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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for GLI3
Z-value: 0.77
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Transcription factors associated with GLI3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI3 | hg38_v1_chr7_-_42237187_42237216, hg38_v1_chr7_-_42152396_42152440 | -0.42 | 3.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_120914549 Show fit | 1.66 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr10_-_48493641 Show fit | 1.41 |
ENST00000417247.6
|
Rho GTPase activating protein 22 |
|
| chr5_+_114433508 Show fit | 1.40 |
ENST00000503706.5
|
potassium calcium-activated channel subfamily N member 2 |
|
| chr16_-_11587162 Show fit | 1.32 |
ENST00000570904.5
ENST00000574701.5 |
lipopolysaccharide induced TNF factor |
|
| chr19_+_676385 Show fit | 1.22 |
ENST00000166139.9
|
follistatin like 3 |
|
| chr4_+_153684241 Show fit | 1.19 |
ENST00000646219.1
ENST00000642580.1 ENST00000643501.1 ENST00000642700.2 |
toll like receptor 2 |
|
| chr1_+_183186238 Show fit | 1.14 |
ENST00000493293.5
ENST00000264144.5 |
laminin subunit gamma 2 |
|
| chr22_-_50526337 Show fit | 1.11 |
ENST00000651490.1
ENST00000543927.6 |
thymidine phosphorylase synthesis of cytochrome C oxidase 2 |
|
| chr22_-_19524400 Show fit | 1.03 |
ENST00000618236.2
|
claudin 5 |
|
| chr1_-_205813177 Show fit | 1.03 |
ENST00000367137.4
|
solute carrier family 41 member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.0 | 2.1 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.1 | 1.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 1.6 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.1 | 1.5 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.3 | 1.4 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 0.1 | 1.3 | GO:0030578 | PML body organization(GO:0030578) |
| 0.4 | 1.2 | GO:0070340 | central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) |
| 0.1 | 1.2 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 1.2 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.5 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.2 | 1.4 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 1.4 | GO:0043256 | laminin complex(GO:0043256) |
| 0.0 | 1.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.4 | 1.2 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.0 | 1.2 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.9 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.1 | 0.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 0.7 | GO:0097451 | glial limiting end-foot(GO:0097451) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 1.6 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.5 | 1.5 | GO:0016154 | thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154) |
| 0.3 | 1.4 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.2 | 1.4 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.0 | 1.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 1.3 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 1.3 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.1 | 1.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 1.1 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.9 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.1 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 1.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.8 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.7 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 1.3 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 1.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.2 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 1.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.9 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |