Project

Inflammatory response time course, HUVEC (Wada, 2009)

Navigation
Downloads

Results for HDX

Z-value: 0.39

Motif logo

logo of

Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.14 HDX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg38_v1_chrX_-_84502442_84502501-0.582.4e-03Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_6215786 2.87 ENST00000417746.6
ENST00000682010.1
IL33
interleukin 33
chr1_+_84164370 1.96 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr7_+_80135694 1.41 ENST00000457358.7
GNAI1
G protein subunit alpha i1
chr1_+_47023659 1.26 ENST00000371901.4
CYP4X1
cytochrome P450 family 4 subfamily X member 1
chr2_-_191020960 1.16 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1
chr3_-_165837412 0.68 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
BCHE
butyrylcholinesterase
chr1_+_84164684 0.55 ENST00000370680.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr19_-_57974527 0.42 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr3_+_107523026 0.40 ENST00000416476.6
BBX
BBX high mobility group box domain containing
chr5_-_135954962 0.35 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr5_-_35230332 0.33 ENST00000504500.5
PRLR
prolactin receptor
chr11_+_9664061 0.28 ENST00000447399.6
ENST00000318950.11
SWAP70
switching B cell complex subunit SWAP70
chr2_+_169069537 0.28 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chr3_+_107522936 0.23 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX
BBX high mobility group box domain containing
chr22_+_40044802 0.23 ENST00000441751.5
ENST00000301923.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr5_+_140786291 0.22 ENST00000394633.7
PCDHA1
protocadherin alpha 1
chr19_+_36111151 0.22 ENST00000633214.1
ENST00000585332.3
OVOL3
ovo like zinc finger 3
chr3_+_54123452 0.18 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr1_-_48400826 0.17 ENST00000371841.1
SPATA6
spermatogenesis associated 6
chr7_+_142800957 0.17 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr6_+_32969345 0.16 ENST00000678250.1
BRD2
bromodomain containing 2
chr1_-_110519175 0.15 ENST00000369771.4
KCNA10
potassium voltage-gated channel subfamily A member 10
chr2_+_127646145 0.12 ENST00000486700.2
ENST00000272644.7
GPR17
G protein-coupled receptor 17
chr20_-_37158904 0.10 ENST00000417458.5
MROH8
maestro heat like repeat family member 8
chr1_-_169711603 0.08 ENST00000236147.6
ENST00000650983.1
SELL
selectin L
chr2_+_127645864 0.07 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr19_-_41428730 0.07 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr1_-_205422050 0.05 ENST00000367153.9
LEMD1
LEM domain containing 1
chrX_+_55623400 0.05 ENST00000339140.5
FOXR2
forkhead box R2
chr12_-_118359639 0.05 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr1_+_62597510 0.04 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr12_+_56763316 0.03 ENST00000322165.1
HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
chr7_+_129368123 0.02 ENST00000460109.5
ENST00000474594.5
AHCYL2
adenosylhomocysteinase like 2
chr2_+_112977998 0.02 ENST00000259205.5
ENST00000376489.6
IL36G
interleukin 36 gamma
chr8_+_109086585 0.00 ENST00000518632.2
TRHR
thyrotropin releasing hormone receptor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0002282 microglial cell activation involved in immune response(GO:0002282) macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518)
0.4 1.2 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.4 2.5 GO:0097338 response to clozapine(GO:0097338)
0.2 0.7 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 1.4 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 0.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.3 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.4 GO:0099738 cell cortex region(GO:0099738)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.2 2.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.3 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 1.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 2.5 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 2.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling