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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ETV2
Z-value: 0.80
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Transcription factors associated with ETV2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV2 | hg38_v1_chr19_+_35641728_35641793 | 0.56 | 3.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_103121457 Show fit | 2.41 |
ENST00000333007.8
|
TNF alpha induced protein 2 |
|
| chr6_-_31582415 Show fit | 2.39 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr11_+_2400488 Show fit | 1.97 |
ENST00000380996.9
ENST00000380992.5 ENST00000333256.11 ENST00000437110.5 ENST00000435795.5 |
tumor suppressing subtransferable candidate 4 |
|
| chr5_+_126423363 Show fit | 1.75 |
ENST00000285689.8
|
GRAM domain containing 2B |
|
| chr15_+_70892809 Show fit | 1.74 |
ENST00000260382.10
ENST00000560755.5 |
leucine rich repeat containing 49 |
|
| chr5_+_126423122 Show fit | 1.73 |
ENST00000515200.5
|
GRAM domain containing 2B |
|
| chr5_+_126423176 Show fit | 1.71 |
ENST00000542322.5
ENST00000544396.5 |
GRAM domain containing 2B |
|
| chr15_+_70892443 Show fit | 1.56 |
ENST00000443425.6
ENST00000560369.5 |
leucine rich repeat containing 49 |
|
| chr6_+_125919296 Show fit | 1.44 |
ENST00000444128.2
|
nuclear receptor coactivator 7 |
|
| chr6_+_125919210 Show fit | 1.43 |
ENST00000438495.6
|
nuclear receptor coactivator 7 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.1 | 2.9 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 2.7 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.1 | 2.6 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 2.6 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.3 | 2.4 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 2.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 2.1 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.3 | 1.8 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.3 | 1.7 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 2.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 1.7 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.6 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 1.5 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 1.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 1.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 1.2 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 3.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 3.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 3.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 2.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 2.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 2.0 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 2.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.3 | 1.7 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.2 | 1.6 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 2.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 2.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.1 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.0 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 1.0 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 1.8 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 1.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.7 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 1.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.3 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 1.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 1.1 | REACTOME KINESINS | Genes involved in Kinesins |