1.1e-01 | Click! |
| ELF2 | hg38_v1_chr4_-_139177185_139177227 | -0.31 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.0 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 16.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.4 | 12.6 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.3 | 11.5 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.6 | 10.8 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.6 | 10.5 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) |
| 0.8 | 9.7 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.1 | 9.6 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.3 | 8.6 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.1 | 8.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 24.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 22.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 19.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 13.1 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 9.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.2 | 9.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 7.5 | GO:0030684 | preribosome(GO:0030684) |
| 0.5 | 7.1 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.4 | 7.0 | GO:0061700 | GATOR2 complex(GO:0061700) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 58.0 | GO:0003677 | DNA binding(GO:0003677) |
| 2.4 | 36.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.5 | 15.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 13.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 12.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.7 | 11.9 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.0 | 9.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 8.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 8.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 8.0 | GO:0043531 | ADP binding(GO:0043531) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 6.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 5.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 4.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 4.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.3 | 4.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 4.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 4.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 61.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 38.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 14.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.4 | 13.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 12.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 12.0 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.3 | 9.8 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 6.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 5.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 5.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |