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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for GTF2I
Z-value: 1.76
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Transcription factors associated with GTF2I
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2I | hg38_v1_chr7_+_74657745_74657793 | 0.79 | 2.9e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GTF2I
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_16898561 Show fit | 10.53 |
ENST00000515064.5
ENST00000441778.6 |
LIM domain binding 2 |
|
| chr4_-_16898619 Show fit | 9.38 |
ENST00000502640.5
ENST00000304523.10 ENST00000506732.1 |
LIM domain binding 2 |
|
| chr17_-_44199206 Show fit | 7.54 |
ENST00000589805.1
|
ataxin 7 like 3 |
|
| chr11_+_125164743 Show fit | 7.00 |
ENST00000298282.14
|
PBX/knotted 1 homeobox 2 |
|
| chr5_-_81751022 Show fit | 6.92 |
ENST00000509013.2
ENST00000505980.5 ENST00000509053.5 |
single stranded DNA binding protein 2 |
|
| chr5_-_81751085 Show fit | 5.83 |
ENST00000515395.5
|
single stranded DNA binding protein 2 |
|
| chr19_-_14090695 Show fit | 4.96 |
ENST00000533683.7
|
sterile alpha motif domain containing 1 |
|
| chr7_+_30911845 Show fit | 4.67 |
ENST00000652696.1
ENST00000311813.11 |
aquaporin 1 (Colton blood group) |
|
| chr6_-_142946312 Show fit | 4.62 |
ENST00000367604.6
|
HIVEP zinc finger 2 |
|
| chr14_-_53956811 Show fit | 4.62 |
ENST00000559087.5
ENST00000245451.9 |
bone morphogenetic protein 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 20.7 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.5 | 16.1 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 14.5 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.0 | 8.6 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.2 | 8.2 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.1 | 7.4 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.2 | 6.0 | GO:0009650 | UV protection(GO:0009650) |
| 0.8 | 5.9 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 0.2 | 5.9 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.2 | 5.7 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 16.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.6 | 15.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 11.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 8.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.5 | 7.6 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 5.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 5.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.2 | 4.7 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.0 | 4.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 20.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 18.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 16.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 10.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 5.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.2 | 5.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 5.2 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.6 | 4.8 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 4.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 4.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 8.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 8.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 5.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 5.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 4.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.3 | 4.7 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 7.4 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.2 | 7.1 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.1 | 5.8 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 5.1 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 5.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 4.9 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.3 | 4.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 4.2 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 3.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |