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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ETV4_ETS2
Z-value: 1.41
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Transcription factors associated with ETV4_ETS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETS2 | hg38_v1_chr21_+_38805968_38805983, hg38_v1_chr21_+_38805165_38805217, hg38_v1_chr21_+_38805895_38805951 | 0.52 | 7.9e-03 | Click! |
| ETV4 | hg38_v1_chr17_-_43545636_43545685 | 0.48 | 1.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV4_ETS2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_173205543 Show fit | 3.82 |
ENST00000367718.5
|
TNF superfamily member 4 |
|
| chr15_+_70892809 Show fit | 3.72 |
ENST00000260382.10
ENST00000560755.5 |
leucine rich repeat containing 49 |
|
| chr15_+_70892443 Show fit | 3.65 |
ENST00000443425.6
ENST00000560369.5 |
leucine rich repeat containing 49 |
|
| chr9_+_35732649 Show fit | 3.54 |
ENST00000353704.3
|
cAMP responsive element binding protein 3 |
|
| chr2_+_102418642 Show fit | 3.42 |
ENST00000264260.6
|
interleukin 18 receptor accessory protein |
|
| chr5_+_126423122 Show fit | 3.34 |
ENST00000515200.5
|
GRAM domain containing 2B |
|
| chr5_+_126423363 Show fit | 3.34 |
ENST00000285689.8
|
GRAM domain containing 2B |
|
| chr5_+_126423176 Show fit | 3.28 |
ENST00000542322.5
ENST00000544396.5 |
GRAM domain containing 2B |
|
| chr3_-_50340933 Show fit | 3.07 |
ENST00000616212.4
|
Ras association domain family member 1 |
|
| chr3_-_50340804 Show fit | 3.05 |
ENST00000359365.9
ENST00000357043.6 |
Ras association domain family member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.6 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.3 | 5.4 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.3 | 5.3 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 5.3 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 5.2 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.8 | 5.1 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 1.0 | 4.9 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.3 | 4.7 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 1.5 | 4.6 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.1 | 4.5 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 10.4 | GO:0005874 | microtubule(GO:0005874) |
| 0.1 | 7.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 6.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.7 | 5.8 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.6 | 5.1 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 5.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.6 | 4.9 | GO:0043196 | varicosity(GO:0043196) |
| 1.2 | 4.8 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.5 | 4.4 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 5.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 5.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 5.2 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 5.2 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.8 | 5.1 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.2 | 4.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 1.2 | 4.6 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 4.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 1.4 | 4.1 | GO:0035248 | alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 9.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 7.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 7.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 6.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 5.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 4.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 4.0 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 4.8 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.0 | 4.5 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 4.3 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 3.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 3.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 3.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 3.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 3.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |