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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for GATA6

Z-value: 0.29

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.11 GATA6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg38_v1_chr18_+_22169580_22169596-0.262.1e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_92095215 0.63 ENST00000360348.6
ENST00000520428.5
ENST00000518992.5
ENST00000520556.5
ENST00000518317.5
ENST00000521319.5
ENST00000521375.5
ENST00000518449.5
ENST00000613886.4
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr4_-_185775890 0.61 ENST00000437304.6
SORBS2
sorbin and SH3 domain containing 2
chr22_-_19881369 0.37 ENST00000462330.5
TXNRD2
thioredoxin reductase 2
chr22_-_19881163 0.37 ENST00000485358.5
TXNRD2
thioredoxin reductase 2
chr7_+_155298561 0.28 ENST00000476756.1
INSIG1
insulin induced gene 1
chr20_+_45306834 0.28 ENST00000343694.8
ENST00000372741.7
ENST00000372743.5
RBPJL
recombination signal binding protein for immunoglobulin kappa J region like
chr17_-_49764123 0.28 ENST00000240364.7
ENST00000506156.1
FAM117A
family with sequence similarity 117 member A
chr1_+_25272479 0.27 ENST00000622561.4
RHD
Rh blood group D antigen
chr8_+_69492793 0.26 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
SULF1
sulfatase 1
chr1_+_25272502 0.25 ENST00000328664.9
RHD
Rh blood group D antigen
chr2_+_172928165 0.24 ENST00000535187.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr22_+_35066136 0.22 ENST00000308700.6
ENST00000404699.7
ISX
intestine specific homeobox
chr1_-_225999312 0.22 ENST00000272091.8
SDE2
SDE2 telomere maintenance homolog
chr12_+_109347903 0.22 ENST00000310903.9
MYO1H
myosin IH
chr9_-_112175185 0.21 ENST00000355396.7
SUSD1
sushi domain containing 1
chr17_-_64006880 0.21 ENST00000449662.6
ICAM2
intercellular adhesion molecule 2
chr9_-_112175264 0.20 ENST00000374264.6
SUSD1
sushi domain containing 1
chr2_+_137964446 0.20 ENST00000280096.5
ENST00000280097.5
HNMT
histamine N-methyltransferase
chr2_-_43838832 0.20 ENST00000405322.8
ABCG5
ATP binding cassette subfamily G member 5
chr21_-_38498415 0.19 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG
chr16_+_283157 0.18 ENST00000219406.11
ENST00000404312.5
ENST00000456379.1
PDIA2
protein disulfide isomerase family A member 2
chr2_+_108621260 0.17 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr13_-_40982880 0.17 ENST00000635415.1
ELF1
E74 like ETS transcription factor 1
chr9_-_112175283 0.17 ENST00000374270.8
ENST00000374263.7
SUSD1
sushi domain containing 1
chr12_-_6124662 0.16 ENST00000261405.10
VWF
von Willebrand factor
chr14_-_22815856 0.15 ENST00000554758.1
ENST00000397528.8
SLC7A7
solute carrier family 7 member 7
chr1_-_93585071 0.15 ENST00000539242.5
BCAR3
BCAR3 adaptor protein, NSP family member
chr1_+_66534171 0.14 ENST00000682762.1
ENST00000424320.6
SGIP1
SH3GL interacting endocytic adaptor 1
chr1_+_25272527 0.14 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
RHD
Rh blood group D antigen
chr19_-_13102848 0.14 ENST00000264824.5
LYL1
LYL1 basic helix-loop-helix family member
chr14_-_22815801 0.14 ENST00000397532.9
SLC7A7
solute carrier family 7 member 7
chr8_+_69466617 0.14 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
SULF1
sulfatase 1
chr14_-_22815421 0.13 ENST00000674313.1
ENST00000555959.1
SLC7A7
solute carrier family 7 member 7
chr3_+_148865288 0.13 ENST00000296046.4
CPA3
carboxypeptidase A3
chr1_-_158686700 0.12 ENST00000643759.2
SPTA1
spectrin alpha, erythrocytic 1
chr2_+_102311546 0.12 ENST00000233954.6
ENST00000447231.5
IL1RL1
interleukin 1 receptor like 1
chr14_+_75522427 0.10 ENST00000286639.8
BATF
basic leucine zipper ATF-like transcription factor
chr11_+_10305065 0.10 ENST00000534464.1
ENST00000278175.10
ENST00000530439.1
ENST00000524948.5
ENST00000528655.5
ENST00000526492.4
ENST00000525063.2
ADM
adrenomedullin
chr12_-_122395422 0.10 ENST00000540304.6
CLIP1
CAP-Gly domain containing linker protein 1
chr1_+_154321107 0.09 ENST00000484864.1
AQP10
aquaporin 10
chr1_+_154321076 0.09 ENST00000324978.8
AQP10
aquaporin 10
chr19_-_38812936 0.09 ENST00000307751.9
ENST00000594209.1
LGALS4
galectin 4
chrX_-_10833643 0.09 ENST00000380785.5
ENST00000380787.5
MID1
midline 1
chr12_+_71938837 0.09 ENST00000333850.4
TPH2
tryptophan hydroxylase 2
chr11_-_116837586 0.09 ENST00000375320.5
ENST00000359492.6
ENST00000375329.6
ENST00000375323.5
ENST00000236850.5
APOA1
apolipoprotein A1
chr11_-_47352693 0.09 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
MYBPC3
myosin binding protein C3
chr1_-_24143112 0.08 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr11_+_119087979 0.08 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
HMBS
hydroxymethylbilane synthase
chr1_+_161166390 0.08 ENST00000352210.9
ENST00000367999.9
ENST00000497522.5
ENST00000652182.1
ENST00000544598.5
ENST00000535223.5
PPOX
protoporphyrinogen oxidase
chr6_-_30161200 0.08 ENST00000449742.7
TRIM10
tripartite motif containing 10
chr1_+_25272492 0.07 ENST00000454452.6
RHD
Rh blood group D antigen
chr15_-_43220989 0.07 ENST00000540029.5
ENST00000441366.7
ENST00000648595.1
EPB42
erythrocyte membrane protein band 4.2
chr7_-_100641507 0.07 ENST00000431692.5
ENST00000223051.8
TFR2
transferrin receptor 2
chr14_+_52707178 0.07 ENST00000612399.4
PSMC6
proteasome 26S subunit, ATPase 6
chr14_+_52707192 0.07 ENST00000445930.7
ENST00000555339.5
ENST00000556813.1
PSMC6
proteasome 26S subunit, ATPase 6
chr6_+_130018565 0.07 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr2_-_43676406 0.06 ENST00000475092.4
C1GALT1C1L
C1GALT1 specific chaperone 1 like
chr11_-_59845496 0.06 ENST00000257248.3
CBLIF
cobalamin binding intrinsic factor
chr3_+_152268920 0.06 ENST00000495875.6
ENST00000324210.10
ENST00000493459.5
MBNL1
muscleblind like splicing regulator 1
chr17_-_40782544 0.06 ENST00000301656.4
KRT27
keratin 27
chr8_+_21966215 0.06 ENST00000433566.8
XPO7
exportin 7
chr7_+_128739395 0.06 ENST00000479257.5
CALU
calumenin
chr19_-_55038256 0.05 ENST00000417454.5
ENST00000310373.7
ENST00000333884.2
GP6
glycoprotein VI platelet
chr2_+_43838963 0.05 ENST00000272286.4
ABCG8
ATP binding cassette subfamily G member 8
chr8_+_123182635 0.05 ENST00000276699.10
ENST00000522648.5
FAM83A
family with sequence similarity 83 member A
chr1_+_25272439 0.05 ENST00000648012.1
RHD
Rh blood group D antigen
chr5_+_132556911 0.05 ENST00000651541.1
ENST00000378823.8
ENST00000652485.1
RAD50
RAD50 double strand break repair protein
chr5_-_135954962 0.05 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr1_-_149886652 0.04 ENST00000369155.3
H2BC21
H2B clustered histone 21
chr12_+_6310669 0.04 ENST00000684764.1
PLEKHG6
pleckstrin homology and RhoGEF domain containing G6
chr17_+_4771878 0.04 ENST00000270560.4
TM4SF5
transmembrane 4 L six family member 5
chr19_-_11384299 0.04 ENST00000592375.6
ENST00000222139.11
EPOR
erythropoietin receptor
chr15_-_63833911 0.04 ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
ENST00000443617.7
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr6_+_31706866 0.03 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr6_-_30160880 0.03 ENST00000376704.3
TRIM10
tripartite motif containing 10
chr22_-_29388530 0.03 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
AP1B1
adaptor related protein complex 1 subunit beta 1
chr19_-_51019699 0.03 ENST00000358789.8
KLK10
kallikrein related peptidase 10
chr16_+_31527876 0.03 ENST00000302312.9
ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr20_+_44401269 0.03 ENST00000443598.6
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4 alpha
chr19_+_35641728 0.03 ENST00000619399.4
ENST00000379026.6
ENST00000379023.8
ENST00000402764.6
ENST00000479824.5
ETV2
ETS variant transcription factor 2
chr14_+_75522531 0.02 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr7_+_128739292 0.02 ENST00000535011.6
ENST00000542996.6
ENST00000249364.9
ENST00000449187.6
CALU
calumenin
chr2_+_168901290 0.02 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
G6PC2
glucose-6-phosphatase catalytic subunit 2
chr12_+_53425070 0.02 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor type 2
chr7_+_142760398 0.02 ENST00000632998.1
PRSS2
serine protease 2
chr17_+_19411220 0.02 ENST00000461366.2
RNF112
ring finger protein 112
chr8_-_144792380 0.02 ENST00000532702.1
ENST00000394920.6
ENST00000528957.6
ENST00000527914.5
RPL8
ribosomal protein L8
chr2_+_3595049 0.02 ENST00000236693.11
ENST00000349077.9
COLEC11
collectin subfamily member 11
chr19_+_35358821 0.02 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr14_+_21477177 0.02 ENST00000448790.7
ENST00000673643.1
ENST00000457430.2
ENST00000673911.1
TOX4
TOX high mobility group box family member 4
chr14_-_21476874 0.02 ENST00000649801.1
ENST00000397762.6
RAB2B
RAB2B, member RAS oncogene family
chr18_-_48137295 0.02 ENST00000535628.6
ZBTB7C
zinc finger and BTB domain containing 7C
chr7_+_142749465 0.02 ENST00000486171.5
ENST00000619214.4
ENST00000311737.12
PRSS1
serine protease 1
chrX_+_108044967 0.01 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_9999176 0.01 ENST00000298527.10
ENST00000348658.4
CLEC1B
C-type lectin domain family 1 member B
chrX_+_38006551 0.01 ENST00000297875.7
SYTL5
synaptotagmin like 5
chr1_-_42164737 0.01 ENST00000357001.3
GUCA2A
guanylate cyclase activator 2A
chr4_-_102345196 0.01 ENST00000683412.1
ENST00000682227.1
SLC39A8
solute carrier family 39 member 8
chr1_+_12464912 0.00 ENST00000543766.2
VPS13D
vacuolar protein sorting 13 homolog D
chr10_-_20897288 0.00 ENST00000377122.9
NEBL
nebulette
chr17_+_4932285 0.00 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr20_+_56392607 0.00 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr12_-_114403898 0.00 ENST00000526441.1
TBX5
T-box transcription factor 5
chr19_+_35358460 0.00 ENST00000327809.5
FFAR3
free fatty acid receptor 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.1 0.3 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.4 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.2 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.2 GO:0015793 glycerol transport(GO:0015793)
0.0 0.8 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.0 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.7 GO:0000305 response to oxygen radical(GO:0000305)
0.0 0.1 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins