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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for GATA3
Z-value: 1.63
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg38_v1_chr10_+_8054808_8054824 | -0.76 | 1.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_48652493 Show fit | 4.67 |
ENST00000435790.6
|
Rho GTPase activating protein 22 |
|
| chr2_+_227813834 Show fit | 4.65 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
|
| chr2_-_224982420 Show fit | 4.50 |
ENST00000645028.1
|
dedicator of cytokinesis 10 |
|
| chr4_+_73740541 Show fit | 4.12 |
ENST00000401931.1
ENST00000307407.8 |
C-X-C motif chemokine ligand 8 |
|
| chr5_-_147401591 Show fit | 4.03 |
ENST00000520473.1
|
dihydropyrimidinase like 3 |
|
| chr6_+_32844789 Show fit | 3.93 |
ENST00000414474.5
|
proteasome 20S subunit beta 9 |
|
| chr5_+_132073782 Show fit | 3.43 |
ENST00000296871.4
|
colony stimulating factor 2 |
|
| chr3_-_127822455 Show fit | 3.26 |
ENST00000265052.10
|
monoglyceride lipase |
|
| chr15_+_67125707 Show fit | 3.26 |
ENST00000540846.6
|
SMAD family member 3 |
|
| chr7_-_93148345 Show fit | 3.22 |
ENST00000437805.5
ENST00000446959.5 ENST00000439952.5 ENST00000414791.5 ENST00000446033.1 ENST00000411955.5 ENST00000318238.9 |
sterile alpha motif domain containing 9 like |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.4 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.6 | 7.8 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.3 | 7.6 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.6 | 6.9 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.4 | 6.7 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.5 | 5.7 | GO:2000535 | regulation of entry of bacterium into host cell(GO:2000535) |
| 1.8 | 5.3 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.1 | 5.2 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.4 | 5.1 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.1 | 5.1 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 8.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 8.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.8 | 7.6 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.7 | 7.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.3 | 6.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 6.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 5.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 5.7 | GO:0035770 | ribonucleoprotein granule(GO:0035770) |
| 0.1 | 5.0 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 10.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 8.8 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 8.7 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.2 | 8.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.3 | 7.6 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.4 | 6.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 5.8 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 5.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 5.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 19.1 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.2 | 17.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 13.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 9.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 7.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.2 | 4.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 4.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 4.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 17.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 8.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 8.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 7.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 7.1 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.3 | 7.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 6.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 6.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |