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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for FOSB
Z-value: 0.66
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Transcription factors associated with FOSB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg38_v1_chr19_+_45469841_45469913 | 0.23 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_94541636 Show fit | 1.86 |
ENST00000370207.4
|
coagulation factor III, tissue factor |
|
| chr1_-_94541746 Show fit | 1.86 |
ENST00000334047.12
|
coagulation factor III, tissue factor |
|
| chr3_-_149576203 Show fit | 1.53 |
ENST00000472417.1
|
WW domain containing transcription regulator 1 |
|
| chr4_+_73740541 Show fit | 1.21 |
ENST00000401931.1
ENST00000307407.8 |
C-X-C motif chemokine ligand 8 |
|
| chr3_-_18424533 Show fit | 1.18 |
ENST00000417717.6
|
SATB homeobox 1 |
|
| chr11_-_33892010 Show fit | 1.05 |
ENST00000257818.3
|
LIM domain only 2 |
|
| chr16_-_4614876 Show fit | 0.94 |
ENST00000591401.5
ENST00000283474.12 ENST00000591897.5 |
UBA like domain containing 1 |
|
| chr5_-_177496845 Show fit | 0.93 |
ENST00000506537.1
|
PDZ and LIM domain 7 |
|
| chr3_-_31981228 Show fit | 0.92 |
ENST00000396556.7
ENST00000438237.6 |
oxysterol binding protein like 10 |
|
| chr16_-_4614859 Show fit | 0.91 |
ENST00000587615.1
ENST00000587649.1 ENST00000590965.1 |
UBA like domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.7 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.1 | 1.9 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.3 | 1.8 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.0 | 1.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 1.7 | GO:0000305 | response to oxygen radical(GO:0000305) |
| 0.0 | 1.6 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.1 | 1.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 1.3 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 1.2 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 1.2 | GO:0071461 | cellular response to redox state(GO:0071461) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 1.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.2 | 1.8 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 1.5 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 1.2 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 1.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 0.5 | GO:0044393 | microspike(GO:0044393) cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 0.5 | GO:0097149 | centralspindlin complex(GO:0097149) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.3 | 1.8 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 1.5 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.0 | 1.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 1.2 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 1.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 1.2 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 1.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 0.9 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 0.9 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 3.3 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 0.9 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.7 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.7 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.6 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |