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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for GSC_GSC2
Z-value: 0.57
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Transcription factors associated with GSC_GSC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GSC | hg38_v1_chr14_-_94770102_94770130 | 0.22 | 2.9e-01 | Click! |
| GSC2 | hg38_v1_chr22_-_19150292_19150292 | 0.05 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GSC_GSC2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_55511434 Show fit | 0.76 |
ENST00000636752.1
|
small integral membrane protein 36 |
|
| chr19_+_2476118 Show fit | 0.63 |
ENST00000215631.9
ENST00000587345.1 |
growth arrest and DNA damage inducible beta |
|
| chr8_+_69466617 Show fit | 0.63 |
ENST00000525061.5
ENST00000260128.8 ENST00000458141.6 |
sulfatase 1 |
|
| chr2_-_55269038 Show fit | 0.60 |
ENST00000417363.5
ENST00000412530.1 ENST00000366137.6 ENST00000420637.5 |
mitochondrial translational initiation factor 2 |
|
| chr17_+_4740005 Show fit | 0.58 |
ENST00000269289.10
|
zinc finger MYND-type containing 15 |
|
| chr17_+_4740042 Show fit | 0.58 |
ENST00000592813.5
|
zinc finger MYND-type containing 15 |
|
| chr2_-_70553440 Show fit | 0.57 |
ENST00000450929.5
|
transforming growth factor alpha |
|
| chr12_+_6840800 Show fit | 0.57 |
ENST00000541978.5
ENST00000229264.8 ENST00000435982.6 |
G protein subunit beta 3 |
|
| chr17_+_4739791 Show fit | 0.56 |
ENST00000433935.6
|
zinc finger MYND-type containing 15 |
|
| chrX_+_136197020 Show fit | 0.54 |
ENST00000370676.7
|
four and a half LIM domains 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 0.8 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.7 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.0 | 0.7 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.2 | 0.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.0 | 0.6 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.2 | 0.5 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.0 | 0.5 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.5 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.0 | 0.5 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.4 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.3 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.2 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.0 | 0.2 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.0 | 0.1 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.6 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.5 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 0.4 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 0.3 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 0.3 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 0.3 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.0 | 0.3 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |