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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ESRRA_ESR2
Z-value: 1.55
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR2 | hg38_v1_chr14_-_64338096_64338124 | 0.72 | 4.2e-05 | Click! |
| ESRRA | hg38_v1_chr11_+_64306227_64306446 | 0.37 | 7.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_10086787 Show fit | 5.65 |
ENST00000590378.5
ENST00000397881.7 |
shiftless antiviral inhibitor of ribosomal frameshifting |
|
| chr9_-_120914549 Show fit | 5.14 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr2_+_227813834 Show fit | 5.12 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
|
| chr12_+_112978386 Show fit | 4.78 |
ENST00000342315.8
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr14_+_24161257 Show fit | 4.64 |
ENST00000396864.8
ENST00000557894.5 ENST00000559284.5 ENST00000560275.5 |
interferon regulatory factor 9 |
|
| chr1_-_205321737 Show fit | 4.62 |
ENST00000367157.6
|
NUAK family kinase 2 |
|
| chr4_-_687325 Show fit | 4.57 |
ENST00000503156.5
|
solute carrier family 49 member 3 |
|
| chr10_-_48604952 Show fit | 4.51 |
ENST00000417912.6
|
Rho GTPase activating protein 22 |
|
| chr11_-_60952559 Show fit | 4.47 |
ENST00000538739.2
|
solute carrier family 15 member 3 |
|
| chr14_+_103121457 Show fit | 4.39 |
ENST00000333007.8
|
TNF alpha induced protein 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.1 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.1 | 13.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 11.8 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 2.3 | 11.6 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 1.0 | 11.6 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.4 | 11.6 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 1.7 | 10.4 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 9.2 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.5 | 7.0 | GO:0046449 | creatinine metabolic process(GO:0046449) |
| 0.4 | 6.7 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.2 | 10.4 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 8.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 1.0 | 7.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.4 | 7.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.4 | 6.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.8 | 6.2 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.1 | 6.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 5.8 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 5.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.6 | GO:0005125 | cytokine activity(GO:0005125) |
| 1.2 | 17.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.3 | 12.8 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 12.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.7 | 10.4 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 10.0 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.5 | 8.6 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 8.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 8.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 7.0 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.7 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 20.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 14.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 9.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 9.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 8.7 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.2 | 8.1 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.3 | 7.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 6.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 6.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 14.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 14.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 13.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 11.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 11.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 10.3 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.2 | 9.3 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.3 | 9.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.2 | 7.5 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |