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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ESRRB_ESRRG
Z-value: 0.85
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Transcription factors associated with ESRRB_ESRRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRG | hg38_v1_chr1_-_217076889_217076997 | -0.21 | 3.0e-01 | Click! |
| ESRRB | hg38_v1_chr14_+_76376113_76376151 | -0.08 | 7.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRB_ESRRG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_123620496 Show fit | 1.85 |
ENST00000578202.1
|
myosin light chain kinase |
|
| chr3_-_123620571 Show fit | 1.81 |
ENST00000583087.5
|
myosin light chain kinase |
|
| chr14_-_58427134 Show fit | 1.30 |
ENST00000555930.6
|
translocase of inner mitochondrial membrane 9 |
|
| chr20_-_63499074 Show fit | 1.23 |
ENST00000217182.6
ENST00000642899.1 |
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr15_-_90932517 Show fit | 1.17 |
ENST00000330334.7
ENST00000394272.8 ENST00000559898.5 |
HD domain containing 3 |
|
| chr14_-_73760259 Show fit | 1.10 |
ENST00000286523.9
ENST00000435371.1 |
mitotic deacetylase associated SANT domain protein |
|
| chr2_-_105438503 Show fit | 0.98 |
ENST00000393352.7
ENST00000607522.1 |
four and a half LIM domains 2 |
|
| chr1_-_23177683 Show fit | 0.94 |
ENST00000302291.8
|
leucine zipper protein 1 |
|
| chr6_+_107028188 Show fit | 0.88 |
ENST00000311381.8
ENST00000405204.6 |
mitochondrial transcription rescue factor 1 |
|
| chr13_+_32586443 Show fit | 0.85 |
ENST00000315596.15
|
PDS5 cohesin associated factor B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.3 | 2.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 2.3 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 1.6 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 1.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 1.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 1.3 | GO:0006500 | N-terminal protein palmitoylation(GO:0006500) |
| 0.0 | 1.3 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.1 | 1.2 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.0 | 1.1 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.4 | 2.7 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 1.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 1.0 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 1.0 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.0 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.4 | 3.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.6 | 1.9 | GO:0008893 | guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(GO:0008893) diphosphoric monoester hydrolase activity(GO:0016794) |
| 0.0 | 1.6 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 1.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 1.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 1.1 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.0 | 1.1 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.0 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 2.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 0.8 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.6 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |