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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 0.98
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP2 | hg38_v1_chr7_+_114414809_114414822 | 0.56 | 3.3e-03 | Click! |
| FOXK1 | hg38_v1_chr7_+_4682252_4682314 | -0.27 | 1.9e-01 | Click! |
| FOXB1 | hg38_v1_chr15_+_60004305_60004319 | -0.26 | 2.1e-01 | Click! |
| FOXP3 | hg38_v1_chrX_-_49264668_49264800 | 0.21 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 2.2 | 15.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 7.6 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 6.2 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 5.5 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.5 | 5.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 5.4 | GO:0048207 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 4.8 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 1.6 | 4.7 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.1 | 4.7 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 15.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 15.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 9.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.2 | 7.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 5.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 5.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 4.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 4.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 3.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.7 | 14.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 11.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 7.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 5.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 4.9 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.1 | 4.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 4.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 3.9 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.6 | 3.7 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 15.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 14.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 7.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 6.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 3.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 3.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 3.5 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 2.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 18.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 8.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.3 | 5.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 5.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 5.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 5.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 4.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 3.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.6 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |