ISMARA results: GLIS1

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for GLIS1

Z-value: 0.11

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Transcription factors associated with GLIS1

Gene Symbol	Gene ID	Gene Info
GLIS1 Ensembl NCBI GeneCards UniProt	ENSG00000174332.5	GLIS1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GLIS1	hg38_v1_chr1_-_53738024_53738106	-0.29	1.5e-01	Click!

Activity profile of GLIS1 motif

Sorted Z-values of GLIS1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr7_+_107044689 Show fit	0.38	ENST00000265717.5	PRKAR2B Ensembl NCBI GeneCards UniProt Show fit	protein kinase cAMP-dependent type II regulatory subunit beta
chr16_+_58025745 Show fit	0.11	ENST00000219271.4	MMP15 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 15
chr11_+_68903849 Show fit	0.10	ENST00000675615.1 ENST00000255078.8	IGHMBP2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin mu DNA binding protein 2
chr11_-_68903796 Show fit	0.08	ENST00000362034.7	MRPL21 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L21
chr18_+_11751467 Show fit	0.05	ENST00000535121.5	GNAL Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha L
chr19_-_49325181 Show fit	0.05	ENST00000454748.7 ENST00000335875.9 ENST00000598828.1	SLC6A16 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 16
chr18_+_11751494 Show fit	0.05	ENST00000269162.9	GNAL Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha L
chr18_-_63158208 Show fit	0.05	ENST00000678301.1	BCL2 Ensembl NCBI GeneCards UniProt Show fit	BCL2 apoptosis regulator
chr19_-_41959266 Show fit	0.01	ENST00000600292.5 ENST00000601078.5 ENST00000601891.5 ENST00000222008.11	RABAC1 Ensembl NCBI GeneCards UniProt Show fit	Rab acceptor 1

Showing 1 to 9 of 9 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097338	response to clozapine(GO:0097338)
0.0	0.0	GO:0043375	negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)

Showing 1 to 2 of 2 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)

Showing 1 to 1 of 1 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)

Showing 1 to 2 of 2 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway

Showing 1 to 2 of 2 entries

Results for GLIS1

Z-value: 0.11

Motif logo

Transcription factors associated with GLIS1

Activity-expression correlation:

Activity profile of GLIS1 motif

Sorted Z-values of GLIS1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: