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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for FOXM1_TBL1XR1
Z-value: 0.98
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBL1XR1 | hg38_v1_chr3_-_177197210_177197233 | 0.26 | 2.2e-01 | Click! |
| FOXM1 | hg38_v1_chr12_-_2877113_2877182, hg38_v1_chr12_-_2876986_2877092 | -0.01 | 9.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_120914549 Show fit | 2.89 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr2_+_102355881 Show fit | 2.32 |
ENST00000409599.5
|
interleukin 18 receptor 1 |
|
| chr2_+_102355750 Show fit | 2.21 |
ENST00000233957.7
|
interleukin 18 receptor 1 |
|
| chr4_-_76023489 Show fit | 2.19 |
ENST00000306602.3
|
C-X-C motif chemokine ligand 10 |
|
| chr1_+_100719734 Show fit | 2.14 |
ENST00000370119.8
ENST00000294728.7 ENST00000347652.6 ENST00000370115.1 |
vascular cell adhesion molecule 1 |
|
| chr2_+_151357583 Show fit | 2.07 |
ENST00000243347.5
|
TNF alpha induced protein 6 |
|
| chr1_-_169734064 Show fit | 2.05 |
ENST00000333360.12
|
selectin E |
|
| chr14_+_22281097 Show fit | 1.92 |
ENST00000390465.2
|
T cell receptor alpha variable 38-2/delta variable 8 |
|
| chr6_+_26383176 Show fit | 1.79 |
ENST00000416795.6
ENST00000494184.1 |
butyrophilin subfamily 2 member A2 |
|
| chr11_-_102780620 Show fit | 1.51 |
ENST00000279441.9
ENST00000539681.1 |
matrix metallopeptidase 10 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.6 | 5.2 | GO:0035655 | interleukin-18-mediated signaling pathway(GO:0035655) |
| 0.1 | 4.9 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.4 | 4.4 | GO:1901740 | negative regulation of myoblast fusion(GO:1901740) |
| 0.2 | 3.9 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 3.1 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.2 | 3.0 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.2 | 2.8 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.3 | 2.4 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.4 | 2.3 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.3 | 2.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.3 | 2.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 2.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.7 | 2.1 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.2 | 2.0 | GO:0097486 | multivesicular body lumen(GO:0097486) |
| 0.2 | 1.9 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 1.9 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.2 | 1.7 | GO:0036021 | endolysosome lumen(GO:0036021) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.6 | 4.8 | GO:0042008 | interleukin-18 receptor activity(GO:0042008) |
| 0.3 | 4.6 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 4.2 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 4.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.2 | 3.7 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.1 | 3.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.6 | 3.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 3.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 2.9 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 6.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 5.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 5.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 2.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 5.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 5.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 4.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 3.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 3.4 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 3.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 2.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 2.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |