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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 1.22
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Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000251493.5 | FOXD1 | |
| ENSG00000150907.10 | FOXO1 | |
| ENSG00000204060.7 | FOXO6 | |
| ENSG00000176165.12 | FOXG1 | |
| ENSG00000114861.23 | FOXP1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP1 | hg38_v1_chr3_-_71130892_71130959 | -0.56 | 3.3e-03 | Click! |
| FOXG1 | hg38_v1_chr14_+_28766755_28766802 | -0.47 | 1.9e-02 | Click! |
| FOXO1 | hg38_v1_chr13_-_40666600_40666650 | 0.44 | 3.0e-02 | Click! |
| FOXD1 | hg38_v1_chr5_-_73448769_73448784 | -0.16 | 4.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 2.1 | 14.6 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 12.7 | GO:0010324 | membrane invagination(GO:0010324) |
| 0.1 | 10.2 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 8.9 | GO:1901222 | regulation of NIK/NF-kappaB signaling(GO:1901222) |
| 0.6 | 8.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 1.9 | 7.7 | GO:0042091 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.1 | 7.4 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 1.5 | 7.3 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.0 | 7.0 | GO:0006338 | chromatin remodeling(GO:0006338) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 16.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 15.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.7 | 15.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 8.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 7.2 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 7.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 6.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 5.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 5.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.2 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.9 | 14.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 10.6 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 8.0 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 6.9 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 6.8 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 6.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 6.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 5.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.3 | 5.6 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 20.6 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 9.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 7.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 4.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 3.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 17.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 9.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 7.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 5.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 5.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 4.7 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 4.7 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 4.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 4.4 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |