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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for FIGLA

Z-value: 0.76

Motif logo

Transcription factors associated with FIGLA

Gene Symbol Gene ID Gene Info
ENSG00000183733.6 FIGLA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FIGLAhg38_v1_chr2_-_70790643_707906430.077.3e-01Click!

Activity profile of FIGLA motif

Sorted Z-values of FIGLA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FIGLA

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_+_41226648 5.28 ENST00000377721.3
keratin associated protein 9-2
chr17_+_41237998 4.87 ENST00000254072.7
keratin associated protein 9-8
chr6_-_31582415 2.13 ENST00000429299.3
ENST00000446745.2
lymphotoxin beta
chr1_-_12616762 1.95 ENST00000464917.5
dehydrogenase/reductase 3
chr16_-_46831043 1.39 ENST00000565112.1
chromosome 16 open reading frame 87
chr17_+_41105332 1.24 ENST00000391415.1
ENST00000617453.1
keratin associated protein 4-9
chr7_-_11832190 1.00 ENST00000423059.9
ENST00000617773.1
thrombospondin type 1 domain containing 7A
chr22_-_42720813 0.91 ENST00000381278.4
alpha 1,4-galactosyltransferase (P blood group)
chr22_-_42720861 0.90 ENST00000642412.2
alpha 1,4-galactosyltransferase (P blood group)
chr14_-_54902807 0.86 ENST00000543643.6
ENST00000536224.2
ENST00000395514.5
ENST00000491895.7
GTP cyclohydrolase 1
chr6_-_31728877 0.78 ENST00000437288.5
dimethylarginine dimethylaminohydrolase 2
chr17_+_70169516 0.76 ENST00000243457.4
potassium inwardly rectifying channel subfamily J member 2
chr1_+_25616780 0.76 ENST00000374332.9
mannosidase alpha class 1C member 1
chr16_+_4795378 0.75 ENST00000588606.5
small integral membrane protein 22
chr6_-_31729260 0.73 ENST00000375789.7
dimethylarginine dimethylaminohydrolase 2
chr16_+_4795357 0.70 ENST00000586005.6
small integral membrane protein 22
chr8_-_80080816 0.69 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
tumor protein D52
chr6_-_31729478 0.69 ENST00000436437.2
dimethylarginine dimethylaminohydrolase 2
chr11_-_33892010 0.68 ENST00000257818.3
LIM domain only 2
chr4_-_138242325 0.66 ENST00000280612.9
solute carrier family 7 member 11
chr2_-_177264686 0.62 ENST00000397062.8
ENST00000430047.1
nuclear factor, erythroid 2 like 2
chr17_+_63477052 0.62 ENST00000290866.10
ENST00000428043.5
angiotensin I converting enzyme
chr5_-_95284535 0.61 ENST00000515393.5
multiple C2 and transmembrane domain containing 1
chr4_-_89836213 0.60 ENST00000618500.4
ENST00000508895.5
synuclein alpha
chr6_-_31729785 0.58 ENST00000416410.6
dimethylarginine dimethylaminohydrolase 2
chr6_-_10419638 0.58 ENST00000319516.8
transcription factor AP-2 alpha
chr1_+_61077219 0.56 ENST00000407417.7
nuclear factor I A
chr14_+_50533026 0.56 ENST00000441560.6
atlastin GTPase 1
chr22_-_37486357 0.55 ENST00000356998.8
ENST00000416983.7
ENST00000424765.2
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_+_135181323 0.54 ENST00000367814.8
MYB proto-oncogene, transcription factor
chr12_-_13095664 0.52 ENST00000337630.10
ENST00000545699.1
germ cell associated 1
chr6_+_135181268 0.52 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB proto-oncogene, transcription factor
chr2_+_169733811 0.51 ENST00000392647.7
kelch like family member 23
chr1_-_16978276 0.50 ENST00000375534.7
microfibril associated protein 2
chr7_-_120857124 0.50 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
tetraspanin 12
chr1_-_54887161 0.50 ENST00000535035.6
ENST00000371269.9
ENST00000436604.2
24-dehydrocholesterol reductase
chr7_-_151210488 0.50 ENST00000644661.2
H2B.E variant histone 1
chr2_+_46297397 0.49 ENST00000263734.5
endothelial PAS domain protein 1
chr6_+_17281341 0.49 ENST00000379052.10
RNA binding motif protein 24
chr6_-_33314202 0.48 ENST00000426633.6
ENST00000467025.1
TAP binding protein
chr17_-_58527980 0.45 ENST00000583114.5
septin 4
chr13_+_31945826 0.43 ENST00000647500.1
FRY microtubule binding protein
chr9_-_22009272 0.42 ENST00000380142.5
ENST00000276925.7
cyclin dependent kinase inhibitor 2B
chr2_-_24360299 0.42 ENST00000361999.7
intersectin 2
chr7_+_20330893 0.42 ENST00000222573.5
integrin subunit beta 8
chr6_-_37258110 0.41 ENST00000357219.4
ENST00000652386.1
ENST00000652639.1
transmembrane protein 217
chr1_+_65792889 0.41 ENST00000341517.9
phosphodiesterase 4B
chr17_-_41168219 0.38 ENST00000391356.4
keratin associated protein 4-3
chr5_-_141878396 0.38 ENST00000503492.5
ENST00000287008.8
ENST00000394536.4
protocadherin 1
chr5_+_76819022 0.37 ENST00000296677.5
F2R like trypsin receptor 1
chr11_-_124762283 0.37 ENST00000444566.5
ENST00000278927.10
ENST00000435477.1
endothelial cell adhesion molecule
chr1_-_15944348 0.37 ENST00000444358.1
zinc finger and BTB domain containing 17
chr2_+_64454145 0.37 ENST00000238875.10
galectin like
chr3_-_50337438 0.36 ENST00000327761.7
Ras association domain family member 1
chr1_-_150697128 0.36 ENST00000427665.1
ENST00000271732.8
golgi phosphoprotein 3 like
chr16_-_46831134 0.36 ENST00000394806.6
ENST00000285697.9
chromosome 16 open reading frame 87
chr19_+_55485176 0.35 ENST00000205194.5
ENST00000591590.1
ENST00000587400.1
N-acetyltransferase 14 (putative)
chr18_+_58045683 0.35 ENST00000592846.5
ENST00000675801.1
NEDD4 like E3 ubiquitin protein ligase
chr7_-_100101333 0.34 ENST00000303887.10
minichromosome maintenance complex component 7
chr19_-_18280806 0.33 ENST00000600972.1
JunD proto-oncogene, AP-1 transcription factor subunit
chr7_+_12687625 0.33 ENST00000651779.1
ENST00000404894.1
ADP ribosylation factor like GTPase 4A
chr19_-_42217667 0.32 ENST00000336034.8
ENST00000596251.6
ENST00000598200.1
ENST00000598727.5
death effector domain containing 2
chr14_-_50532590 0.32 ENST00000013125.9
mitogen-activated protein kinase kinase kinase kinase 5
chr19_-_49423441 0.32 ENST00000270631.2
parathyroid hormone 2
chr15_+_88639009 0.32 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr17_+_41249687 0.31 ENST00000334109.3
keratin associated protein 9-4
chr6_+_31815532 0.31 ENST00000375651.7
ENST00000608703.1
heat shock protein family A (Hsp70) member 1A
chr5_+_57175803 0.31 ENST00000511209.5
GC-rich promoter binding protein 1
chr19_+_11547840 0.30 ENST00000588935.1
calponin 1
chr2_-_174764407 0.30 ENST00000409219.5
ENST00000409542.5
cholinergic receptor nicotinic alpha 1 subunit
chr11_+_66011994 0.30 ENST00000312134.3
cystatin E/M
chr18_+_58045642 0.30 ENST00000676223.1
ENST00000675147.1
NEDD4 like E3 ubiquitin protein ligase
chr11_-_66347560 0.30 ENST00000311181.5
beta-1,4-glucuronyltransferase 1
chr2_-_24360445 0.29 ENST00000443927.5
ENST00000406921.7
ENST00000412011.5
ENST00000355123.9
intersectin 2
chr5_+_69492767 0.29 ENST00000681041.1
ENST00000680098.1
ENST00000680784.1
ENST00000396442.7
ENST00000681895.1
occludin
chr1_-_154956086 0.28 ENST00000368463.8
ENST00000368460.7
ENST00000368465.5
PBX homeobox interacting protein 1
chr19_+_35248879 0.28 ENST00000347609.8
lipolysis stimulated lipoprotein receptor
chr22_+_22811737 0.28 ENST00000390315.3
immunoglobulin lambda variable 3-10
chr13_+_26254098 0.28 ENST00000381527.8
cyclin dependent kinase 8
chr15_+_88638947 0.27 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr2_-_29074515 0.27 ENST00000331664.6
photoreceptor cilium actin regulator
chr7_-_100100716 0.27 ENST00000354230.7
ENST00000425308.5
minichromosome maintenance complex component 7
chr7_-_93226449 0.26 ENST00000394468.7
ENST00000453812.2
HEPACAM family member 2
chr12_+_32502114 0.26 ENST00000682739.1
ENST00000427716.7
ENST00000583694.2
FYVE, RhoGEF and PH domain containing 4
chr8_-_92017292 0.26 ENST00000521553.5
RUNX1 partner transcriptional co-repressor 1
chr17_+_29568591 0.26 ENST00000581411.6
ENST00000301057.8
tumor protein p53 inducible protein 13
chr3_+_124584625 0.26 ENST00000291478.9
ENST00000682363.1
ENST00000454902.1
kalirin RhoGEF kinase
chr7_+_130380339 0.26 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
carboxypeptidase A1
chr12_-_79690522 0.25 ENST00000552637.1
pro-apoptotic WT1 regulator
chr6_-_39322688 0.25 ENST00000437525.3
potassium two pore domain channel subfamily K member 16
chr5_-_16936231 0.25 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
myosin X
chr6_-_136550407 0.24 ENST00000354570.8
microtubule associated protein 7
chr1_-_156705764 0.24 ENST00000621784.4
ENST00000368220.1
cellular retinoic acid binding protein 2
chr17_-_58352139 0.23 ENST00000225504.8
SPT4 homolog, DSIF elongation factor subunit
chr1_-_156705575 0.23 ENST00000368222.8
cellular retinoic acid binding protein 2
chr19_+_35248728 0.23 ENST00000602003.1
ENST00000360798.7
ENST00000354900.7
lipolysis stimulated lipoprotein receptor
chr19_+_35248694 0.23 ENST00000361790.7
lipolysis stimulated lipoprotein receptor
chr1_+_155078829 0.23 ENST00000368408.4
ephrin A3
chr17_+_9645502 0.22 ENST00000285199.12
ubiquitin specific peptidase 43
chr7_+_131110087 0.22 ENST00000421797.6
muskelin 1
chr2_-_219571529 0.22 ENST00000404537.6
obscurin like cytoskeletal adaptor 1
chr15_+_75347030 0.22 ENST00000566313.5
ENST00000355059.9
ENST00000568059.1
ENST00000568881.1
nei like DNA glycosylase 1
chr11_+_111918900 0.22 ENST00000278601.6
chromosome 11 open reading frame 52
chr7_-_130441136 0.22 ENST00000675596.1
ENST00000676312.1
centrosomal protein 41
chr19_+_35248656 0.22 ENST00000621372.4
lipolysis stimulated lipoprotein receptor
chr13_+_41061481 0.22 ENST00000379487.5
WW domain binding protein 4
chr9_+_87497852 0.22 ENST00000408954.8
death associated protein kinase 1
chr19_+_35248375 0.22 ENST00000602122.5
lipolysis stimulated lipoprotein receptor
chr16_+_53820 0.22 ENST00000293861.8
ENST00000383018.7
ENST00000417493.1
small nuclear ribonucleoprotein U11/U12 subunit 25
chr1_-_17439657 0.22 ENST00000375436.9
regulator of chromosome condensation 2
chr3_+_50155024 0.22 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
semaphorin 3F
chrX_-_30308333 0.22 ENST00000378963.1
nuclear receptor subfamily 0 group B member 1
chr3_-_48556785 0.22 ENST00000232375.8
ENST00000383734.6
ENST00000416568.5
ENST00000412035.5
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr7_-_85187039 0.22 ENST00000284136.11
semaphorin 3D
chr16_+_283157 0.21 ENST00000219406.11
ENST00000404312.5
ENST00000456379.1
protein disulfide isomerase family A member 2
chr11_+_68312542 0.21 ENST00000294304.12
LDL receptor related protein 5
chr9_-_131531178 0.21 ENST00000372210.7
ENST00000372211.7
uridine-cytidine kinase 1
chr14_-_20454741 0.21 ENST00000206542.9
ENST00000553640.3
O-sialoglycoprotein endopeptidase
chr12_-_75209701 0.21 ENST00000350228.6
ENST00000298972.5
potassium voltage-gated channel subfamily C member 2
chr12_-_75209422 0.21 ENST00000393288.2
ENST00000540018.5
potassium voltage-gated channel subfamily C member 2
chr5_-_151087131 0.21 ENST00000315050.11
ENST00000523338.5
ENST00000522100.5
TNFAIP3 interacting protein 1
chr5_-_160312524 0.21 ENST00000520748.1
ENST00000257536.13
ENST00000393977.7
cyclin J like
chr19_-_45768627 0.20 ENST00000560160.1
SIX homeobox 5
chr2_-_162152239 0.20 ENST00000418842.7
glucagon
chr6_+_33204645 0.20 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr15_-_34336749 0.20 ENST00000397707.6
ENST00000560611.5
solute carrier family 12 member 6
chr1_-_45686501 0.20 ENST00000355105.8
ENST00000290795.7
GC-rich promoter binding protein 1 like 1
chr19_-_50952942 0.19 ENST00000594846.1
ENST00000336334.8
kallikrein related peptidase 5
chr3_+_105367212 0.19 ENST00000472644.6
activated leukocyte cell adhesion molecule
chr12_-_75209814 0.19 ENST00000549446.6
potassium voltage-gated channel subfamily C member 2
chr20_+_45416084 0.19 ENST00000279035.14
ENST00000543458.7
ENST00000372689.9
ENST00000639499.1
ENST00000279036.12
ENST00000638594.1
ENST00000638489.1
ENST00000638353.1
ENST00000639382.1
ENST00000640210.1
ENST00000639235.1
ENST00000638478.1
ENST00000432270.2
ENST00000545755.3
ENST00000640324.1
phosphatidylinositol glycan anchor biosynthesis class T
chr14_-_57866075 0.19 ENST00000556826.6
solute carrier family 35 member F4
chr12_+_47963557 0.19 ENST00000256686.10
ENST00000549288.5
ENST00000429772.7
ENST00000552561.5
ENST00000546749.5
ENST00000552546.5
ENST00000550552.5
transmembrane protein 106C
chr17_-_73092657 0.19 ENST00000580557.5
ENST00000579732.5
ENST00000578620.1
ENST00000542342.6
ENST00000255559.7
ENST00000579018.5
solute carrier family 39 member 11
chr13_-_20192928 0.19 ENST00000382848.5
gap junction protein beta 2
chr4_-_176195563 0.18 ENST00000280191.7
spermatogenesis associated 4
chr19_-_39391137 0.18 ENST00000595564.5
PAF1 homolog, Paf1/RNA polymerase II complex component
chr22_+_49960760 0.18 ENST00000360612.5
Pim-3 proto-oncogene, serine/threonine kinase
chr10_+_102854251 0.18 ENST00000339834.10
ENST00000369883.3
BLOC-1 related complex subunit 7
chr3_+_105366877 0.18 ENST00000306107.9
activated leukocyte cell adhesion molecule
chr20_+_45416551 0.18 ENST00000639292.1
phosphatidylinositol glycan anchor biosynthesis class T
chr5_-_160312756 0.18 ENST00000644313.1
cyclin J like
chr4_-_176269213 0.18 ENST00000296525.7
ankyrin repeat and SOCS box containing 5
chr12_-_52834307 0.17 ENST00000330553.6
keratin 79
chr11_-_35418966 0.17 ENST00000531628.2
solute carrier family 1 member 2
chr6_+_44216914 0.17 ENST00000573382.3
ENST00000576476.1
myomixer, myoblast fusion factor
chr12_-_13095628 0.17 ENST00000457134.6
ENST00000537302.5
germ cell associated 1
chr3_-_51967410 0.17 ENST00000461554.6
ENST00000483411.5
ENST00000461544.2
ENST00000355852.6
poly(rC) binding protein 4
chr19_+_50432885 0.17 ENST00000357701.6
myosin binding protein C2
chr3_+_127915226 0.17 ENST00000405109.5
kelch repeat and BTB domain containing 12
chr6_+_157981826 0.17 ENST00000355585.9
ENST00000640338.1
ENST00000367113.5
synaptojanin 2
chr11_-_35419098 0.17 ENST00000606205.6
ENST00000645303.1
solute carrier family 1 member 2
chr7_+_50308672 0.17 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKAROS family zinc finger 1
chr11_-_119381629 0.17 ENST00000260187.7
ENST00000455332.6
ubiquitin specific peptidase 2
chr15_+_67254825 0.16 ENST00000629425.2
IQ motif containing H
chr14_+_22271921 0.16 ENST00000390464.2
T cell receptor alpha variable 38-1
chr11_+_44726811 0.16 ENST00000533202.5
ENST00000520358.7
ENST00000533080.5
ENST00000520999.6
tetraspanin 18
chr5_+_141489066 0.16 ENST00000252087.3
protocadherin gamma subfamily C, 5
chr3_+_68006224 0.16 ENST00000496687.1
TAFA chemokine like family member 1
chr11_-_44950151 0.16 ENST00000533940.5
ENST00000533937.1
tumor protein p53 inducible protein 11
chr6_-_39322540 0.16 ENST00000425054.6
ENST00000373227.8
ENST00000373229.9
potassium two pore domain channel subfamily K member 16
chr19_-_43504711 0.16 ENST00000601646.1
pleckstrin homology like domain family B member 3
chr11_-_35419462 0.16 ENST00000643522.1
solute carrier family 1 member 2
chr6_+_108848387 0.16 ENST00000368972.7
ENST00000392644.9
armadillo repeat containing 2
chr19_-_18522051 0.16 ENST00000262809.9
elongation factor for RNA polymerase II
chr18_-_55587335 0.16 ENST00000638154.3
transcription factor 4
chr14_-_106511856 0.16 ENST00000390622.2
immunoglobulin heavy variable 1-46
chr6_+_135181361 0.15 ENST00000527615.5
ENST00000420123.6
ENST00000525369.5
ENST00000528774.5
ENST00000533624.5
ENST00000534044.5
ENST00000534121.5
MYB proto-oncogene, transcription factor
chr8_-_126557691 0.15 ENST00000652209.1
LRAT domain containing 2
chr3_+_127915469 0.15 ENST00000407609.7
kelch repeat and BTB domain containing 12
chr4_+_5711154 0.15 ENST00000264956.11
ENST00000509451.1
EvC ciliary complex subunit 1
chr4_-_139302516 0.15 ENST00000394228.5
ENST00000539387.5
NADH:ubiquinone oxidoreductase subunit C1
chr2_-_164841410 0.15 ENST00000342193.8
ENST00000375458.6
cordon-bleu WH2 repeat protein like 1
chr2_-_174764436 0.15 ENST00000409323.1
ENST00000261007.9
ENST00000348749.9
ENST00000672640.1
cholinergic receptor nicotinic alpha 1 subunit
chrX_+_71223216 0.15 ENST00000361726.7
gap junction protein beta 1
chr17_+_42833390 0.15 ENST00000590720.6
ENST00000586114.5
ENST00000585805.5
ENST00000441946.6
ENST00000591152.5
ENST00000589469.5
ENST00000293362.7
ENST00000592169.2
proteasome activator subunit 3
chr11_-_35419213 0.14 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
solute carrier family 1 member 2
chr22_+_22343185 0.14 ENST00000427632.2
immunoglobulin lambda variable 9-49
chr12_-_13095798 0.14 ENST00000396302.7
germ cell associated 1
chr3_+_52420955 0.14 ENST00000465863.1
PHD finger protein 7
chr17_-_47957824 0.14 ENST00000300557.3
proline rich 15 like
chr1_-_154870264 0.14 ENST00000618040.4
ENST00000271915.9
potassium calcium-activated channel subfamily N member 3
chr16_+_6483379 0.14 ENST00000552089.5
RNA binding fox-1 homolog 1
chr11_+_67586104 0.14 ENST00000495996.1
glutathione S-transferase pi 1
chr17_-_7241787 0.14 ENST00000577035.5
GABA type A receptor-associated protein
chr6_+_31971831 0.14 ENST00000375331.7
ENST00000375333.3
serine/threonine kinase 19
chrX_+_111096211 0.13 ENST00000372010.5
ENST00000519681.5
p21 (RAC1) activated kinase 3
chr1_+_209768597 0.13 ENST00000487271.5
ENST00000477431.1
TRAF3 interacting protein 3
chr3_-_49813880 0.13 ENST00000333486.4
ubiquitin like modifier activating enzyme 7
chr4_+_168497066 0.13 ENST00000261509.10
palladin, cytoskeletal associated protein
chr4_+_168497044 0.13 ENST00000505667.6
palladin, cytoskeletal associated protein
chr13_-_41061373 0.13 ENST00000405737.2
E74 like ETS transcription factor 1
chr6_+_41921491 0.13 ENST00000230340.9
bystin like
chr6_+_150683593 0.13 ENST00000644968.1
pleckstrin homology and RhoGEF domain containing G1
chr11_-_65862026 0.13 ENST00000532134.5
cofilin 1
chr17_-_41382298 0.13 ENST00000394001.3
keratin 34
chr18_-_72865680 0.12 ENST00000397929.5
neuropilin and tolloid like 1
chr19_+_7914823 0.12 ENST00000565886.2
transforming growth factor beta receptor 3 like
chr16_-_69385570 0.12 ENST00000566750.5
telomeric repeat binding factor 2
chrX_+_129738942 0.12 ENST00000371106.4
X-prolyl aminopeptidase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.4 1.8 GO:0001575 globoside metabolic process(GO:0001575)
0.2 2.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.2 1.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 0.4 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.2 0.8 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.2 0.8 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.2 0.6 GO:0046223 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.2 0.6 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.2 0.6 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.6 GO:0003409 optic cup structural organization(GO:0003409)
0.1 2.8 GO:0006527 arginine catabolic process(GO:0006527)
0.1 1.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.5 GO:0050823 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.1 0.4 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.1 0.9 GO:0014916 tetrahydrobiopterin biosynthetic process(GO:0006729) regulation of lung blood pressure(GO:0014916) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.6 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.4 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 0.5 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.2 GO:1903823 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.1 0.5 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.2 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.5 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.3 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0035732 nitric oxide storage(GO:0035732)
0.0 0.7 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0048625 norepinephrine metabolic process(GO:0042415) surfactant homeostasis(GO:0043129) myoblast fate commitment(GO:0048625)
0.0 0.3 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.2 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.2 GO:0044752 response to human chorionic gonadotropin(GO:0044752)
0.0 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.4 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:0051511 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.2 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.2 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.2 GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.0 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.7 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.3 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.2 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.3 GO:0046959 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:1903892 negative regulation of ATF6-mediated unfolded protein response(GO:1903892)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.7 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 4.0 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0097698 telomere maintenance via base-excision repair(GO:0097698)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.6 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.2 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.3 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 0.1 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 0.4 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.4 GO:0002076 osteoblast development(GO:0002076)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.0 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.4 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0003360 brainstem development(GO:0003360)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 1.2 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 3.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.2 GO:0032044 DSIF complex(GO:0032044)
0.0 3.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.2 GO:0035363 histone locus body(GO:0035363)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.0 GO:0036117 hyaluranon cable(GO:0036117)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 GO:0016403 dimethylargininase activity(GO:0016403)
0.2 0.6 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 1.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.7 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.6 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.1 1.8 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.6 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.5 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 0.9 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.4 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0035730 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
0.0 2.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.5 GO:0019841 retinol binding(GO:0019841)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0005243 gap junction channel activity(GO:0005243)
0.0 1.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 1.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.8 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events