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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ELK4_ETV5_ELK1_ELK3_ELF4
Z-value: 1.56
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Transcription factors associated with ELK4_ETV5_ELK1_ELK3_ELF4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000158711.14 | ELK4 | |
| ENSG00000244405.8 | ETV5 | |
| ENSG00000126767.18 | ELK1 | |
| ENSG00000111145.8 | ELK3 | |
| ENSG00000102034.17 | ELF4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF4 | hg38_v1_chrX_-_130110479_130110514 | -0.40 | 5.0e-02 | Click! |
| ETV5 | hg38_v1_chr3_-_186109067_186109117 | 0.36 | 7.9e-02 | Click! |
| ELK4 | hg38_v1_chr1_-_205631962_205632030 | 0.26 | 2.1e-01 | Click! |
| ELK1 | hg38_v1_chrX_-_47650488_47650591 | -0.26 | 2.1e-01 | Click! |
| ELK3 | hg38_v1_chr12_+_96194365_96194407 | 0.17 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELK4_ETV5_ELK1_ELK3_ELF4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.4 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 0.5 | 10.7 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.1 | 9.6 | GO:0033108 | mitochondrial respiratory chain complex assembly(GO:0033108) |
| 0.1 | 9.3 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.2 | 7.6 | GO:0007099 | centriole replication(GO:0007099) |
| 2.5 | 7.5 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.4 | 7.2 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.2 | 7.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.3 | 6.4 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.2 | 6.3 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 45.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 10.8 | GO:0005814 | centriole(GO:0005814) |
| 0.6 | 9.2 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.7 | 8.4 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 7.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 7.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 7.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.2 | 6.8 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.2 | 6.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 6.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 46.2 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 23.9 | GO:0003677 | DNA binding(GO:0003677) |
| 0.1 | 18.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 10.2 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.1 | 9.7 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.4 | 7.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.2 | 6.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 6.4 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.6 | 6.3 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.1 | 6.3 | GO:0004527 | exonuclease activity(GO:0004527) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 4.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 3.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 3.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 1.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 49.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 12.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 11.0 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 7.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 7.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 6.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 6.2 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.2 | 6.2 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.2 | 5.3 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 5.3 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |