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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HIF1A
Z-value: 0.77
Motif logo
Transcription factors associated with HIF1A
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HIF1A
|
ENSG00000100644.17 | HIF1A |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIF1A | hg38_v1_chr14_+_61695435_61695598, hg38_v1_chr14_+_61697622_61697717, hg38_v1_chr14_+_61695777_61695813 | -0.42 | 3.7e-02 | Click! |
Activity profile of HIF1A motif
Sorted Z-values of HIF1A motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HIF1A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 1.2 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.2 | 0.7 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 0.2 | 0.6 | GO:0034395 | regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) |
| 0.2 | 0.5 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.2 | 0.5 | GO:0035570 | N-terminal protein amino acid methylation(GO:0006480) N-terminal peptidyl-alanine methylation(GO:0018011) N-terminal peptidyl-alanine trimethylation(GO:0018012) N-terminal peptidyl-glycine methylation(GO:0018013) N-terminal peptidyl-proline dimethylation(GO:0018016) peptidyl-alanine modification(GO:0018194) N-terminal peptidyl-proline methylation(GO:0035568) N-terminal peptidyl-serine methylation(GO:0035570) N-terminal peptidyl-serine dimethylation(GO:0035572) N-terminal peptidyl-serine trimethylation(GO:0035573) |
| 0.2 | 0.8 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.2 | 1.0 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.2 | 1.7 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.1 | 0.6 | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 0.1 | 1.7 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 0.5 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 0.1 | 0.5 | GO:0042450 | arginine biosynthetic process via ornithine(GO:0042450) |
| 0.1 | 1.3 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 0.5 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.1 | 0.5 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.1 | 0.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.3 | GO:1990569 | UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569) |
| 0.1 | 0.3 | GO:0061182 | negative regulation of chondrocyte development(GO:0061182) |
| 0.1 | 0.5 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.1 | 0.4 | GO:0051792 | medium-chain fatty acid biosynthetic process(GO:0051792) |
| 0.1 | 0.4 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.1 | 1.5 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.1 | 0.2 | GO:0070078 | peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine(GO:0018395) histone arginine demethylation(GO:0070077) histone H3-R2 demethylation(GO:0070078) histone H4-R3 demethylation(GO:0070079) |
| 0.1 | 0.2 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.1 | 0.6 | GO:0097411 | hypoxia-inducible factor-1alpha signaling pathway(GO:0097411) |
| 0.1 | 0.4 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.1 | 0.2 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.1 | 0.4 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.1 | 1.3 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.1 | 0.3 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.1 | 0.2 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 0.1 | 0.4 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 0.5 | GO:1902731 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 0.1 | 0.3 | GO:0006175 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) |
| 0.1 | 0.4 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.1 | 0.1 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.1 | 0.3 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.1 | 0.6 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 0.2 | GO:0035281 | pre-miRNA export from nucleus(GO:0035281) |
| 0.1 | 0.5 | GO:1904628 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.1 | 0.4 | GO:2000969 | positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
| 0.1 | 0.1 | GO:1905071 | occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075) |
| 0.1 | 0.1 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
| 0.1 | 0.5 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 1.2 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.0 | 0.2 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.0 | 0.6 | GO:0038129 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.0 | 0.6 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 0.2 | GO:0000466 | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466) |
| 0.0 | 0.4 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.0 | 0.3 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 0.0 | 0.2 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 0.0 | 0.2 | GO:0043418 | cysteine biosynthetic process from serine(GO:0006535) cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) homocysteine catabolic process(GO:0043418) L-cysteine metabolic process(GO:0046439) |
| 0.0 | 0.7 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.0 | 0.2 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.0 | 0.5 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.2 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.0 | 1.5 | GO:0006706 | steroid catabolic process(GO:0006706) |
| 0.0 | 0.4 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.0 | 0.2 | GO:1904398 | positive regulation of neuromuscular junction development(GO:1904398) |
| 0.0 | 0.1 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.0 | 0.4 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.0 | 0.9 | GO:0000469 | cleavage involved in rRNA processing(GO:0000469) |
| 0.0 | 0.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.5 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.4 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.3 | GO:0017062 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.0 | 0.4 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.5 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.0 | 0.2 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.0 | 0.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.0 | 0.1 | GO:0043321 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.0 | 0.2 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.0 | 0.1 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.0 | 0.2 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.3 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.0 | 0.4 | GO:0001553 | luteinization(GO:0001553) |
| 0.0 | 0.8 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 0.1 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 1.0 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.0 | 1.2 | GO:0030201 | heparan sulfate proteoglycan metabolic process(GO:0030201) |
| 0.0 | 0.4 | GO:0009125 | nucleoside monophosphate catabolic process(GO:0009125) |
| 0.0 | 1.1 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.1 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 0.0 | 0.2 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.0 | 0.1 | GO:1904799 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 0.0 | 0.1 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.0 | 0.2 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.1 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 0.0 | 0.7 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.2 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.0 | 0.1 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 0.0 | 0.3 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.0 | 0.2 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.0 | 0.1 | GO:0060748 | tertiary branching involved in mammary gland duct morphogenesis(GO:0060748) |
| 0.0 | 0.2 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 0.4 | GO:0031935 | regulation of chromatin silencing(GO:0031935) |
| 0.0 | 0.6 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.0 | 0.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.1 | GO:0002905 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.0 | 0.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.4 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.1 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.0 | 0.0 | GO:0002368 | B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.0 | 0.1 | GO:0043587 | tongue morphogenesis(GO:0043587) |
| 0.0 | 0.2 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 0.3 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.0 | 0.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.4 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 0.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:1905202 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202) |
| 0.1 | 1.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.5 | GO:0005960 | glycine cleavage complex(GO:0005960) |
| 0.1 | 0.6 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.1 | 0.3 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 0.5 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 1.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.3 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 0.3 | GO:0044308 | axonal spine(GO:0044308) |
| 0.1 | 0.2 | GO:0042565 | RNA nuclear export complex(GO:0042565) |
| 0.1 | 0.7 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.1 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.0 | 0.4 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.4 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 3.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.4 | GO:0070449 | elongin complex(GO:0070449) |
| 0.0 | 0.9 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.1 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.0 | 0.6 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 1.1 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.1 | GO:0034455 | t-UTP complex(GO:0034455) |
| 0.0 | 0.1 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.0 | 0.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.2 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 1.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.1 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.0 | 0.1 | GO:0071547 | piP-body(GO:0071547) |
| 0.0 | 0.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.1 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 1.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.1 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.1 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.4 | 1.5 | GO:0004773 | steryl-sulfatase activity(GO:0004773) |
| 0.3 | 1.7 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.3 | 1.2 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 0.2 | 0.7 | GO:0070364 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 0.2 | 1.7 | GO:0004485 | methylcrotonoyl-CoA carboxylase activity(GO:0004485) |
| 0.2 | 1.2 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.2 | 0.8 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 0.2 | 1.0 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.2 | 0.7 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.2 | 0.5 | GO:0004056 | argininosuccinate lyase activity(GO:0004056) |
| 0.2 | 0.5 | GO:0071885 | N-terminal protein N-methyltransferase activity(GO:0071885) |
| 0.2 | 0.5 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.1 | 0.4 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.1 | 1.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 0.5 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 0.6 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 0.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 0.6 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 0.3 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
| 0.1 | 0.3 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.1 | 0.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.1 | 0.7 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 0.2 | GO:0033749 | histone demethylase activity (H3-R2 specific)(GO:0033746) histone demethylase activity (H4-R3 specific)(GO:0033749) |
| 0.1 | 0.3 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.1 | 0.5 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 0.4 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 0.3 | GO:0015094 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 0.5 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 0.3 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.1 | 1.1 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 0.2 | GO:0070025 | oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 0.1 | 0.2 | GO:0090631 | pre-miRNA transporter activity(GO:0090631) |
| 0.1 | 0.4 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.1 | GO:0035605 | peptidyl-cysteine S-nitrosylase activity(GO:0035605) |
| 0.0 | 0.6 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.5 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.5 | GO:0015288 | porin activity(GO:0015288) |
| 0.0 | 0.1 | GO:0008900 | hydrogen:potassium-exchanging ATPase activity(GO:0008900) |
| 0.0 | 0.5 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.2 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 0.0 | 0.2 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.0 | 0.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 0.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 0.7 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 0.2 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.2 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.0 | 0.6 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.2 | GO:0051998 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.0 | 0.4 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 1.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.4 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.2 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 0.2 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.0 | 0.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.1 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.0 | 1.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.1 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.0 | 0.2 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.4 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.4 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.0 | 0.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.1 | GO:0009383 | rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) |
| 0.0 | 0.2 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 0.1 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.0 | 0.0 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.0 | 0.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 2.5 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.5 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 0.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.2 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.0 | 0.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 0.1 | GO:0008312 | 7S RNA binding(GO:0008312) |
| 0.0 | 0.1 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.0 | 0.1 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.0 | 0.1 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.9 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 3.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.6 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.4 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.5 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 0.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.4 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.6 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 2.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.6 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.4 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 1.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.6 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.4 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.2 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.5 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 0.7 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.0 | 0.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |