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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for GLIS3

Z-value: 0.46

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.24 GLIS3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLIS3hg38_v1_chr9_-_4300049_4300120,
hg38_v1_chr9_-_4299547_4299597		0.154.6e-01Click!

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_107044689 1.65 ENST00000265717.5
PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
chrX_-_126552801 1.50 ENST00000371126.3
DCAF12L1
DDB1 and CUL4 associated factor 12 like 1
chr12_+_52949107 1.18 ENST00000388835.4
KRT18
keratin 18
chr1_-_209806124 1.03 ENST00000367021.8
ENST00000542854.5
IRF6
interferon regulatory factor 6
chr20_+_21125999 0.90 ENST00000620891.4
KIZ
kizuna centrosomal protein
chr20_+_21125981 0.85 ENST00000619574.4
KIZ
kizuna centrosomal protein
chr20_+_21126037 0.83 ENST00000611685.4
ENST00000616848.4
KIZ
kizuna centrosomal protein
chr20_+_21126074 0.81 ENST00000619189.5
KIZ
kizuna centrosomal protein
chr18_-_48950960 0.80 ENST00000262158.8
SMAD7
SMAD family member 7
chr8_-_29263063 0.76 ENST00000524189.6
KIF13B
kinesin family member 13B
chr6_+_24494939 0.75 ENST00000348925.2
ENST00000357578.8
ALDH5A1
aldehyde dehydrogenase 5 family member A1
chr16_-_90008988 0.65 ENST00000568662.2
DBNDD1
dysbindin domain containing 1
chr2_-_85602681 0.59 ENST00000334462.10
ENST00000306353.7
TMEM150A
transmembrane protein 150A
chr2_-_85602351 0.54 ENST00000409668.1
TMEM150A
transmembrane protein 150A
chr10_-_125161019 0.51 ENST00000411419.6
CTBP2
C-terminal binding protein 2
chr19_-_42255119 0.45 ENST00000222329.9
ENST00000594664.1
ERF
ENSG00000268643.2
ETS2 repressor factor
novel protein
chr14_+_104724221 0.43 ENST00000330877.7
ADSS1
adenylosuccinate synthase 1
chr19_-_41353904 0.42 ENST00000221930.6
TGFB1
transforming growth factor beta 1
chr19_+_41354145 0.41 ENST00000604123.5
TMEM91
transmembrane protein 91
chr19_+_13764502 0.36 ENST00000040663.8
ENST00000319545.12
MRI1
methylthioribose-1-phosphate isomerase 1
chr1_+_2019379 0.35 ENST00000638771.1
ENST00000640949.1
ENST00000640030.1
GABRD
gamma-aminobutyric acid type A receptor subunit delta
chr6_+_89081787 0.34 ENST00000354922.3
PNRC1
proline rich nuclear receptor coactivator 1
chr1_-_52552994 0.34 ENST00000355809.4
ENST00000528642.5
ENST00000470626.1
ENST00000257177.9
ENST00000371544.7
TUT4
terminal uridylyl transferase 4
chr1_-_53945584 0.31 ENST00000371377.3
HSPB11
heat shock protein family B (small) member 11
chr9_-_95516959 0.30 ENST00000437951.6
ENST00000430669.6
ENST00000468211.6
PTCH1
patched 1
chr1_-_53945567 0.29 ENST00000371378.6
HSPB11
heat shock protein family B (small) member 11
chr17_+_50834581 0.28 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr15_+_83447411 0.28 ENST00000324537.5
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr4_-_83334782 0.27 ENST00000681769.1
ENST00000513463.1
ENST00000311412.10
HPSE
heparanase
chr3_-_160449721 0.27 ENST00000479460.5
TRIM59
tripartite motif containing 59
chr18_-_63158208 0.27 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr5_+_41925223 0.27 ENST00000296812.6
ENST00000281623.8
ENST00000509134.1
FBXO4
F-box protein 4
chr17_-_75182536 0.26 ENST00000578238.2
SUMO2
small ubiquitin like modifier 2
chr22_+_22644475 0.26 ENST00000618722.4
ENST00000652219.1
ENST00000480559.6
ENST00000448514.2
ENST00000652249.1
ENST00000651213.1
GGTLC2
gamma-glutamyltransferase light chain 2
chr9_-_136304084 0.25 ENST00000638797.2
ENST00000624277.3
CCDC187
coiled-coil domain containing 187
chr19_-_10503186 0.24 ENST00000592055.2
ENST00000171111.10
KEAP1
kelch like ECH associated protein 1
chr10_+_22321056 0.24 ENST00000376663.8
BMI1
BMI1 proto-oncogene, polycomb ring finger
chr10_+_61901678 0.23 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr9_-_113299196 0.23 ENST00000441031.3
RNF183
ring finger protein 183
chr17_-_5111836 0.23 ENST00000575898.5
ZNF232
zinc finger protein 232
chr16_+_69187125 0.22 ENST00000336278.8
SNTB2
syntrophin beta 2
chr1_+_2019324 0.22 ENST00000638411.1
ENST00000378585.7
ENST00000640067.1
GABRD
gamma-aminobutyric acid type A receptor subunit delta
chr16_+_89686661 0.21 ENST00000505473.5
ENST00000353379.12
ENST00000625631.1
ENST00000564192.5
CDK10
cyclin dependent kinase 10
chr11_+_68903849 0.21 ENST00000675615.1
ENST00000255078.8
IGHMBP2
immunoglobulin mu DNA binding protein 2
chr4_+_163343882 0.20 ENST00000338566.8
NPY5R
neuropeptide Y receptor Y5
chr14_+_22462932 0.20 ENST00000390477.2
TRDC
T cell receptor delta constant
chr17_+_76000906 0.19 ENST00000448471.2
CDK3
cyclin dependent kinase 3
chr11_-_68903796 0.19 ENST00000362034.7
MRPL21
mitochondrial ribosomal protein L21
chr17_+_7888783 0.18 ENST00000330494.12
ENST00000358181.8
CHD3
chromodomain helicase DNA binding protein 3
chr17_+_47941562 0.18 ENST00000225573.5
ENST00000434554.7
ENST00000642017.2
PNPO
pyridoxamine 5'-phosphate oxidase
chr18_+_11751494 0.17 ENST00000269162.9
GNAL
G protein subunit alpha L
chr1_-_45521931 0.17 ENST00000447184.6
ENST00000262746.5
PRDX1
peroxiredoxin 1
chr18_+_11751467 0.16 ENST00000535121.5
GNAL
G protein subunit alpha L
chrX_+_119236245 0.16 ENST00000535419.2
PGRMC1
progesterone receptor membrane component 1
chr22_+_31093358 0.16 ENST00000404574.5
SMTN
smoothelin
chr3_-_160449530 0.15 ENST00000494486.1
TRIM59
tripartite motif containing 59
chr19_-_10502745 0.15 ENST00000393623.6
KEAP1
kelch like ECH associated protein 1
chr1_-_45521854 0.15 ENST00000372079.1
ENST00000319248.13
PRDX1
peroxiredoxin 1
chr12_-_47758828 0.15 ENST00000389212.7
ENST00000449771.7
RAPGEF3
Rap guanine nucleotide exchange factor 3
chr1_-_19799872 0.15 ENST00000294543.11
TMCO4
transmembrane and coiled-coil domains 4
chr19_-_3061403 0.15 ENST00000586839.1
TLE5
TLE family member 5, transcriptional modulator
chrX_+_119236274 0.14 ENST00000217971.8
PGRMC1
progesterone receptor membrane component 1
chr9_-_136764515 0.14 ENST00000316144.6
LCN15
lipocalin 15
chr17_-_58527980 0.13 ENST00000583114.5
SEPTIN4
septin 4
chr3_-_25783434 0.13 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
NGLY1
N-glycanase 1
chr5_-_179623098 0.12 ENST00000630639.1
ENST00000329433.10
ENST00000510411.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr5_+_172959416 0.12 ENST00000265100.6
ENST00000519239.5
RPL26L1
ribosomal protein L26 like 1
chr11_+_818906 0.12 ENST00000336615.9
PNPLA2
patatin like phospholipase domain containing 2
chr3_-_160449752 0.12 ENST00000496222.1
ENST00000471396.1
ENST00000471155.5
ENST00000309784.9
TRIM59
tripartite motif containing 59
chr1_-_45522870 0.11 ENST00000424390.2
PRDX1
peroxiredoxin 1
chr1_+_22637580 0.11 ENST00000402322.1
C1QA
complement C1q A chain
chr15_+_90935277 0.11 ENST00000418476.2
UNC45A
unc-45 myosin chaperone A
chr1_+_107056656 0.11 ENST00000370078.2
PRMT6
protein arginine methyltransferase 6
chr3_-_25783381 0.09 ENST00000308710.9
ENST00000676225.1
NGLY1
N-glycanase 1
chr6_+_44223553 0.09 ENST00000371740.10
ENST00000371755.9
ENST00000643869.1
ENST00000371731.6
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr18_+_3451585 0.09 ENST00000551541.5
TGIF1
TGFB induced factor homeobox 1
chr6_+_44223770 0.08 ENST00000652453.1
ENST00000393841.6
ENST00000371724.6
ENST00000642777.1
ENST00000645692.1
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr18_+_3451647 0.08 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chr19_-_14114156 0.08 ENST00000589994.6
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
chr17_-_35119733 0.06 ENST00000460118.6
ENST00000335858.11
RAD51D
RAD51 paralog D
chr2_-_240820205 0.06 ENST00000647731.1
ENST00000648680.1
ENST00000649306.1
ENST00000648129.1
ENST00000498729.9
ENST00000320389.12
ENST00000648364.1
ENST00000647885.1
ENST00000404283.9
ENST00000649096.1
KIF1A
kinesin family member 1A
chr8_+_27325516 0.06 ENST00000346049.10
ENST00000420218.3
PTK2B
protein tyrosine kinase 2 beta
chr2_+_218959635 0.06 ENST00000302625.6
CDK5R2
cyclin dependent kinase 5 regulatory subunit 2
chr5_-_168883333 0.05 ENST00000404867.7
SLIT3
slit guidance ligand 3
chr12_+_1820255 0.04 ENST00000543818.5
LRTM2
leucine rich repeats and transmembrane domains 2
chr17_-_35119801 0.03 ENST00000592577.5
ENST00000590016.5
ENST00000345365.11
RAD51D
RAD51 paralog D
chr3_+_101724602 0.03 ENST00000341893.8
CEP97
centrosomal protein 97
chr5_-_179623659 0.02 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr2_-_240820945 0.02 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
KIF1A
kinesin family member 1A
chr3_+_37987970 0.02 ENST00000283713.10
VILL
villin like
chr1_-_42335869 0.01 ENST00000372573.5
FOXJ3
forkhead box J3
chr1_-_160285120 0.01 ENST00000368072.10
PEX19
peroxisomal biogenesis factor 19
chr6_+_33204645 0.01 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043000 Golgi to plasma membrane CFTR protein transport(GO:0043000)
0.2 1.7 GO:0097338 response to clozapine(GO:0097338)
0.2 0.7 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.4 GO:0052510 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.1 0.8 GO:2000320 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.8 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1 0.3 GO:0010157 response to chlorate(GO:0010157)
0.1 0.3 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.3 GO:0032848 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.2 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 1.0 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.6 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.1 GO:0030807 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822)
0.0 0.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 3.2 GO:0007051 spindle organization(GO:0007051)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.8 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.5 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0032797 SMN complex(GO:0032797)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0046930 pore complex(GO:0046930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.1 1.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 1.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.1 0.2 GO:0001601 peptide YY receptor activity(GO:0001601)
0.1 0.3 GO:0005119 smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108)
0.0 0.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins