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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for FOSB

Z-value: 0.66

Motif logo

Transcription factors associated with FOSB

Gene Symbol Gene ID Gene Info
ENSG00000125740.14 FOSB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOSBhg38_v1_chr19_+_45469841_454699130.232.8e-01Click!

Activity profile of FOSB motif

Sorted Z-values of FOSB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSB

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_94541636 1.86 ENST00000370207.4
coagulation factor III, tissue factor
chr1_-_94541746 1.86 ENST00000334047.12
coagulation factor III, tissue factor
chr3_-_149576203 1.53 ENST00000472417.1
WW domain containing transcription regulator 1
chr4_+_73740541 1.21 ENST00000401931.1
ENST00000307407.8
C-X-C motif chemokine ligand 8
chr3_-_18424533 1.18 ENST00000417717.6
SATB homeobox 1
chr11_-_33892010 1.05 ENST00000257818.3
LIM domain only 2
chr16_-_4614876 0.94 ENST00000591401.5
ENST00000283474.12
ENST00000591897.5
UBA like domain containing 1
chr5_-_177496845 0.93 ENST00000506537.1
PDZ and LIM domain 7
chr3_-_31981228 0.92 ENST00000396556.7
ENST00000438237.6
oxysterol binding protein like 10
chr16_-_4614859 0.91 ENST00000587615.1
ENST00000587649.1
ENST00000590965.1
UBA like domain containing 1
chr15_+_67166019 0.90 ENST00000537194.6
SMAD family member 3
chr4_-_88158605 0.89 ENST00000237612.8
ATP binding cassette subfamily G member 2 (Junior blood group)
chr15_+_67125707 0.87 ENST00000540846.6
SMAD family member 3
chr5_-_177496802 0.87 ENST00000506161.5
PDZ and LIM domain 7
chr22_-_19881369 0.82 ENST00000462330.5
thioredoxin reductase 2
chr22_-_19881163 0.81 ENST00000485358.5
thioredoxin reductase 2
chr3_-_142028597 0.74 ENST00000467667.5
transcription factor Dp-2
chr2_+_169069537 0.73 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
dehydrogenase/reductase 9
chr2_+_28392802 0.69 ENST00000379619.5
ENST00000264716.9
FOS like 2, AP-1 transcription factor subunit
chr19_+_48874318 0.68 ENST00000600406.1
protein phosphatase 1 regulatory subunit 15A
chr18_+_44700796 0.68 ENST00000677130.1
SET binding protein 1
chr4_+_107824555 0.64 ENST00000394684.8
sphingomyelin synthase 2
chr3_-_142029108 0.64 ENST00000497579.5
transcription factor Dp-2
chr6_+_73695779 0.62 ENST00000422508.6
ENST00000437994.6
CD109 molecule
chr6_+_130366281 0.61 ENST00000617887.4
transmembrane protein 200A
chr20_+_36154630 0.61 ENST00000338074.7
ENST00000636016.2
ENST00000373945.5
erythrocyte membrane protein band 4.1 like 1
chr1_-_85404494 0.61 ENST00000633113.1
dimethylarginine dimethylaminohydrolase 1
chr6_+_155216637 0.60 ENST00000275246.11
TIAM Rac1 associated GEF 2
chr9_-_70414657 0.59 ENST00000377126.4
Kruppel like factor 9
chr11_+_128694052 0.58 ENST00000527786.7
ENST00000534087.3
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_73696145 0.58 ENST00000287097.6
CD109 molecule
chr6_-_83709141 0.57 ENST00000521743.5
synaptosome associated protein 91
chr3_+_172754457 0.53 ENST00000441497.6
epithelial cell transforming 2
chr11_+_128693887 0.52 ENST00000281428.12
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_130365958 0.51 ENST00000296978.4
transmembrane protein 200A
chr6_-_83709019 0.51 ENST00000519779.5
ENST00000369694.6
ENST00000195649.10
synaptosome associated protein 91
chr3_-_142028617 0.50 ENST00000477292.5
ENST00000478006.5
ENST00000495310.5
ENST00000486111.5
transcription factor Dp-2
chr14_+_73058591 0.48 ENST00000525161.5
RNA binding motif protein 25
chr12_-_14961610 0.47 ENST00000542276.1
Rho GDP dissociation inhibitor beta
chr1_-_220089818 0.46 ENST00000498791.6
ENST00000480959.6
3'(2'), 5'-bisphosphate nucleotidase 1
chr6_-_158818225 0.46 ENST00000337147.11
ezrin
chr17_+_37491464 0.45 ENST00000613659.1
dual specificity phosphatase 14
chr5_-_88731827 0.45 ENST00000627170.2
myocyte enhancer factor 2C
chr8_-_8893548 0.44 ENST00000276282.7
malignant fibrous histiocytoma amplified sequence 1
chr12_-_95116967 0.44 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr14_+_103334803 0.44 ENST00000561325.5
ENST00000392715.6
ENST00000559130.5
ENST00000559532.5
ENST00000558506.1
eukaryotic translation initiation factor 5
chr2_-_65366650 0.44 ENST00000443619.6
sprouty related EVH1 domain containing 2
chr12_-_14961256 0.43 ENST00000541380.5
Rho GDP dissociation inhibitor beta
chr2_-_237590660 0.43 ENST00000409576.1
RAB17, member RAS oncogene family
chr14_-_22957100 0.42 ENST00000555367.5
HAUS augmin like complex subunit 4
chr14_-_22957061 0.41 ENST00000557591.5
ENST00000541587.6
ENST00000490506.5
ENST00000554406.1
HAUS augmin like complex subunit 4
chr14_-_22957128 0.41 ENST00000342454.12
ENST00000555986.5
ENST00000554516.5
ENST00000347758.6
ENST00000206474.11
ENST00000555040.5
HAUS augmin like complex subunit 4
chr3_-_125055987 0.40 ENST00000311127.9
heart development protein with EGF like domains 1
chr5_+_175861628 0.40 ENST00000509837.5
complexin 2
chr7_+_134843884 0.38 ENST00000445569.6
caldesmon 1
chr7_+_150368189 0.38 ENST00000519397.1
ENST00000479668.5
replication initiator 1
chr12_-_51009264 0.37 ENST00000545993.7
solute carrier family 11 member 2
chr12_+_10213417 0.37 ENST00000546017.5
ENST00000535576.5
ENST00000539170.5
GABA type A receptor associated protein like 1
chr6_+_2988606 0.36 ENST00000380472.7
ENST00000605901.1
ENST00000454015.1
N-ribosyldihydronicotinamide:quinone reductase 2
long intergenic non-protein coding RNA 1011
chr3_-_151316795 0.36 ENST00000260843.5
G protein-coupled receptor 87
chr20_+_49812697 0.36 ENST00000417961.5
solute carrier family 9 member A8
chr20_+_49812818 0.36 ENST00000361573.3
solute carrier family 9 member A8
chr11_-_119195487 0.36 ENST00000503566.6
coiled-coil domain containing 153
chr8_-_124372686 0.35 ENST00000297632.8
transmembrane protein 65
chr2_-_203535253 0.35 ENST00000457812.5
ENST00000319170.10
ENST00000630330.2
ENST00000308091.8
ENST00000453034.5
ENST00000420371.2
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr19_+_46601296 0.33 ENST00000598871.5
ENST00000291295.14
ENST00000594523.5
calmodulin 3
chr11_+_102112445 0.33 ENST00000524575.5
Yes1 associated transcriptional regulator
chr19_+_46601237 0.33 ENST00000597743.5
calmodulin 3
chr17_+_21288029 0.33 ENST00000526076.6
ENST00000361818.9
ENST00000316920.10
mitogen-activated protein kinase kinase 3
chr22_-_31662180 0.33 ENST00000435900.5
phosphatidylserine decarboxylase
chr11_-_67356970 0.33 ENST00000532830.5
DNA polymerase delta 4, accessory subunit
chr12_-_14961559 0.33 ENST00000228945.9
ENST00000541546.5
Rho GDP dissociation inhibitor beta
chr1_+_89524871 0.32 ENST00000639264.1
leucine rich repeat containing 8 VRAC subunit B
chr7_-_98869920 0.31 ENST00000345589.4
transmembrane protein 130
chr17_-_29176752 0.31 ENST00000533112.5
myosin XVIIIA
chr17_+_76738012 0.30 ENST00000590514.5
major facilitator superfamily domain containing 11
chr17_-_41612757 0.30 ENST00000301653.9
ENST00000593067.1
keratin 16
chr7_-_98870006 0.30 ENST00000339375.9
transmembrane protein 130
chr6_+_32153441 0.29 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
palmitoyl-protein thioesterase 2
chr3_+_184176949 0.29 ENST00000432591.5
ENST00000431779.5
ENST00000621863.4
adaptor related protein complex 2 subunit mu 1
chr17_-_41786688 0.29 ENST00000310706.9
ENST00000393931.8
ENST00000424457.5
ENST00000591690.5
junction plakoglobin
chr3_-_18425295 0.29 ENST00000338745.11
ENST00000450898.1
SATB homeobox 1
chr7_+_143222037 0.28 ENST00000408947.4
taste 2 receptor member 40
chr5_+_54455661 0.28 ENST00000302005.3
heat shock protein family B (small) member 3
chr15_-_44194407 0.27 ENST00000484674.5
FERM domain containing 5
chr1_-_12616762 0.27 ENST00000464917.5
dehydrogenase/reductase 3
chr7_+_1044542 0.25 ENST00000444847.2
G protein-coupled receptor 146
chr2_+_190343561 0.25 ENST00000322522.8
ENST00000392329.7
ENST00000430311.5
inositol polyphosphate-1-phosphatase
chr1_+_100538131 0.25 ENST00000315033.5
G protein-coupled receptor 88
chr2_-_144517663 0.24 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
zinc finger E-box binding homeobox 2
chr6_-_24877262 0.24 ENST00000378023.8
ENST00000540914.5
RHO family interacting cell polarization regulator 2
chr7_+_100852706 0.24 ENST00000354161.8
ENST00000540482.5
ENST00000418037.5
ENST00000415287.5
ENST00000416675.5
solute carrier family 12 member 9
chr7_+_32979445 0.24 ENST00000418354.5
ENST00000490776.3
FKBP prolyl isomerase 9
chr10_-_21174187 0.23 ENST00000417816.2
nebulette
chr1_+_26543106 0.23 ENST00000530003.5
ribosomal protein S6 kinase A1
chr2_+_102001966 0.23 ENST00000457817.5
interleukin 1 receptor type 2
chr16_-_28482634 0.23 ENST00000637378.1
novel protein
chr3_+_184176778 0.23 ENST00000439647.5
adaptor related protein complex 2 subunit mu 1
chr16_+_2033264 0.23 ENST00000565855.5
ENST00000566198.1
SLC9A3 regulator 2
chr7_+_2647703 0.23 ENST00000403167.5
tweety family member 3
chr18_-_55351977 0.22 ENST00000643689.1
transcription factor 4
chr17_-_28717792 0.21 ENST00000636772.1
RAB34, member RAS oncogene family
chr15_+_75206398 0.21 ENST00000565074.1
chromosome 15 open reading frame 39
chr17_+_76737387 0.21 ENST00000590393.1
ENST00000355954.7
ENST00000586689.5
ENST00000587661.5
ENST00000593181.5
ENST00000336509.8
major facilitator superfamily domain containing 11
chr6_+_44227025 0.21 ENST00000371708.1
solute carrier family 29 member 1 (Augustine blood group)
chr18_-_48137295 0.21 ENST00000535628.6
zinc finger and BTB domain containing 7C
chr17_+_82359245 0.21 ENST00000333437.5
testis expressed 19
chr13_-_40982880 0.21 ENST00000635415.1
E74 like ETS transcription factor 1
chr6_+_33075952 0.21 ENST00000418931.7
major histocompatibility complex, class II, DP beta 1
chr11_-_47176851 0.21 ENST00000629231.2
ENST00000526342.5
ENST00000528444.5
ENST00000530596.5
ENST00000525398.5
ENST00000524782.6
ENST00000527927.5
ENST00000525314.5
ADP ribosylation factor GTPase activating protein 2
chr11_-_47185840 0.21 ENST00000539589.5
ENST00000528462.5
protein kinase C and casein kinase substrate in neurons 3
chr1_-_51331315 0.21 ENST00000262676.9
tetratricopeptide repeat domain 39A
chr22_+_29306582 0.21 ENST00000616432.4
ENST00000416823.1
ENST00000428622.1
growth arrest specific 2 like 1
chr19_+_36140059 0.21 ENST00000246533.8
ENST00000587718.5
ENST00000592483.5
ENST00000590874.5
ENST00000588815.5
calpain small subunit 1
chr12_-_48957365 0.20 ENST00000398092.4
ENST00000539611.1
novel protein
ADP ribosylation factor 3
chr10_+_132066003 0.19 ENST00000657318.1
ENST00000666210.1
Janus kinase and microtubule interacting protein 3
chr18_+_63775369 0.19 ENST00000540675.5
serpin family B member 7
chr17_-_28718405 0.19 ENST00000430132.6
ENST00000301043.10
ENST00000412625.5
RAB34, member RAS oncogene family
chr8_-_17895487 0.19 ENST00000427924.5
ENST00000381841.4
fibrinogen like 1
chr3_-_98522869 0.19 ENST00000502288.5
ENST00000512147.5
ENST00000341181.11
ENST00000510541.5
ENST00000503621.5
ENST00000511081.5
ENST00000507874.5
ENST00000502299.5
ENST00000508659.5
ENST00000510545.5
ENST00000511667.5
ENST00000394185.6
claudin domain containing 1
chr2_-_217842154 0.19 ENST00000446688.5
tensin 1
chr18_+_23873000 0.19 ENST00000269217.11
ENST00000587184.5
laminin subunit alpha 3
chr11_+_67583742 0.18 ENST00000398603.6
glutathione S-transferase pi 1
chr3_-_98522514 0.18 ENST00000503004.5
ENST00000506575.1
ENST00000513452.5
ENST00000515620.5
claudin domain containing 1
chr16_+_28863812 0.18 ENST00000684370.1
SH2B adaptor protein 1
chr17_+_77319465 0.18 ENST00000329047.13
septin 9
chr10_+_132065937 0.18 ENST00000658847.1
ENST00000666974.1
Janus kinase and microtubule interacting protein 3
chr7_+_1086800 0.18 ENST00000413368.5
ENST00000397092.5
ENST00000297469.3
G protein-coupled estrogen receptor 1
chr9_-_34662654 0.18 ENST00000259631.5
C-C motif chemokine ligand 27
chr10_+_133087883 0.17 ENST00000392607.8
adhesion G protein-coupled receptor A1
chr17_+_32444379 0.17 ENST00000578213.5
ENST00000649012.1
ENST00000457654.6
ENST00000579451.1
ENST00000261712.8
proteasome 26S subunit, non-ATPase 11
chr2_-_219308963 0.17 ENST00000423636.6
ENST00000442029.5
ENST00000412847.5
protein tyrosine phosphatase receptor type N
chr9_-_107489754 0.17 ENST00000610832.1
ENST00000374672.5
Kruppel like factor 4
chr5_-_137735997 0.17 ENST00000505853.1
kelch like family member 3
chr1_+_247416166 0.17 ENST00000391827.3
ENST00000336119.8
NLR family pyrin domain containing 3
chr2_+_30146941 0.16 ENST00000379520.7
ENST00000379519.7
yippee like 5
chr6_-_38703066 0.16 ENST00000373365.5
glyoxalase I
chr1_-_23799561 0.16 ENST00000445705.1
UDP-galactose-4-epimerase
chr17_-_28717860 0.16 ENST00000395245.9
RAB34, member RAS oncogene family
chr8_-_17895403 0.16 ENST00000381840.5
ENST00000398054.5
fibrinogen like 1
chr15_-_77071032 0.16 ENST00000559494.1
tetraspanin 3
chr1_+_247416149 0.16 ENST00000366497.6
ENST00000391828.8
NLR family pyrin domain containing 3
chr11_-_707063 0.16 ENST00000683307.1
DEAF1 transcription factor
chr5_-_16916400 0.15 ENST00000513882.5
myosin X
chr18_+_63775395 0.15 ENST00000398019.7
serpin family B member 7
chr15_-_77071099 0.15 ENST00000267970.9
ENST00000346495.6
ENST00000424443.7
ENST00000561277.5
tetraspanin 3
chr2_+_30146993 0.15 ENST00000261353.9
ENST00000402003.7
yippee like 5
chr5_+_66828762 0.15 ENST00000490016.6
ENST00000403666.5
ENST00000450827.5
microtubule associated serine/threonine kinase family member 4
chr11_+_68903849 0.14 ENST00000675615.1
ENST00000255078.8
immunoglobulin mu DNA binding protein 2
chr17_-_28718147 0.14 ENST00000436730.7
ENST00000625712.2
ENST00000450529.5
ENST00000583538.5
ENST00000419712.7
ENST00000580843.6
ENST00000582934.1
ENST00000415040.6
ENST00000353676.9
ENST00000453384.7
RAB34, member RAS oncogene family
chr11_-_11353241 0.14 ENST00000528848.3
casein kinase 2 alpha 3
chr4_+_169660062 0.14 ENST00000507875.5
ENST00000613795.4
chloride voltage-gated channel 3
chr19_-_40414785 0.13 ENST00000674005.2
periaxin
chr17_-_15263162 0.13 ENST00000674673.1
ENST00000675950.1
peripheral myelin protein 22
chr3_-_53844617 0.13 ENST00000481668.5
ENST00000467802.1
choline dehydrogenase
chr5_+_143812161 0.13 ENST00000289448.4
histocompatibility minor HB-1
chr8_-_115492221 0.12 ENST00000518018.1
transcriptional repressor GATA binding 1
chr5_-_141682192 0.12 ENST00000508305.5
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr19_-_18884219 0.12 ENST00000596048.1
ceramide synthase 1
chr11_+_67583803 0.12 ENST00000398606.10
glutathione S-transferase pi 1
chr11_-_2171805 0.11 ENST00000381178.5
ENST00000381175.5
ENST00000333684.9
ENST00000352909.8
tyrosine hydroxylase
chr18_-_268019 0.11 ENST00000631280.2
ENST00000616322.4
ENST00000261600.11
THO complex 1
chr18_-_43115625 0.11 ENST00000590910.1
ENST00000326695.10
ENST00000589109.5
Ras like without CAAX 2
chr3_+_141368497 0.11 ENST00000321464.7
zinc finger and BTB domain containing 38
chr11_-_102955705 0.11 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
matrix metallopeptidase 13
chr5_-_141682211 0.11 ENST00000239440.9
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr4_+_41981745 0.10 ENST00000333141.7
DDB1 and CUL4 associated factor 4 like 1
chrX_-_155264471 0.10 ENST00000369454.4
RAB39B, member RAS oncogene family
chr3_+_113747022 0.10 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATPase H+ transporting V1 subunit A
chr14_+_103334339 0.10 ENST00000558316.5
ENST00000558265.5
eukaryotic translation initiation factor 5
chr14_-_23119248 0.10 ENST00000206513.6
CCAAT enhancer binding protein epsilon
chr2_+_27014746 0.10 ENST00000648289.1
ENST00000458529.5
ENST00000402218.1
microtubule associated protein RP/EB family member 3
chr11_-_75490725 0.10 ENST00000529721.5
glycerophosphodiester phosphodiesterase domain containing 5
chr5_-_43412323 0.10 ENST00000361115.4
C-C motif chemokine ligand 28
chr2_-_237590694 0.10 ENST00000264601.8
ENST00000411462.5
ENST00000409822.1
RAB17, member RAS oncogene family
chr4_-_99657820 0.10 ENST00000511828.2
chromosome 4 open reading frame 54
chr1_-_153057504 0.10 ENST00000392653.3
small proline rich protein 2A
chr11_-_123885627 0.09 ENST00000528595.1
ENST00000375026.7
transmembrane protein 225
chr4_-_7434895 0.09 ENST00000319098.7
prosaposin like 1
chr16_+_31355165 0.09 ENST00000562918.5
ENST00000268296.9
integrin subunit alpha X
chr2_-_11344580 0.09 ENST00000616279.4
ENST00000315872.11
Rho associated coiled-coil containing protein kinase 2
chr12_-_102197827 0.09 ENST00000329406.5
pro-melanin concentrating hormone
chr17_-_29078857 0.09 ENST00000359450.6
TGFB1-induced anti-apoptotic factor 1
chr12_-_54419259 0.09 ENST00000293379.9
integrin subunit alpha 5
chr14_-_94388589 0.09 ENST00000402629.1
ENST00000556091.1
ENST00000393087.9
ENST00000554720.1
serpin family A member 1
chr8_+_98064522 0.09 ENST00000545282.1
glutamate rich 5
chr16_+_31355215 0.09 ENST00000562522.2
integrin subunit alpha X
chr5_+_43602648 0.09 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
nicotinamide nucleotide transhydrogenase
chr6_-_43629222 0.09 ENST00000307126.10
GTP binding protein 2
chr12_+_57455266 0.08 ENST00000266646.3
inhibin subunit beta E
chr2_-_135876382 0.08 ENST00000264156.3
minichromosome maintenance complex component 6
chr19_-_45424364 0.08 ENST00000589165.5
ERCC excision repair 1, endonuclease non-catalytic subunit
chr12_-_8612850 0.08 ENST00000229335.11
ENST00000537228.5
activation induced cytidine deaminase
chr17_+_77450737 0.08 ENST00000541152.6
ENST00000591704.5
septin 9
chr1_-_153094521 0.08 ENST00000368750.8
small proline rich protein 2E
chr20_-_17558811 0.08 ENST00000536626.7
ENST00000377868.6
beaded filament structural protein 1
chr7_+_112423137 0.08 ENST00000005558.8
ENST00000621379.4
interferon related developmental regulator 1
chr19_+_47332167 0.07 ENST00000595464.3
complement component 5a receptor 2
chr22_+_39520553 0.07 ENST00000674920.3
ENST00000679776.1
ENST00000675582.2
ENST00000337304.2
ENST00000676346.2
ENST00000396680.3
ENST00000680446.1
ENST00000674568.2
ENST00000680748.1
ENST00000674835.2
activating transcription factor 4
chr12_+_110281231 0.07 ENST00000539276.7
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.3 1.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 1.2 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 0.7 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 1.2 GO:0071461 cellular response to redox state(GO:0071461)
0.2 0.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.4 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 1.2 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.1 1.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.3 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 0.3 GO:0035732 nitric oxide storage(GO:0035732)
0.1 0.3 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 0.5 GO:1902896 terminal web assembly(GO:1902896)
0.1 1.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.4 GO:0015692 lead ion transport(GO:0015692)
0.1 0.6 GO:0051414 response to cortisol(GO:0051414)
0.1 0.9 GO:0015886 heme transport(GO:0015886)
0.1 0.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.2 GO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.1 0.2 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.2 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
0.1 0.2 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.1 0.4 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.0 0.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0061743 motor learning(GO:0061743)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 1.1 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.3 GO:2000321 interleukin-18 production(GO:0032621) positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.0 1.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0072720 response to dithiothreitol(GO:0072720)
0.0 1.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0018963 phthalate metabolic process(GO:0018963) epinephrine biosynthetic process(GO:0042418) phytoalexin metabolic process(GO:0052314)
0.0 0.1 GO:1902623 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.3 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.1 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.9 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.2 GO:1902748 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.6 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.1 GO:1903347 negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 1.7 GO:0000305 response to oxygen radical(GO:0000305)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.2 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.1 GO:0061394 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
0.0 0.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.4 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.1 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.1 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 1.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.1 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.5 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) post-embryonic hemopoiesis(GO:0035166)
0.0 0.1 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.2 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.0 GO:1902688 regulation of NAD metabolic process(GO:1902688)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.5 GO:0044393 microspike(GO:0044393) cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 1.2 GO:0070652 HAUS complex(GO:0070652)
0.1 0.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 3.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 0.5 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.4 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.4 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 1.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.2 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.5 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.3 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 1.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 0.5 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441)
0.2 0.6 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0035731 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
0.1 1.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.4 GO:1904408 dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
0.1 0.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.3 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 1.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.9 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.4 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.7 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 1.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 0.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 3.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0034617 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) tetrahydrobiopterin binding(GO:0034617)
0.0 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:1990239 estrogen receptor activity(GO:0030284) steroid hormone binding(GO:1990239)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 1.8 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 3.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 0.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins