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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for EMX2
Z-value: 0.65
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Transcription factors associated with EMX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EMX2 | hg38_v1_chr10_+_117543567_117543658, hg38_v1_chr10_+_117542416_117542445, hg38_v1_chr10_+_117542721_117542754 | 0.35 | 8.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EMX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 2.7 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 1.8 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.1 | 1.5 | GO:0061141 | lung ciliated cell differentiation(GO:0061141) |
| 0.0 | 1.4 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 1.4 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 1.3 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.1 | 1.2 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.1 | 1.2 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 1.1 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 3.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 2.0 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.0 | 1.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 1.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 1.0 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 1.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 0.7 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.1 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 2.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.3 | 1.9 | GO:0042806 | fucose binding(GO:0042806) |
| 0.1 | 1.9 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 1.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 1.6 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 1.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 1.2 | GO:0016402 | pristanoyl-CoA oxidase activity(GO:0016402) |
| 0.1 | 1.2 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.1 | 1.0 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 1.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 2.0 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 1.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.1 | 1.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.2 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 1.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |