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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HIC2
Z-value: 1.19
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Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg38_v1_chr22_+_21417357_21417379 | -0.53 | 7.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.0 | GO:0051040 | regulation of calcium-independent cell-cell adhesion(GO:0051040) |
| 0.3 | 5.7 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.2 | 4.8 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.9 | 4.6 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.9 | 3.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 3.4 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 1.1 | 3.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.1 | 3.2 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.0 | 3.1 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.9 | 2.7 | GO:0034148 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.5 | 3.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.4 | 3.2 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 2.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 2.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 2.4 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.7 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.7 | 5.7 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.0 | 4.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 4.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 3.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.3 | 3.5 | GO:0019958 | C-X-C chemokine binding(GO:0019958) |
| 0.4 | 3.2 | GO:0023029 | peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029) TAP2 binding(GO:0046979) |
| 0.2 | 2.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 2.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.6 | 2.6 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 6.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 4.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 4.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 2.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 2.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 2.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 5.8 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 4.6 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.3 | 4.2 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 3.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 3.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |