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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for FIGLA
Z-value: 0.76
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Transcription factors associated with FIGLA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FIGLA | hg38_v1_chr2_-_70790643_70790643 | 0.07 | 7.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FIGLA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_41226648 Show fit | 5.28 |
ENST00000377721.3
|
keratin associated protein 9-2 |
|
| chr17_+_41237998 Show fit | 4.87 |
ENST00000254072.7
|
keratin associated protein 9-8 |
|
| chr6_-_31582415 Show fit | 2.13 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr1_-_12616762 Show fit | 1.95 |
ENST00000464917.5
|
dehydrogenase/reductase 3 |
|
| chr16_-_46831043 Show fit | 1.39 |
ENST00000565112.1
|
chromosome 16 open reading frame 87 |
|
| chr17_+_41105332 Show fit | 1.24 |
ENST00000391415.1
ENST00000617453.1 |
keratin associated protein 4-9 |
|
| chr7_-_11832190 Show fit | 1.00 |
ENST00000423059.9
ENST00000617773.1 |
thrombospondin type 1 domain containing 7A |
|
| chr22_-_42720813 Show fit | 0.91 |
ENST00000381278.4
|
alpha 1,4-galactosyltransferase (P blood group) |
|
| chr22_-_42720861 Show fit | 0.90 |
ENST00000642412.2
|
alpha 1,4-galactosyltransferase (P blood group) |
|
| chr14_-_54902807 Show fit | 0.86 |
ENST00000543643.6
ENST00000536224.2 ENST00000395514.5 ENST00000491895.7 |
GTP cyclohydrolase 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0031424 | keratinization(GO:0031424) |
| 0.1 | 2.8 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.2 | 2.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 1.9 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.4 | 1.8 | GO:0001575 | globoside metabolic process(GO:0001575) |
| 0.4 | 1.2 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.2 | 1.2 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.1 | 0.9 | GO:0014916 | tetrahydrobiopterin biosynthetic process(GO:0006729) regulation of lung blood pressure(GO:0014916) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.2 | 0.8 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.2 | 0.8 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 3.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 1.9 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 1.2 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 0.9 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.6 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.5 | GO:0042825 | TAP complex(GO:0042825) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.8 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 2.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 1.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.1 | 1.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 1.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 1.2 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 1.0 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.1 | 0.9 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 0.1 | 0.8 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.4 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.4 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.9 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.8 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.0 | 0.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.5 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.4 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |