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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for EZH2
Z-value: 0.73
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg38_v1_chr7_-_148883474_148883509 | 0.18 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_31582415 Show fit | 1.87 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr19_+_50649445 Show fit | 1.02 |
ENST00000425202.6
|
chromosome 19 open reading frame 81 |
|
| chr11_-_44310126 Show fit | 0.99 |
ENST00000652299.1
|
ALX homeobox 4 |
|
| chr11_-_8810635 Show fit | 0.96 |
ENST00000527510.5
ENST00000528527.5 ENST00000313726.11 ENST00000528523.5 |
DENN domain containing 2B |
|
| chr9_-_16728165 Show fit | 0.95 |
ENST00000603713.5
ENST00000603313.5 |
basonuclin 2 |
|
| chr4_-_76023489 Show fit | 0.81 |
ENST00000306602.3
|
C-X-C motif chemokine ligand 10 |
|
| chr19_+_45001430 Show fit | 0.81 |
ENST00000625761.2
ENST00000505236.1 ENST00000221452.13 |
RELB proto-oncogene, NF-kB subunit |
|
| chr14_+_23376765 Show fit | 0.77 |
ENST00000649278.1
|
CKLF like MARVEL transmembrane domain containing 5 |
|
| chr14_-_75981986 Show fit | 0.65 |
ENST00000238682.8
|
transforming growth factor beta 3 |
|
| chr7_-_22193728 Show fit | 0.63 |
ENST00000620335.4
|
Rap guanine nucleotide exchange factor 5 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.2 | 1.9 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 1.4 | GO:1901740 | negative regulation of myoblast fusion(GO:1901740) |
| 0.0 | 1.3 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.1 | 1.0 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.0 | 1.0 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 0.9 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 0.1 | 0.9 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.9 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.1 | 0.8 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 0.9 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 0.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.8 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.6 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 0.6 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.5 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 0.5 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 1.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 1.3 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 1.1 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 1.1 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.2 | 0.9 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.1 | 0.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.9 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 0.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.9 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 0.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |