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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for GFI1
Z-value: 1.55
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Transcription factors associated with GFI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1 | hg38_v1_chr1_-_92483947_92483960, hg38_v1_chr1_-_92486049_92486104, hg38_v1_chr1_-_92486916_92486932 | -0.05 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.1 | GO:0007286 | spermatid development(GO:0007286) |
| 0.3 | 11.6 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.0 | 10.5 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 1.0 | 8.4 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.0 | 8.3 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 7.9 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.6 | 7.0 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 6.5 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.9 | 6.4 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.2 | 6.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 21.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 8.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 7.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 6.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 6.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.2 | 4.0 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 3.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 3.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.7 | 3.4 | GO:0048179 | activin receptor complex(GO:0048179) |
| 1.1 | 3.2 | GO:0055028 | cortical microtubule(GO:0055028) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 18.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 15.3 | GO:0003779 | actin binding(GO:0003779) |
| 0.4 | 8.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.3 | 5.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.3 | 5.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 5.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.2 | 5.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 4.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 17.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 10.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 8.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 7.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 6.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 5.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 3.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 2.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 7.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 6.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 5.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 5.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 5.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 5.0 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 4.5 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 3.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 2.9 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |