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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for EMX2

Z-value: 0.65

Motif logo

Transcription factors associated with EMX2

Gene Symbol Gene ID Gene Info
ENSG00000170370.12 EMX2

Activity-expression correlation:

Activity profile of EMX2 motif

Sorted Z-values of EMX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_84181630 3.02 ENST00000610457.1
protein kinase cAMP-activated catalytic subunit beta
chr4_+_41538143 2.65 ENST00000503057.6
ENST00000511496.5
LIM and calponin homology domains 1
chr1_+_84144260 2.07 ENST00000370685.7
protein kinase cAMP-activated catalytic subunit beta
chr4_-_100517991 1.95 ENST00000511970.5
ENST00000502569.1
ENST00000305864.7
ENST00000296420.9
endomucin
chr7_+_80133830 1.95 ENST00000648098.1
ENST00000648476.1
ENST00000648412.1
ENST00000648953.1
ENST00000648306.1
ENST00000648832.1
ENST00000648877.1
ENST00000442586.2
ENST00000649487.1
ENST00000649267.1
G protein subunit alpha i1
chr19_+_14583076 1.90 ENST00000547437.5
ENST00000417570.6
C-type lectin domain containing 17A
chr2_-_98663464 1.87 ENST00000414521.6
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
chr6_-_75363003 1.64 ENST00000370020.1
filamin A interacting protein 1
chr4_-_185956652 1.45 ENST00000355634.9
sorbin and SH3 domain containing 2
chr10_-_91633057 1.33 ENST00000238994.6
protein phosphatase 1 regulatory subunit 3C
chr4_-_88284747 1.29 ENST00000514204.1
protein phosphatase, Mg2+/Mn2+ dependent 1K
chr9_-_41908681 1.27 ENST00000476961.5
contactin associated protein family member 3B
chr4_-_185956348 1.27 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
sorbin and SH3 domain containing 2
chr1_+_78004930 1.26 ENST00000370763.6
DnaJ heat shock protein family (Hsp40) member B4
chr11_-_63608542 1.25 ENST00000540943.1
phospholipase A and acyltransferase 3
chr17_-_69141878 1.18 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr9_-_14314132 1.15 ENST00000380953.6
nuclear factor I B
chr18_-_55423757 1.03 ENST00000675707.1
transcription factor 4
chr9_+_128566741 1.03 ENST00000630866.1
spectrin alpha, non-erythrocytic 1
chr14_+_24120956 0.95 ENST00000558325.2
novel protein
chr12_-_24902243 0.92 ENST00000538118.5
branched chain amino acid transaminase 1
chr5_-_111976925 0.90 ENST00000395634.7
neuronal regeneration related protein
chr1_+_77918128 0.89 ENST00000342754.5
nexilin F-actin binding protein
chr6_-_110179995 0.87 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASP family member 1
chr6_+_135851681 0.87 ENST00000308191.11
phosphodiesterase 7B
chr5_-_56116946 0.86 ENST00000434982.2
ankyrin repeat domain 55
chr8_+_97887903 0.83 ENST00000520016.5
matrilin 2
chr4_-_137532452 0.77 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr11_-_125111708 0.76 ENST00000531909.5
ENST00000529530.1
transmembrane protein 218
chr6_+_28124596 0.76 ENST00000340487.5
zinc finger and SCAN domain containing 16
chr3_-_122793772 0.74 ENST00000306103.3
HSPB1 associated protein 1
chr9_+_72577939 0.73 ENST00000645773.1
transmembrane channel like 1
chr3_-_142029108 0.72 ENST00000497579.5
transcription factor Dp-2
chr6_-_53510445 0.70 ENST00000509541.5
glutamate-cysteine ligase catalytic subunit
chr1_-_160954801 0.69 ENST00000368029.4
intelectin 2
chr12_+_59689337 0.69 ENST00000261187.8
solute carrier family 16 member 7
chr9_-_21202205 0.66 ENST00000239347.3
interferon alpha 7
chr5_-_140633690 0.66 ENST00000512545.1
ENST00000401743.6
CD14 molecule
chr12_-_57826295 0.66 ENST00000549039.5
CTD small phosphatase 2
chr5_-_9630351 0.66 ENST00000382492.4
taste 2 receptor member 1
chr3_-_142000353 0.64 ENST00000499676.5
transcription factor Dp-2
chr17_-_445939 0.64 ENST00000329099.4
refilin B
chr1_-_44986568 0.63 ENST00000372183.7
ENST00000360403.7
ENST00000620860.4
eukaryotic translation initiation factor 2B subunit gamma
chr3_-_58537283 0.62 ENST00000459701.6
acyl-CoA oxidase 2
chr1_+_28438104 0.61 ENST00000633167.1
ENST00000373836.4
phosphatase and actin regulator 4
chr3_-_58537181 0.61 ENST00000302819.10
acyl-CoA oxidase 2
chr12_-_122716790 0.61 ENST00000528880.3
hydroxycarboxylic acid receptor 3
chr3_-_185821092 0.60 ENST00000421047.3
insulin like growth factor 2 mRNA binding protein 2
chr5_+_90640718 0.60 ENST00000640403.1
adhesion G protein-coupled receptor V1
chr6_+_29111560 0.60 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr3_+_132597260 0.59 ENST00000249887.3
atypical chemokine receptor 4
chr12_-_68302872 0.59 ENST00000539972.5
Mdm1 nuclear protein
chr3_+_113897470 0.57 ENST00000440446.2
ENST00000488680.1
GRAM domain containing 1C
chr17_+_68525795 0.57 ENST00000592800.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr4_-_25863537 0.57 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr21_-_30497160 0.55 ENST00000334058.3
keratin associated protein 19-4
chr9_-_76906041 0.55 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
prune homolog 2 with BCH domain
chr6_+_72216442 0.55 ENST00000425662.6
ENST00000453976.6
regulating synaptic membrane exocytosis 1
chr9_-_5833014 0.55 ENST00000339450.10
endoplasmic reticulum metallopeptidase 1
chr19_+_49513353 0.53 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr17_-_55511434 0.52 ENST00000636752.1
small integral membrane protein 36
chr7_+_116222804 0.48 ENST00000393481.6
testin LIM domain protein
chr12_+_125065427 0.47 ENST00000316519.11
acetoacetyl-CoA synthetase
chr18_+_32190015 0.46 ENST00000581447.1
meprin A subunit beta
chr4_-_109801978 0.46 ENST00000510800.1
ENST00000512148.5
ENST00000394634.7
ENST00000394635.8
ENST00000645635.1
complement factor I
novel protein
chr19_-_51417700 0.45 ENST00000529627.1
ENST00000439889.6
sialic acid binding Ig like lectin 10
chr1_+_117001744 0.45 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101 molecule
chr20_-_31390580 0.44 ENST00000339144.3
ENST00000376321.4
defensin beta 119
chr18_+_32190033 0.44 ENST00000269202.11
meprin A subunit beta
chr5_+_140875299 0.44 ENST00000613593.1
ENST00000398631.3
protocadherin alpha 12
chr1_+_162790702 0.44 ENST00000254521.8
ENST00000367915.1
hydroxysteroid 17-beta dehydrogenase 7
chrX_+_77910656 0.44 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr8_+_69492793 0.43 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
sulfatase 1
chr11_-_119196769 0.43 ENST00000415318.2
coiled-coil domain containing 153
chr19_-_54941610 0.42 ENST00000328092.9
ENST00000590030.5
NLR family pyrin domain containing 7
chr3_+_111674654 0.42 ENST00000636933.1
ENST00000393934.7
ENST00000477665.2
phosphatidylinositol specific phospholipase C X domain containing 2
chr19_-_4558417 0.41 ENST00000586965.1
semaphorin 6B
chr16_+_56961942 0.41 ENST00000200676.8
ENST00000566128.1
cholesteryl ester transfer protein
chr12_+_29149238 0.40 ENST00000536681.8
fatty acyl-CoA reductase 2
chr22_-_32464440 0.39 ENST00000397450.2
ENST00000397452.5
ENST00000300399.8
BPI fold containing family C
chr1_+_92168915 0.39 ENST00000637221.2
BTB domain containing 8
chr11_+_74592567 0.38 ENST00000263681.7
ENST00000527458.5
ENST00000532497.5
ENST00000530511.5
DNA polymerase delta 3, accessory subunit
chr11_+_119149029 0.37 ENST00000619701.5
ATP binding cassette subfamily G member 4
chr11_-_60183191 0.37 ENST00000412309.6
membrane spanning 4-domains A6A
chr1_+_15341744 0.36 ENST00000444385.5
forkhead associated phosphopeptide binding domain 1
chr16_+_18983927 0.36 ENST00000569532.5
ENST00000304381.10
transmembrane channel like 7
chr6_+_72212802 0.35 ENST00000401910.7
regulating synaptic membrane exocytosis 1
chr7_+_107583919 0.35 ENST00000491150.5
B cell receptor associated protein 29
chr3_+_159839847 0.35 ENST00000445224.6
schwannomin interacting protein 1
chr5_+_42548043 0.34 ENST00000618088.4
ENST00000612382.4
growth hormone receptor
chr12_+_101594849 0.34 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
myosin binding protein C1
chr1_+_207325629 0.34 ENST00000618707.2
CD55 molecule (Cromer blood group)
chr19_-_58353482 0.34 ENST00000263100.8
alpha-1-B glycoprotein
chr16_+_86566821 0.33 ENST00000649859.1
forkhead box C2
chr6_+_27865308 0.33 ENST00000613174.2
H2A clustered histone 16
chr5_+_148394712 0.33 ENST00000513826.1
F-box protein 38
chr15_-_44711306 0.32 ENST00000682850.1
PAT1 homolog 2
chr5_-_88823763 0.32 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
myocyte enhancer factor 2C
chr4_-_99435396 0.31 ENST00000209665.8
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chrX_+_47585212 0.31 ENST00000445623.1
TIMP metallopeptidase inhibitor 1
chr17_-_76141240 0.31 ENST00000322957.7
forkhead box J1
chr2_-_110212519 0.31 ENST00000611969.5
mitoregulin
chr5_-_112419251 0.30 ENST00000261486.6
erythrocyte membrane protein band 4.1 like 4A
chr6_+_72212887 0.30 ENST00000523963.5
regulating synaptic membrane exocytosis 1
chr1_-_219613069 0.30 ENST00000367211.6
ENST00000651890.1
zinc finger CCCH-type containing 11B
chr7_+_1688119 0.30 ENST00000424383.4
extracellular leucine rich repeat and fibronectin type III domain containing 1
chr1_-_17045219 0.30 ENST00000491274.5
succinate dehydrogenase complex iron sulfur subunit B
chr19_-_51417791 0.30 ENST00000353836.9
sialic acid binding Ig like lectin 10
chr8_-_132675567 0.30 ENST00000519595.5
leucine rich repeat containing 6
chr6_+_42050876 0.29 ENST00000465926.5
ENST00000482432.1
TATA-box binding protein associated factor 8
chr12_-_10826358 0.29 ENST00000240619.2
taste 2 receptor member 10
chr20_+_4686448 0.29 ENST00000379440.9
ENST00000424424.2
ENST00000457586.2
prion protein
chr3_+_98147479 0.29 ENST00000641380.1
olfactory receptor family 5 subfamily H member 14
chr15_-_19988117 0.29 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr13_+_108269629 0.27 ENST00000430559.5
ENST00000375887.9
TNF superfamily member 13b
chrX_+_55717733 0.26 ENST00000414239.5
ENST00000374941.9
Ras related GTP binding B
chrX_+_55717796 0.26 ENST00000262850.7
Ras related GTP binding B
chr8_+_12104389 0.26 ENST00000400085.7
zinc finger protein 705D
chr8_+_26293112 0.26 ENST00000523925.5
ENST00000315985.7
protein phosphatase 2 regulatory subunit Balpha
chr14_+_101809795 0.26 ENST00000350249.7
ENST00000557621.5
ENST00000556946.1
protein phosphatase 2 regulatory subunit B'gamma
chr12_-_91180365 0.26 ENST00000547937.5
decorin
chr5_+_119476530 0.26 ENST00000645099.1
ENST00000513628.5
hydroxysteroid 17-beta dehydrogenase 4
chr2_+_43774033 0.26 ENST00000260605.12
ENST00000406852.7
ENST00000398823.6
ENST00000605786.5
dynein cytoplasmic 2 light intermediate chain 1
chr12_-_21910853 0.25 ENST00000544039.5
ATP binding cassette subfamily C member 9
chr6_+_26251607 0.25 ENST00000619466.2
H2B clustered histone 9
chr20_+_5750437 0.25 ENST00000445603.1
ENST00000442185.1
shieldin complex subunit 1
chr1_-_248277976 0.25 ENST00000641220.1
olfactory receptor family 2 subfamily T member 33
chr11_-_125111579 0.25 ENST00000532156.5
ENST00000532407.5
ENST00000279968.8
ENST00000527766.5
ENST00000529583.5
ENST00000524373.5
ENST00000527271.5
ENST00000526175.5
ENST00000529609.5
ENST00000682305.1
ENST00000533273.1
transmembrane protein 218
chr18_+_22933321 0.25 ENST00000327155.10
RB binding protein 8, endonuclease
chr12_-_122703346 0.25 ENST00000328880.6
hydroxycarboxylic acid receptor 2
chr16_+_28637654 0.24 ENST00000529716.5
nuclear pore complex interacting protein family member B8
chr20_+_5750381 0.24 ENST00000378979.8
ENST00000303142.11
shieldin complex subunit 1
chr6_+_116100813 0.24 ENST00000419791.3
ENST00000319550.9
5'-nucleotidase domain containing 1
chr13_+_48256214 0.24 ENST00000650237.1
integral membrane protein 2B
chr3_+_148791058 0.24 ENST00000491148.5
carboxypeptidase B1
chr12_+_74537787 0.24 ENST00000519948.4
ataxin 7 like 3B
chr10_+_13610047 0.24 ENST00000601460.5
novel protein
chr3_+_159069252 0.23 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1 readthrough
chr9_+_122519141 0.23 ENST00000340750.1
olfactory receptor family 1 subfamily J member 4
chr9_+_72577369 0.23 ENST00000651183.1
transmembrane channel like 1
chr17_-_41168219 0.23 ENST00000391356.4
keratin associated protein 4-3
chr4_-_99435336 0.23 ENST00000437033.7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr15_+_58410543 0.23 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr7_-_150302980 0.23 ENST00000252071.8
actin related protein 3C
chr5_+_55160161 0.23 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
glutathione peroxidase 8 (putative)
chr8_+_66775178 0.22 ENST00000396596.2
ENST00000521960.5
ENST00000522398.5
ENST00000522629.5
ENST00000520976.5
serum/glucocorticoid regulated kinase family member 3
chr4_-_67545464 0.22 ENST00000273853.11
centromere protein C
chr12_-_53321544 0.22 ENST00000394384.7
ENST00000209873.9
aladin WD repeat nucleoporin
chr4_-_99219230 0.22 ENST00000394897.5
ENST00000508558.1
ENST00000394899.6
alcohol dehydrogenase 6 (class V)
chr16_+_15395745 0.21 ENST00000287594.7
ENST00000396385.4
ENST00000568766.1
MPV17 mitochondrial inner membrane protein like
novel protein
chr1_-_60073750 0.21 ENST00000371201.3
chromosome 1 open reading frame 87
chr1_-_36149464 0.20 ENST00000373166.8
ENST00000373159.1
ENST00000373162.5
ENST00000616074.4
ENST00000616395.4
trafficking protein particle complex 3
chr5_-_78985951 0.20 ENST00000396151.7
arylsulfatase B
chr12_+_18242955 0.20 ENST00000676171.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr3_+_131026844 0.20 ENST00000510769.5
ENST00000383366.9
ENST00000510688.5
ENST00000511262.5
NIMA related kinase 11
chr3_+_119579577 0.20 ENST00000478927.5
ADP-ribosylarginine hydrolase
chrX_+_136648214 0.20 ENST00000370628.2
CD40 ligand
chr11_+_66509079 0.20 ENST00000419755.3
novel protein
chr9_+_72577788 0.20 ENST00000645208.2
transmembrane channel like 1
chr2_+_48568981 0.20 ENST00000394754.5
STON1-GTF2A1L readthrough
chr6_+_28349907 0.20 ENST00000252211.7
ENST00000341464.9
ENST00000377255.3
zinc finger with KRAB and SCAN domains 3
chr16_+_69565958 0.20 ENST00000349945.7
ENST00000354436.6
nuclear factor of activated T cells 5
chr17_+_38003976 0.19 ENST00000616101.4
TBC1 domain family member 3D
chr17_-_37989048 0.19 ENST00000617678.2
ENST00000612727.5
TBC1 domain family member 3L
chr17_+_38127951 0.19 ENST00000621587.2
TBC1 domain family member 3E
chr11_-_60183011 0.19 ENST00000533023.5
ENST00000420732.6
ENST00000528851.6
membrane spanning 4-domains A6A
chr6_+_110180418 0.19 ENST00000368930.5
ENST00000307731.2
cell division cycle 40
chr8_+_109540602 0.19 ENST00000530629.5
ENST00000620557.4
estrogen receptor binding site associated antigen 9
chr11_+_7088991 0.18 ENST00000306904.7
RBMX like 2
chr21_+_30396030 0.18 ENST00000355459.4
keratin associated protein 13-1
chr14_-_89954518 0.18 ENST00000556005.1
ENST00000555872.5
EF-hand calcium binding domain 11
chr16_-_28363508 0.17 ENST00000532254.1
nuclear pore complex interacting protein family member B6
chr15_-_99249523 0.17 ENST00000560235.1
ENST00000394132.7
ENST00000560860.5
ENST00000558078.5
ENST00000560772.5
tetratricopeptide repeat domain 23
chr9_-_96778053 0.17 ENST00000375231.5
ENST00000223428.9
zinc finger protein 510
chr6_-_29375291 0.17 ENST00000396806.3
olfactory receptor family 12 subfamily D member 3
chr17_-_44023106 0.17 ENST00000585950.5
ENST00000592127.5
ENST00000589334.5
transmembrane protein 101
chr1_-_34985288 0.17 ENST00000417456.1
ENST00000373337.3
novel protein
transmembrane protein 35B
chr9_-_21217311 0.16 ENST00000380216.1
interferon alpha 16
chr20_-_35411963 0.16 ENST00000349714.9
ENST00000438533.5
ENST00000359226.6
ENST00000374384.6
ENST00000374385.10
ENST00000424405.5
ENST00000397554.5
ENST00000374380.6
ubiquinol-cytochrome c reductase complex assembly factor 1
chr3_-_151329539 0.16 ENST00000325602.6
purinergic receptor P2Y13
chr10_+_13161543 0.16 ENST00000378714.8
ENST00000479669.5
ENST00000484800.6
minichromosome maintenance 10 replication initiation factor
chr2_-_112433519 0.16 ENST00000496537.1
ENST00000330575.9
ENST00000302558.8
RANBP2 like and GRIP domain containing 8
chr6_-_26234978 0.16 ENST00000244534.7
H1.3 linker histone, cluster member
chr14_+_24070837 0.15 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
copine 6
chr15_-_65133780 0.15 ENST00000204549.9
programmed cell death 7
chr2_+_206159884 0.15 ENST00000392222.7
eukaryotic translation elongation factor 1 beta 2
chrX_+_136648138 0.15 ENST00000370629.7
CD40 ligand
chr1_+_81306096 0.15 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
adhesion G protein-coupled receptor L2
chr10_-_69409275 0.15 ENST00000373307.5
tachykinin receptor 2
chr16_+_72054477 0.15 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
haptoglobin
chr1_-_53940100 0.15 ENST00000371376.1
heat shock protein family B (small) member 11
chr8_-_53842899 0.15 ENST00000524234.1
ENST00000521275.5
ENST00000396774.6
ATPase H+ transporting V1 subunit H
chr6_-_73521783 0.15 ENST00000331523.7
ENST00000356303.7
eukaryotic translation elongation factor 1 alpha 1
chr2_-_55010348 0.14 ENST00000394609.6
reticulon 4
chr1_-_36149450 0.14 ENST00000373163.5
trafficking protein particle complex 3
chr7_+_90709530 0.14 ENST00000406263.5
cyclin dependent kinase 14
chr4_-_88697810 0.14 ENST00000323061.7
nucleosome assembly protein 1 like 5
chr6_-_52840843 0.14 ENST00000370989.6
glutathione S-transferase alpha 5
chr5_-_177780633 0.14 ENST00000513554.5
ENST00000440605.7
family with sequence similarity 153 member A
chr11_+_122838492 0.14 ENST00000227348.9
cytotoxic and regulatory T cell molecule

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.1 GO:0097338 response to clozapine(GO:0097338)
0.2 0.6 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.2 0.6 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 0.9 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 0.7 GO:0097069 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.1 0.4 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.1 0.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.4 GO:0071284 copper ion export(GO:0060003) cellular response to lead ion(GO:0071284)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.7 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 1.8 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 1.2 GO:0060005 vestibular reflex(GO:0060005)
0.1 1.5 GO:0061141 lung ciliated cell differentiation(GO:0061141)
0.1 0.3 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.1 0.9 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.7 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.3 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.1 0.3 GO:1990535 neuron projection maintenance(GO:1990535)
0.1 0.6 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.1 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.1 2.7 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.2 GO:0061580 colon epithelial cell migration(GO:0061580)
0.1 0.3 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.1 0.5 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.1 0.4 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 1.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.3 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1 0.5 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.3 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 1.1 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.0 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.6 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 1.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045) negative regulation of trophoblast cell migration(GO:1901164)
0.0 0.1 GO:0035106 operant conditioning(GO:0035106)
0.0 0.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.4 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.3 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.1 GO:0060467 negative regulation of fertilization(GO:0060467)
0.0 0.1 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 1.1 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.1 GO:0014056 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056)
0.0 0.2 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.4 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 1.0 GO:0051693 actin filament capping(GO:0051693)
0.0 1.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.8 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 0.2 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.0 0.3 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.2 GO:0042832 carbohydrate mediated signaling(GO:0009756) defense response to protozoan(GO:0042832)
0.0 0.1 GO:2000617 positive regulation of histone H3-K9 acetylation(GO:2000617)
0.0 0.1 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.7 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.5 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.1 1.0 GO:0008091 spectrin(GO:0008091)
0.0 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 2.0 GO:0099738 cell cortex region(GO:0099738)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) nuclear pericentric heterochromatin(GO:0031618)
0.0 3.9 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 1.9 GO:0042806 fucose binding(GO:0042806)
0.2 1.2 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 1.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 0.9 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.7 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.6 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 0.4 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.4 GO:0004008 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.1 0.4 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.4 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 2.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.1 1.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.3 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1 0.7 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.3 GO:1903135 cupric ion binding(GO:1903135)
0.1 0.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.1 GO:0016497 substance K receptor activity(GO:0016497)
0.0 1.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.5 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:1902271 D3 vitamins binding(GO:1902271)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.6 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.0 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID IL3 PATHWAY IL3-mediated signaling events
0.1 1.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 5.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.5 PID E2F PATHWAY E2F transcription factor network
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 5.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 1.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis