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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for GRHL1

Z-value: 0.53

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.18 GRHL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg38_v1_chr2_+_9951653_99517340.331.1e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_155666718 2.95 ENST00000621234.4
ENST00000511108.5
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155667198 2.76 ENST00000296518.11
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155667096 2.74 ENST00000393832.7
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155666963 2.65 ENST00000455639.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155666827 1.76 ENST00000511507.5
ENST00000506455.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr9_-_75088198 1.10 ENST00000376808.8
NMRK1
nicotinamide riboside kinase 1
chr2_-_208254232 1.05 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chr9_+_5450503 0.82 ENST00000381573.8
ENST00000381577.4
CD274
CD274 molecule
chr3_-_172523460 0.69 ENST00000420541.6
TNFSF10
TNF superfamily member 10
chr20_-_25339731 0.66 ENST00000450393.5
ENST00000491682.5
ABHD12
abhydrolase domain containing 12, lysophospholipase
chr3_-_172523423 0.63 ENST00000241261.7
TNFSF10
TNF superfamily member 10
chr19_+_44809053 0.61 ENST00000611077.5
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr1_+_210232776 0.58 ENST00000367012.4
SERTAD4
SERTA domain containing 4
chr19_-_291132 0.55 ENST00000327790.7
PLPP2
phospholipid phosphatase 2
chr19_+_10625507 0.53 ENST00000590857.5
ENST00000588688.5
ENST00000586078.5
ENST00000335757.10
SLC44A2
solute carrier family 44 member 2
chr3_-_49104457 0.47 ENST00000635292.1
ENST00000635541.1
ENST00000464962.6
QARS1
glutaminyl-tRNA synthetase 1
chr3_-_49104745 0.47 ENST00000635194.1
ENST00000306125.12
ENST00000634602.1
ENST00000414533.5
ENST00000635443.1
ENST00000452739.5
ENST00000635231.1
QARS1
glutaminyl-tRNA synthetase 1
chr19_+_44809089 0.46 ENST00000270233.12
ENST00000591520.6
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr12_-_10807286 0.44 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr19_-_11738882 0.43 ENST00000586121.1
ENST00000431998.1
ENST00000341191.11
ENST00000440527.1
ZNF823
zinc finger protein 823
chr1_-_52055156 0.41 ENST00000371626.9
ENST00000610127.2
TXNDC12
thioredoxin domain containing 12
chr20_-_62427528 0.40 ENST00000252998.2
RBBP8NL
RBBP8 N-terminal like
chr7_+_76510516 0.40 ENST00000257632.9
UPK3B
uroplakin 3B
chr6_-_46921926 0.40 ENST00000283296.12
ADGRF5
adhesion G protein-coupled receptor F5
chr7_+_76510608 0.39 ENST00000394849.1
UPK3B
uroplakin 3B
chr7_+_76510528 0.38 ENST00000334348.8
UPK3B
uroplakin 3B
chr1_-_24143112 0.28 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr18_-_57803307 0.28 ENST00000648908.2
ATP8B1
ATPase phospholipid transporting 8B1
chr9_+_75088498 0.27 ENST00000346234.7
OSTF1
osteoclast stimulating factor 1
chr6_+_32153441 0.25 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
PPT2
palmitoyl-protein thioesterase 2
chr8_-_129786617 0.24 ENST00000276708.9
GSDMC
gasdermin C
chr11_-_64166102 0.24 ENST00000255681.7
ENST00000675777.1
MACROD1
mono-ADP ribosylhydrolase 1
chr14_+_50533026 0.22 ENST00000441560.6
ATL1
atlastin GTPase 1
chr17_-_4560564 0.21 ENST00000574584.1
ENST00000381550.8
ENST00000301395.7
GGT6
gamma-glutamyltransferase 6
chr1_-_50960230 0.19 ENST00000396153.7
FAF1
Fas associated factor 1
chr11_+_706595 0.19 ENST00000531348.5
ENST00000530636.5
EPS8L2
EPS8 like 2
chr2_+_190408324 0.18 ENST00000417958.5
ENST00000432036.5
ENST00000392328.6
MFSD6
major facilitator superfamily domain containing 6
chr19_-_43504711 0.18 ENST00000601646.1
PHLDB3
pleckstrin homology like domain family B member 3
chr13_+_48232609 0.18 ENST00000649266.1
ITM2B
integral membrane protein 2B
chr12_+_18261511 0.17 ENST00000538779.6
ENST00000433979.6
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr1_+_94418435 0.15 ENST00000647998.2
ABCD3
ATP binding cassette subfamily D member 3
chr5_+_181040260 0.15 ENST00000515271.1
ENST00000327705.14
BTNL9
butyrophilin like 9
chr7_-_102543849 0.14 ENST00000644544.1
UPK3BL2
uroplakin 3B like 2
chr11_-_65780917 0.14 ENST00000532090.3
AP5B1
adaptor related protein complex 5 subunit beta 1
chr15_+_41838839 0.13 ENST00000458483.4
PLA2G4B
phospholipase A2 group IVB
chr12_-_3753091 0.12 ENST00000252322.1
ENST00000440314.7
CRACR2A
calcium release activated channel regulator 2A
chr13_+_48233171 0.12 ENST00000378549.5
ENST00000647800.2
ITM2B
integral membrane protein 2B
chr6_-_31139063 0.12 ENST00000259845.5
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr11_+_65787056 0.12 ENST00000335987.8
OVOL1
ovo like transcriptional repressor 1
chr7_-_102642791 0.12 ENST00000340457.8
UPK3BL1
uroplakin 3B like 1
chr11_-_67674606 0.12 ENST00000674110.1
ENST00000349015.7
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr11_-_67674725 0.10 ENST00000525827.6
ENST00000673966.1
ENST00000673873.1
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr11_+_119168188 0.10 ENST00000454811.5
ENST00000409265.8
ENST00000449394.5
NLRX1
NLR family member X1
chr22_+_18077976 0.09 ENST00000399744.8
PEX26
peroxisomal biogenesis factor 26
chr11_+_119168705 0.08 ENST00000409109.6
ENST00000409991.5
ENST00000292199.6
NLRX1
NLR family member X1
chr1_-_36397880 0.07 ENST00000315732.3
LSM10
LSM10, U7 small nuclear RNA associated
chr1_+_40258202 0.07 ENST00000372759.4
ZMPSTE24
zinc metallopeptidase STE24
chr1_-_153608136 0.07 ENST00000368703.6
S100A16
S100 calcium binding protein A16
chr1_+_43974902 0.03 ENST00000532642.5
ENST00000236067.8
ENST00000471859.6
ENST00000472174.7
ATP6V0B
ATPase H+ transporting V0 subunit b
chr18_+_9474994 0.03 ENST00000019317.8
RALBP1
ralA binding protein 1
chr19_+_11925098 0.03 ENST00000254321.10
ENST00000591944.1
ZNF700
ENSG00000267179.1
zinc finger protein 700
novel protein
chr19_+_11925062 0.03 ENST00000622593.4
ENST00000590798.1
ZNF700
ENSG00000267179.1
zinc finger protein 700
novel protein
chr1_+_34782259 0.02 ENST00000373362.3
GJB3
gap junction protein beta 3
chr20_-_18057841 0.02 ENST00000278780.7
OVOL2
ovo like zinc finger 2
chr14_-_80211472 0.02 ENST00000557125.1
ENST00000438257.9
ENST00000422005.7
DIO2
iodothyronine deiodinase 2
chr19_-_17245889 0.01 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr5_+_134967901 0.01 ENST00000282611.8
CATSPER3
cation channel sperm associated 3
chr14_+_23469681 0.01 ENST00000408901.8
ENST00000397154.7
ENST00000555128.5
NGDN
neuroguidin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 0.7 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.8 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 1.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:1901993 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.3 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.4 GO:0043129 surfactant homeostasis(GO:0043129) positive regulation of phospholipid biosynthetic process(GO:0071073)
0.0 0.5 GO:0015871 choline transport(GO:0015871)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.3 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 1.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0005055 laminin receptor activity(GO:0005055)
0.3 1.0 GO:0051990 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.3 1.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 0.6 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0016671 peptide disulfide oxidoreductase activity(GO:0015037) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.3 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0004030 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID TRAIL PATHWAY TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC