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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for GMEB2
Z-value: 1.02
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Transcription factors associated with GMEB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB2 | hg38_v1_chr20_-_63627049_63627113 | -0.15 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 1.1 | 3.2 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.2 | 2.4 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 2.2 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.1 | 2.1 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.2 | 2.0 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.0 | 1.9 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.0 | 1.8 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 1.7 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 1.5 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.3 | 2.2 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 2.2 | GO:0005814 | centriole(GO:0005814) |
| 0.5 | 1.6 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.1 | 1.6 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 1.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 1.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.3 | 1.4 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 1.4 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 1.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 2.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.6 | 2.4 | GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 0.0 | 2.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.2 | 2.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.3 | 1.7 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.0 | 1.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 1.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.5 | 1.6 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 0.1 | 1.6 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 2.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 1.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.1 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.0 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 1.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 3.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.3 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 2.1 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 1.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.1 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 1.1 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.1 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |