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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for GZF1

Z-value: 0.42

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Transcription factors associated with GZF1

Gene Symbol Gene ID Gene Info
GZF1
ENSG00000125812.16 GZF1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GZF1hg38_v1_chr20_+_23362144_233623200.481.5e-02Click!

Activity profile of GZF1 motif

Sorted Z-values of GZF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_79767987 2.19 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr1_+_78649818 1.52 ENST00000370747.9
ENST00000438486.1
IFI44
interferon induced protein 44
chr14_-_52069228 0.57 ENST00000617139.4
NID2
nidogen 2
chr14_-_52069039 0.57 ENST00000216286.10
NID2
nidogen 2
chr17_-_38748184 0.43 ENST00000618941.4
ENST00000620225.5
ENST00000618506.1
ENST00000616129.4
PCGF2
polycomb group ring finger 2
chr10_+_96000091 0.43 ENST00000424464.5
ENST00000410012.6
ENST00000344386.3
CC2D2B
coiled-coil and C2 domain containing 2B
chr1_-_120051714 0.41 ENST00000579475.7
NOTCH2
notch receptor 2
chr12_+_106774630 0.37 ENST00000392839.6
ENST00000548914.5
ENST00000355478.6
ENST00000552619.1
ENST00000549643.5
ENST00000392837.9
RIC8B
RIC8 guanine nucleotide exchange factor B
chr10_+_58269132 0.36 ENST00000333926.6
CISD1
CDGSH iron sulfur domain 1
chr1_+_9651723 0.35 ENST00000377346.9
ENST00000536656.5
ENST00000628140.2
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
chr1_+_148889403 0.35 ENST00000464103.5
ENST00000534536.5
ENST00000369356.8
ENST00000369354.7
ENST00000369347.8
ENST00000369349.7
ENST00000369351.7
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_12995467 0.28 ENST00000592199.6
NFIX
nuclear factor I X
chr19_+_35666515 0.26 ENST00000617999.4
ENST00000616789.4
UPK1A
uroplakin 1A
chr19_+_38390055 0.25 ENST00000587947.5
ENST00000338502.8
SPRED3
sprouty related EVH1 domain containing 3
chr19_-_3786254 0.25 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr16_+_67842277 0.24 ENST00000303596.3
THAP11
THAP domain containing 11
chr1_-_2530256 0.23 ENST00000378453.4
HES5
hes family bHLH transcription factor 5
chr8_-_56113982 0.23 ENST00000311923.1
MOS
MOS proto-oncogene, serine/threonine kinase
chr19_+_926001 0.21 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr6_-_42451261 0.21 ENST00000372917.8
ENST00000340840.6
ENST00000354325.2
TRERF1
transcriptional regulating factor 1
chr19_-_3786408 0.20 ENST00000395040.6
MATK
megakaryocyte-associated tyrosine kinase
chr4_-_146521891 0.19 ENST00000394059.8
ENST00000502607.1
ENST00000335472.12
ENST00000432059.6
SLC10A7
solute carrier family 10 member 7
chr14_-_59484317 0.19 ENST00000247194.9
L3HYPDH
trans-L-3-hydroxyproline dehydratase
chr1_-_41918858 0.18 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr19_-_3786363 0.18 ENST00000310132.11
MATK
megakaryocyte-associated tyrosine kinase
chr7_-_27143672 0.18 ENST00000222726.4
HOXA5
homeobox A5
chr4_-_47463649 0.18 ENST00000381571.6
COMMD8
COMM domain containing 8
chr1_-_41918666 0.17 ENST00000372584.5
HIVEP3
HIVEP zinc finger 3
chr16_+_86578543 0.15 ENST00000320241.5
FOXL1
forkhead box L1
chr6_+_125153846 0.15 ENST00000528193.5
TPD52L1
TPD52 like 1
chr14_-_31457495 0.14 ENST00000310850.9
DTD2
D-aminoacyl-tRNA deacylase 2
chr14_-_59484006 0.14 ENST00000481608.1
L3HYPDH
trans-L-3-hydroxyproline dehydratase
chr5_+_171387757 0.14 ENST00000677297.1
ENST00000521672.6
ENST00000679190.1
ENST00000351986.10
ENST00000676589.1
ENST00000679233.1
ENST00000677357.1
ENST00000296930.10
ENST00000393820.2
ENST00000523622.1
NPM1
nucleophosmin 1
chr17_-_31321743 0.14 ENST00000247270.3
EVI2A
ecotropic viral integration site 2A
chr9_+_134326435 0.13 ENST00000481739.2
RXRA
retinoid X receptor alpha
chr16_+_1612337 0.12 ENST00000674071.1
ENST00000397412.8
CRAMP1
cramped chromatin regulator homolog 1
chr19_-_36054224 0.12 ENST00000292894.2
THAP8
THAP domain containing 8
chr16_-_46763237 0.12 ENST00000536476.5
MYLK3
myosin light chain kinase 3
chr19_-_43880142 0.12 ENST00000324394.7
ZNF404
zinc finger protein 404
chr2_-_149587602 0.11 ENST00000428879.5
ENST00000303319.10
ENST00000422782.2
MMADHC
metabolism of cobalamin associated D
chr1_+_40709475 0.11 ENST00000372651.5
NFYC
nuclear transcription factor Y subunit gamma
chr10_+_92593112 0.10 ENST00000260731.5
KIF11
kinesin family member 11
chr11_+_102047422 0.09 ENST00000434758.7
ENST00000526781.5
ENST00000534360.1
CFAP300
cilia and flagella associated protein 300
chr11_-_17476801 0.09 ENST00000644772.1
ENST00000642271.1
ENST00000684571.1
ENST00000646902.1
ENST00000647015.1
ENST00000302539.9
ENST00000389817.8
ENST00000643260.1
ENST00000683136.1
ABCC8
ATP binding cassette subfamily C member 8
chr7_-_6706843 0.08 ENST00000394917.3
ENST00000342651.9
ENST00000405858.6
ZNF12
zinc finger protein 12
chr1_+_26280117 0.08 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
chr13_+_21671067 0.07 ENST00000382353.6
FGF9
fibroblast growth factor 9
chr1_+_26280059 0.06 ENST00000270792.10
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
chr6_+_30557287 0.06 ENST00000376560.8
PRR3
proline rich 3
chr4_+_26343156 0.06 ENST00000680928.1
ENST00000681260.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chrX_+_153972729 0.06 ENST00000369982.5
TMEM187
transmembrane protein 187
chr12_-_102120065 0.05 ENST00000552283.6
ENST00000551744.2
NUP37
nucleoporin 37
chr6_+_30557274 0.05 ENST00000376557.3
PRR3
proline rich 3
chr19_-_10315737 0.05 ENST00000492239.5
FDX2
ferredoxin 2
chr1_+_40709316 0.05 ENST00000372652.5
NFYC
nuclear transcription factor Y subunit gamma
chr9_+_128371343 0.04 ENST00000372850.5
ENST00000372847.1
ENST00000372853.9
ENST00000483206.2
URM1
ubiquitin related modifier 1
chr14_-_31457417 0.04 ENST00000356180.4
DTD2
D-aminoacyl-tRNA deacylase 2
chr10_-_102120318 0.03 ENST00000673968.1
LDB1
LIM domain binding 1
chr12_+_104064520 0.03 ENST00000229330.9
HCFC2
host cell factor C2
chrX_+_48508949 0.03 ENST00000359882.8
ENST00000326194.11
ENST00000355961.8
ENST00000683923.1
ENST00000489940.5
ENST00000361988.7
PORCN
porcupine O-acyltransferase
chr19_-_10315987 0.03 ENST00000393708.3
ENST00000494368.5
FDX2
ferredoxin 2
chr8_-_41309434 0.02 ENST00000220772.8
SFRP1
secreted frizzled related protein 1
chr20_-_32743406 0.02 ENST00000474815.2
ENST00000446419.6
ENST00000278980.11
ENST00000642484.1
ENST00000646357.1
COMMD7
ENSG00000285382.1
COMM domain containing 7
novel protein
chr10_-_102120246 0.01 ENST00000425280.2
LDB1
LIM domain binding 1
chr19_-_51630401 0.00 ENST00000683636.1
SIGLEC5
sialic acid binding Ig like lectin 5
chr12_+_102120172 0.00 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0050925 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.1 0.2 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.2 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.2 GO:0060435 bronchiole development(GO:0060435)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447) secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.2 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 1.1 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.5 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
0.0 0.0 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 0.2 GO:0006450 regulation of translational fidelity(GO:0006450)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.3 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.0 0.4 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.2 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0070644 9-cis retinoic acid receptor activity(GO:0004886) vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL