Project

Inflammatory response time course, HUVEC (Wada, 2009)

Navigation
Downloads

Results for FOXN1

Z-value: 0.67

Motif logo

Transcription factors associated with FOXN1

Gene Symbol Gene ID Gene Info
ENSG00000109101.8 FOXN1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXN1hg38_v1_chr17_+_28506320_285063600.067.9e-01Click!

Activity profile of FOXN1 motif

Sorted Z-values of FOXN1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXN1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image
Promoter Score Transcript Gene Gene Info
chr1_+_81800368 2.16 ENST00000674489.1
ENST00000674442.1
ENST00000674419.1
ENST00000674407.1
ENST00000674168.1
ENST00000674307.1
ENST00000674209.1
ENST00000370715.5
ENST00000370713.5
ENST00000319517.10
ENST00000627151.2
ENST00000370717.6
adhesion G protein-coupled receptor L2
chr8_-_92103217 1.87 ENST00000615601.4
ENST00000523629.5
RUNX1 partner transcriptional co-repressor 1
chr2_-_156342348 1.85 ENST00000409572.5
nuclear receptor subfamily 4 group A member 2
chr7_-_120858066 1.84 ENST00000222747.8
tetraspanin 12
chr7_+_90211686 1.81 ENST00000287908.7
ENST00000394621.7
ENST00000394626.5
STEAP2 metalloreductase
chr20_+_31605280 1.75 ENST00000376105.4
ENST00000376112.4
inhibitor of DNA binding 1, HLH protein
chr1_+_25616780 1.75 ENST00000374332.9
mannosidase alpha class 1C member 1
chr7_+_90211830 1.70 ENST00000394622.6
ENST00000394632.5
ENST00000426158.1
ENST00000402625.6
STEAP2 metalloreductase
chr15_-_70892412 1.63 ENST00000249861.9
THAP domain containing 10
chr17_+_42761246 1.60 ENST00000587142.5
ENST00000588576.1
receptor activity modifying protein 2
chr18_+_23135452 1.58 ENST00000580153.5
ENST00000256925.12
Cdk5 and Abl enzyme substrate 1
chr17_+_42761218 1.47 ENST00000253796.10
receptor activity modifying protein 2
chr13_-_109786567 1.37 ENST00000375856.5
insulin receptor substrate 2
chr14_+_61321571 1.31 ENST00000332981.11
protein kinase C eta
chr17_+_42760747 1.29 ENST00000589683.5
receptor activity modifying protein 2
chr17_+_42760805 1.25 ENST00000588928.1
receptor activity modifying protein 2
chr5_-_100903252 1.22 ENST00000231461.10
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr20_-_37527723 1.21 ENST00000397135.1
ENST00000397137.5
BLCAP apoptosis inducing factor
chrX_-_117973717 1.13 ENST00000262820.7
kelch like family member 13
chr2_+_112645930 1.06 ENST00000272542.8
solute carrier family 20 member 1
chrX_-_117973579 1.04 ENST00000371878.5
kelch like family member 13
chr4_-_101346842 1.00 ENST00000507176.5
protein phosphatase 3 catalytic subunit alpha
chr7_-_120858303 0.97 ENST00000415871.5
ENST00000430985.1
tetraspanin 12
chr12_+_12785652 0.95 ENST00000356591.5
apolipoprotein L domain containing 1
chr12_+_32107151 0.93 ENST00000548411.5
BICD cargo adaptor 1
chr6_-_2245563 0.91 ENST00000380815.5
GDP-mannose 4,6-dehydratase
chr14_-_77028663 0.87 ENST00000238647.5
interferon regulatory factor 2 binding protein like
chr8_+_142727186 0.86 ENST00000336138.4
thioesterase superfamily member 6
chr20_+_59940362 0.86 ENST00000360816.8
family with sequence similarity 217 member B
chr5_+_94618653 0.81 ENST00000265140.10
ENST00000504099.5
SMC5-SMC6 complex localization factor 1
chr3_+_52246204 0.80 ENST00000409502.7
protein phosphatase, Mg2+/Mn2+ dependent 1M
chr15_-_55408245 0.76 ENST00000563171.5
ENST00000425574.7
ENST00000442196.8
ENST00000564092.1
cell cycle progression 1
chr10_-_50623897 0.76 ENST00000361781.7
ENST00000429490.5
ENST00000619438.4
sphingomyelin synthase 1
chr7_-_132576493 0.76 ENST00000321063.8
plexin A4
chr15_+_40929338 0.75 ENST00000249749.7
delta like canonical Notch ligand 4
chr3_+_52245721 0.74 ENST00000323588.9
protein phosphatase, Mg2+/Mn2+ dependent 1M
chr7_-_132577301 0.74 ENST00000359827.7
plexin A4
chr1_-_58546693 0.73 ENST00000456980.5
ENST00000482274.2
ENST00000453710.1
ENST00000371226.8
ENST00000419242.5
ENST00000426139.5
OMA1 zinc metallopeptidase
chr10_+_127907036 0.73 ENST00000254667.8
ENST00000442830.5
protein tyrosine phosphatase receptor type E
chr20_-_37527891 0.72 ENST00000414542.6
BLCAP apoptosis inducing factor
chr17_+_38352021 0.72 ENST00000665913.1
ENST00000613678.5
suppressor of cytokine signaling 7
chr12_+_43836043 0.71 ENST00000266534.8
ENST00000551577.5
transmembrane protein 117
chr11_-_83071819 0.70 ENST00000524635.1
ENST00000526205.5
ENST00000533486.5
ENST00000533276.6
ENST00000527633.6
RAB30, member RAS oncogene family
chr17_-_66192125 0.69 ENST00000535342.7
centrosomal protein 112
chr3_+_52246158 0.68 ENST00000296487.8
protein phosphatase, Mg2+/Mn2+ dependent 1M
chr19_+_1249870 0.67 ENST00000591446.6
midnolin
chr17_-_66191855 0.67 ENST00000583358.1
ENST00000392769.6
centrosomal protein 112
chr15_-_55408018 0.65 ENST00000569205.5
cell cycle progression 1
chr15_-_55408467 0.60 ENST00000310958.10
cell cycle progression 1
chr15_+_55408479 0.60 ENST00000569691.2
chromosome 15 open reading frame 65
chr20_-_37527862 0.59 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP apoptosis inducing factor
chr20_+_325536 0.58 ENST00000342665.5
SRY-box transcription factor 12
chrX_+_153972729 0.58 ENST00000369982.5
transmembrane protein 187
chr18_-_55588535 0.57 ENST00000566286.5
ENST00000566279.5
ENST00000626595.2
ENST00000564999.5
ENST00000616053.4
ENST00000356073.8
transcription factor 4
chr8_-_11201339 0.57 ENST00000297303.4
XK related 6
chr2_-_38602888 0.56 ENST00000449105.8
ENST00000410076.5
heterogeneous nuclear ribonucleoprotein L like
chr17_-_78925376 0.55 ENST00000262768.11
TIMP metallopeptidase inhibitor 2
chrX_-_107716401 0.54 ENST00000486554.1
ENST00000372390.8
TSC22 domain family member 3
chr17_+_38351832 0.53 ENST00000612932.6
suppressor of cytokine signaling 7
chr15_-_52179881 0.52 ENST00000396335.8
ENST00000560116.1
ENST00000358784.11
G protein subunit beta 5
chr4_-_169612571 0.52 ENST00000507142.6
ENST00000510533.5
ENST00000439128.6
ENST00000511633.5
ENST00000512193.5
NIMA related kinase 1
chr19_-_14529193 0.52 ENST00000596853.6
ENST00000676515.1
ENST00000678338.1
ENST00000595992.6
ENST00000677848.1
ENST00000677762.1
ENST00000678009.1
ENST00000596075.2
ENST00000601533.6
ENST00000396969.8
ENST00000598692.2
ENST00000678098.1
DnaJ heat shock protein family (Hsp40) member B1
chr12_+_51238854 0.52 ENST00000549732.6
ENST00000604900.5
DAZ associated protein 2
chr6_-_36839434 0.52 ENST00000244751.7
ENST00000633280.1
copine 5
chr1_+_220786853 0.50 ENST00000366910.10
mitochondrial amidoxime reducing component 1
chr1_+_65792889 0.49 ENST00000341517.9
phosphodiesterase 4B
chr10_-_102419934 0.48 ENST00000406432.5
pleckstrin and Sec7 domain containing
chr17_-_7484205 0.47 ENST00000311403.4
zinc finger and BTB domain containing 4
chr2_-_73293538 0.46 ENST00000436467.4
ENST00000545030.1
early growth response 4
chr17_+_7834200 0.45 ENST00000448097.7
lysine demethylase 6B
chr5_+_100535317 0.45 ENST00000312637.5
family with sequence similarity 174 member A
chr12_+_32106762 0.45 ENST00000551848.1
ENST00000652176.1
BICD cargo adaptor 1
chr5_-_94111627 0.43 ENST00000505869.5
ENST00000395965.8
ENST00000509163.5
family with sequence similarity 172 member A
chrX_+_52184904 0.42 ENST00000375626.7
ENST00000467526.1
MAGE family member D4
chr12_-_101830671 0.42 ENST00000549165.1
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
chr18_-_55588184 0.42 ENST00000354452.8
ENST00000565908.6
ENST00000635822.2
transcription factor 4
chr19_-_37172670 0.42 ENST00000588354.1
ENST00000292841.10
ENST00000356958.8
zinc finger protein 585A
chr1_-_113759099 0.42 ENST00000393357.6
ENST00000446739.1
putative homeodomain transcription factor 1
chr2_-_128028114 0.41 ENST00000259234.10
Sin3A associated protein 130
chr19_+_38264563 0.40 ENST00000301244.12
ENST00000587090.5
ENST00000454580.7
serine peptidase inhibitor, Kunitz type 2
chr19_-_42302576 0.40 ENST00000262890.8
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr2_-_128028010 0.40 ENST00000643581.2
ENST00000450957.1
Sin3A associated protein 130
chr1_-_113759338 0.40 ENST00000369598.5
ENST00000369600.5
putative homeodomain transcription factor 1
chr15_+_49155750 0.40 ENST00000327171.7
ENST00000560654.5
galactokinase 2
chrX_-_100636799 0.40 ENST00000373020.9
tetraspanin 6
chr5_+_111224374 0.39 ENST00000282356.9
calcium/calmodulin dependent protein kinase IV
chr19_-_42302690 0.39 ENST00000596265.5
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr6_+_7590179 0.38 ENST00000342415.6
small nuclear ribonucleoprotein U11/U12 subunit 48
chr1_-_143971965 0.38 ENST00000369175.4
ENST00000584486.6
family with sequence similarity 72 member C
chr17_-_48101379 0.38 ENST00000581003.5
ENST00000225603.9
chromobox 1
chr17_-_48101087 0.37 ENST00000393408.7
chromobox 1
chr10_+_102420823 0.37 ENST00000369956.8
ENST00000425536.1
F-box and leucine rich repeat protein 15
chr1_+_74198230 0.37 ENST00000557284.7
ENST00000370899.7
ENST00000370895.5
ENST00000534632.5
ENST00000370893.1
ENST00000467578.7
ENST00000370894.9
ENST00000482102.2
ENST00000370898.9
ENST00000534056.5
FPGT-TNNI3K readthrough
fucose-1-phosphate guanylyltransferase
chr8_+_406941 0.37 ENST00000382824.5
ENST00000350302.8
F-box protein 25
chr20_+_64038120 0.36 ENST00000463337.1
chromosome 20 open reading frame 204
chr19_-_48364034 0.36 ENST00000435956.7
transmembrane protein 143
chr7_+_139231225 0.36 ENST00000473989.8
ubinuclein 2
chr1_-_113759464 0.36 ENST00000357783.6
ENST00000369604.6
putative homeodomain transcription factor 1
chr4_-_53591477 0.36 ENST00000263925.8
ligand of numb-protein X 1
chr19_-_19033480 0.36 ENST00000452918.7
ENST00000600377.1
ENST00000337018.10
SURP and G-patch domain containing 2
chr3_-_86991135 0.36 ENST00000398399.7
vestigial like family member 3
chr2_+_53971072 0.35 ENST00000422521.2
ENST00000607452.6
acylphosphatase 2
chr19_-_37172432 0.35 ENST00000392157.2
zinc finger protein 585A
chr18_+_21242254 0.34 ENST00000269218.10
GREB1 like retinoic acid receptor coactivator
chr11_-_74170975 0.34 ENST00000539061.6
ENST00000680645.1
ENST00000334126.12
ENST00000680718.1
C2 domain containing 3 centriole elongation regulator
chr6_-_109094819 0.34 ENST00000436639.6
sestrin 1
chr5_+_154858594 0.34 ENST00000519430.5
ENST00000520671.5
ENST00000521583.5
ENST00000285896.11
ENST00000518028.5
ENST00000519404.5
ENST00000519394.5
ENST00000518775.5
CCR4-NOT transcription complex subunit 8
chr10_+_14838288 0.33 ENST00000640019.3
ENST00000493178.1
ENST00000378372.8
novel protein
heat shock protein family A (Hsp70) member 14
chr1_-_77683356 0.33 ENST00000414381.5
ENST00000370798.5
zinc finger ZZ-type containing 3
chr7_+_97117676 0.33 ENST00000432641.3
succinate dehydrogenase complex assembly factor 3
chr19_-_42302766 0.33 ENST00000595530.5
ENST00000538771.5
ENST00000601865.5
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr5_+_123512214 0.33 ENST00000511130.6
ENST00000512718.7
casein kinase 1 gamma 3
chr1_+_145095967 0.33 ENST00000400889.3
family with sequence similarity 72 member D
chr13_-_46052712 0.33 ENST00000242848.8
ENST00000679008.1
ENST00000282007.7
zinc finger CCCH-type containing 13
chr6_+_53065385 0.33 ENST00000323557.12
F-box protein 9
chr2_+_27890716 0.32 ENST00000344773.6
ENST00000379624.6
ENST00000342045.6
ENST00000379632.6
ENST00000361704.6
BRISC and BRCA1 A complex member 2
chr4_+_153152163 0.32 ENST00000676423.1
ENST00000675745.1
ENST00000676348.1
ENST00000676408.1
ENST00000674874.1
ENST00000675315.1
ENST00000675518.1
tripartite motif containing 2
novel protein
chr19_+_12791470 0.32 ENST00000302754.6
JunB proto-oncogene, AP-1 transcription factor subunit
chr8_-_38269116 0.32 ENST00000529359.5
phospholipid phosphatase 5
chr10_+_101354083 0.32 ENST00000408038.6
ENST00000370187.8
beta-transducin repeat containing E3 ubiquitin protein ligase
chr5_+_154858218 0.32 ENST00000523698.5
ENST00000517876.5
ENST00000520472.5
CCR4-NOT transcription complex subunit 8
chr5_-_132556809 0.32 ENST00000450655.1
interleukin 5
chr10_-_14838561 0.32 ENST00000378442.5
cerebral dopamine neurotrophic factor
chr10_-_27240850 0.31 ENST00000426079.5
ENST00000677248.1
ENST00000375897.7
acyl-CoA binding domain containing 5
chr19_-_48363914 0.31 ENST00000377431.6
ENST00000293261.8
transmembrane protein 143
chr12_+_57550027 0.31 ENST00000674619.1
ENST00000676359.1
ENST00000286452.5
ENST00000455537.7
ENST00000676457.1
kinesin family member 5A
chr11_-_83071917 0.31 ENST00000534141.5
RAB30, member RAS oncogene family
chr11_-_27363190 0.31 ENST00000328697.11
ENST00000317945.6
coiled-coil domain containing 34
chr5_+_172834225 0.31 ENST00000393784.8
endoplasmic reticulum-golgi intermediate compartment 1
chr10_+_18340699 0.30 ENST00000377329.10
calcium voltage-gated channel auxiliary subunit beta 2
chr10_-_121975168 0.30 ENST00000369017.5
ENST00000369023.8
NSE4 homolog A, SMC5-SMC6 complex component
chr3_-_38649668 0.30 ENST00000333535.9
ENST00000413689.6
ENST00000423572.7
sodium voltage-gated channel alpha subunit 5
chr7_+_97117718 0.30 ENST00000360382.4
succinate dehydrogenase complex assembly factor 3
chr17_-_38799442 0.30 ENST00000619039.5
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
chr7_-_92528446 0.29 ENST00000248633.9
peroxisomal biogenesis factor 1
chr5_+_154858482 0.29 ENST00000519211.5
ENST00000522458.5
ENST00000519903.5
ENST00000521450.5
ENST00000403027.6
CCR4-NOT transcription complex subunit 8
chr20_-_32584795 0.29 ENST00000201961.6
ENST00000621426.6
nucleolar protein 4 like
chr14_-_92121669 0.29 ENST00000605997.6
ENST00000553514.5
ENST00000617122.1
NADH:ubiquinone oxidoreductase subunit B1
chr5_+_132556911 0.28 ENST00000651541.1
ENST00000378823.8
ENST00000652485.1
RAD50 double strand break repair protein
chr3_-_139539577 0.28 ENST00000619087.4
retinol binding protein 1
chr5_-_154038866 0.28 ENST00000522858.5
ENST00000522634.1
ENST00000523705.5
ENST00000524246.1
ENST00000520313.5
ENST00000351797.9
ENST00000518102.5
ENST00000520667.5
ENST00000519808.5
ENST00000522395.5
family with sequence similarity 114 member A2
chr9_+_129036614 0.28 ENST00000684074.1
mitoguardin 2
chr11_-_74170792 0.27 ENST00000680231.1
ENST00000681143.1
ENST00000679906.1
ENST00000681310.1
ENST00000414160.7
ENST00000538361.2
C2 domain containing 3 centriole elongation regulator
chr14_-_92121902 0.27 ENST00000329559.8
NADH:ubiquinone oxidoreductase subunit B1
chr9_+_111631354 0.26 ENST00000374294.3
DNAJC25-GNG10 readthrough
chr12_+_120496101 0.26 ENST00000550178.1
ENST00000550845.5
ENST00000549989.1
ENST00000552870.1
ENST00000242577.11
dynein light chain LC8-type 1
chr7_-_92528433 0.26 ENST00000428214.5
ENST00000438045.5
peroxisomal biogenesis factor 1
chr17_+_63998344 0.26 ENST00000577953.5
ENST00000582540.5
ENST00000579184.5
ENST00000425164.7
ENST00000412177.6
ENST00000583891.5
ENST00000580752.1
proline rich 29
chr12_-_80937918 0.26 ENST00000552864.6
lin-7 homolog A, crumbs cell polarity complex component
chr2_-_68467272 0.26 ENST00000377957.4
F-box protein 48
chr22_-_20437785 0.26 ENST00000622235.5
ENST00000623402.1
scavenger receptor class F member 2
chr18_-_47150448 0.25 ENST00000590815.5
ENST00000587388.5
ENST00000590481.5
ENST00000591480.5
ENST00000592591.1
ENST00000300605.11
haloacid dehalogenase like hydrolase domain containing 2
chr12_-_51270175 0.25 ENST00000604188.1
ENST00000398453.7
small cell adhesion glycoprotein
chr7_-_130668705 0.25 ENST00000330992.8
ENST00000425248.5
COPI coat complex subunit gamma 2
chr10_+_101354028 0.25 ENST00000393441.8
beta-transducin repeat containing E3 ubiquitin protein ligase
chr1_-_9071716 0.25 ENST00000484798.5
solute carrier family 2 member 5
chr13_-_46387447 0.25 ENST00000676051.1
ENST00000378787.7
ENST00000378781.7
ENST00000378797.6
rubicon like autophagy enhancer
chr12_+_49346911 0.24 ENST00000395069.3
DnaJ heat shock protein family (Hsp40) member C22
chr1_-_234610169 0.24 ENST00000366609.4
interferon regulatory factor 2 binding protein 2
chr1_+_11934651 0.24 ENST00000449038.5
ENST00000196061.5
ENST00000429000.6
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
chrX_-_84188148 0.24 ENST00000262752.5
ribosomal protein S6 kinase A6
chr7_+_131327863 0.24 ENST00000352689.11
muskelin 1
chr7_-_132576463 0.24 ENST00000423507.6
plexin A4
chr12_+_56080126 0.24 ENST00000411731.6
erb-b2 receptor tyrosine kinase 3
chr3_-_195442977 0.24 ENST00000326793.11
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr12_-_51269949 0.24 ENST00000603864.5
ENST00000605426.5
small cell adhesion glycoprotein
chr3_+_46979659 0.24 ENST00000450053.8
neurobeachin like 2
chr3_+_138347648 0.23 ENST00000614350.4
ENST00000289104.8
muscle RAS oncogene homolog
chr19_+_42268505 0.23 ENST00000572681.6
capicua transcriptional repressor
chr8_+_406808 0.22 ENST00000352684.2
F-box protein 25
chr8_-_11201799 0.22 ENST00000416569.3
XK related 6
chrX_+_131058340 0.22 ENST00000276211.10
ENST00000370922.5
Rho GTPase activating protein 36
chr9_+_129835442 0.22 ENST00000372429.8
ENST00000315480.9
ENST00000358355.5
ubiquitin specific peptidase 20
chr8_+_38386303 0.22 ENST00000519476.6
leucine zipper and EF-hand containing transmembrane protein 2
chr10_+_70404129 0.22 ENST00000373218.5
eukaryotic translation initiation factor 4E binding protein 2
chr12_+_120496075 0.22 ENST00000548214.1
ENST00000392508.2
dynein light chain LC8-type 1
chr5_+_32710630 0.22 ENST00000326958.5
natriuretic peptide receptor 3
chr2_-_20051610 0.21 ENST00000175091.5
lysosomal protein transmembrane 4 alpha
chr2_-_38602626 0.21 ENST00000378915.7
heterogeneous nuclear ribonucleoprotein L like
chr1_+_22451843 0.21 ENST00000375647.5
ENST00000404138.5
ENST00000374651.8
ENST00000400239.6
zinc finger and BTB domain containing 40
chr14_+_54396964 0.21 ENST00000543789.6
ENST00000442975.6
ENST00000458126.6
ENST00000556102.6
ENST00000335183.11
cyclin dependent kinase inhibitor 3
chr14_+_54397021 0.21 ENST00000541304.5
cyclin dependent kinase inhibitor 3
chr5_+_132658165 0.21 ENST00000617259.2
ENST00000304506.7
interleukin 13
chr8_+_38386433 0.20 ENST00000297720.9
ENST00000524874.5
ENST00000379957.9
ENST00000523983.6
leucine zipper and EF-hand containing transmembrane protein 2
chr10_-_27240505 0.20 ENST00000375888.5
ENST00000676732.1
acyl-CoA binding domain containing 5
chr13_-_46387724 0.20 ENST00000675585.1
rubicon like autophagy enhancer
chr14_+_54396949 0.20 ENST00000611205.4
cyclin dependent kinase inhibitor 3
chr6_+_34466059 0.20 ENST00000620693.4
ENST00000244458.7
ENST00000374043.6
protein kinase C and casein kinase substrate in neurons 1
chr5_+_69093980 0.20 ENST00000380860.8
ENST00000396591.8
ENST00000504103.5
ENST00000502979.1
solute carrier family 30 member 5
chr2_-_27890348 0.20 ENST00000302188.8
ribokinase
chr3_+_149813049 0.20 ENST00000466478.5
ENST00000491086.5
ENST00000467977.5
ENST00000392894.8
ring finger protein 13
chr19_+_1266653 0.20 ENST00000586472.5
ENST00000589266.5
cold inducible RNA binding protein
chr2_-_100417608 0.19 ENST00000264249.8
carbohydrate sulfotransferase 10
chr10_+_18340821 0.19 ENST00000612743.1
ENST00000612134.4
calcium voltage-gated channel auxiliary subunit beta 2
chr10_-_27240743 0.19 ENST00000677901.1
ENST00000677960.1
ENST00000677440.1
ENST00000396271.8
ENST00000677141.1
ENST00000677311.1
ENST00000677667.1
ENST00000677200.1
ENST00000676997.1
ENST00000676511.1
acyl-CoA binding domain containing 5
chr3_-_133661896 0.19 ENST00000260810.10
DNA topoisomerase II binding protein 1
chr13_-_46387151 0.19 ENST00000676114.1
rubicon like autophagy enhancer
chr11_-_117232033 0.19 ENST00000524507.6
ENST00000320934.8
ENST00000532301.5
ENST00000676339.1
ENST00000540028.5
proprotein convertase subtilisin/kexin type 7
chr16_+_2471284 0.19 ENST00000293973.2
netrin 3
chr8_-_99893622 0.18 ENST00000520271.5
ENST00000522940.5
ENST00000523016.1
ENST00000517682.6
ENST00000297564.6
cytochrome c oxidase subunit 6C

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.6 1.7 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.6 5.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 3.5 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.4 1.7 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.4 1.8 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.3 1.0 GO:1900276 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.3 1.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.2 1.4 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.2 0.9 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.2 0.8 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) protein localization to site of double-strand break(GO:1990166)
0.2 0.6 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 1.8 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 0.6 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.1 0.7 GO:1903588 regulation of neural retina development(GO:0061074) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 1.3 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.3 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.3 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 0.4 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.7 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.5 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 1.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 0.3 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.7 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.5 GO:0021997 neural plate axis specification(GO:0021997)
0.1 0.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.7 GO:0030242 pexophagy(GO:0030242)
0.1 0.9 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.2 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 2.8 GO:0010842 retina layer formation(GO:0010842)
0.1 1.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.2 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.5 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.2 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.3 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 0.6 GO:2000580 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.2 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 2.5 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.5 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 0.3 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.1 GO:0030221 basophil differentiation(GO:0030221)
0.0 0.2 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.2 GO:1990539 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.3 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.3 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.9 GO:0042118 endothelial cell activation(GO:0042118)
0.0 1.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.4 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 1.4 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.4 GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532)
0.0 0.3 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.6 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.5 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.4 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.1 GO:0071603 desmosome assembly(GO:0002159) endothelial cell-cell adhesion(GO:0071603)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0021747 cochlear nucleus development(GO:0021747)
0.0 0.4 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.8 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.0 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.0 0.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.0 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.0 0.0 GO:0031393 negative regulation of prostaglandin biosynthetic process(GO:0031393)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.0 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.6 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.3 1.0 GO:0072517 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.1 1.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 6.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.8 GO:0001940 male pronucleus(GO:0001940)
0.1 1.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.8 GO:0042405 nucleosome(GO:0000786) nuclear inclusion body(GO:0042405)
0.0 0.9 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 1.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.6 GO:0097643 amylin receptor activity(GO:0097643)
0.6 3.5 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.5 2.2 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.2 1.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.2 2.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 1.3 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 1.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.2 1.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 0.8 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.0 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 1.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.4 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.1 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 2.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 1.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 1.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.4 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.3 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1 1.5 GO:0070628 proteasome binding(GO:0070628)
0.1 0.3 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.1 0.3 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.7 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.0 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.0 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.8 PID ALK1 PATHWAY ALK1 signaling events
0.0 2.0 PID AURORA B PATHWAY Aurora B signaling
0.0 1.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 2.2 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 6.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 1.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production