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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ETV7
Z-value: 0.80
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Transcription factors associated with ETV7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV7 | hg38_v1_chr6_-_36387566_36387635 | 0.17 | 4.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV7
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_157269317 Show fit | 0.79 |
ENST00000618329.4
|
cytoplasmic FMR1 interacting protein 2 |
|
| chr10_-_88952763 Show fit | 0.78 |
ENST00000224784.10
|
actin alpha 2, smooth muscle |
|
| chr7_+_142656688 Show fit | 0.65 |
ENST00000390397.2
|
T cell receptor beta variable 24-1 |
|
| chr12_-_7444139 Show fit | 0.59 |
ENST00000416109.2
ENST00000313599.8 |
CD163 molecule like 1 |
|
| chr3_-_121660892 Show fit | 0.58 |
ENST00000428394.6
ENST00000314583.8 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr6_+_33391805 Show fit | 0.57 |
ENST00000428849.7
ENST00000450504.1 |
kinesin family member C1 |
|
| chr6_-_89217339 Show fit | 0.57 |
ENST00000454853.7
|
gamma-aminobutyric acid type A receptor subunit rho1 |
|
| chr7_+_127593727 Show fit | 0.57 |
ENST00000478821.1
ENST00000265825.6 |
fascin actin-bundling protein 3 |
|
| chr3_-_190862688 Show fit | 0.56 |
ENST00000442080.6
|
geminin coiled-coil domain containing |
|
| chr1_+_202462730 Show fit | 0.55 |
ENST00000290419.9
ENST00000491336.5 |
protein phosphatase 1 regulatory subunit 12B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.2 | GO:0097327 | response to antineoplastic agent(GO:0097327) |
| 0.1 | 1.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.2 | 0.8 | GO:0072144 | glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131) |
| 0.1 | 0.8 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 0.8 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.2 | 0.7 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 0.1 | 0.7 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.0 | 0.7 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 0.6 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.1 | 1.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 1.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.0 | GO:0031672 | A band(GO:0031672) |
| 0.2 | 0.9 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.1 | 0.9 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 0.8 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.7 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.6 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.5 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 1.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 1.2 | GO:0032440 | 2-alkenal reductase [NAD(P)] activity(GO:0032440) |
| 0.2 | 0.7 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.2 | 0.7 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.2 | 0.7 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 0.2 | 0.6 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.0 | 0.6 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 0.5 | GO:0051734 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.7 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.5 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.0 | 0.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |