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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HIVEP1
Z-value: 1.74
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Transcription factors associated with HIVEP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIVEP1 | hg38_v1_chr6_+_12012304_12012338 | 0.44 | 2.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIVEP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76023489 Show fit | 12.09 |
ENST00000306602.3
|
C-X-C motif chemokine ligand 10 |
|
| chr4_+_73836667 Show fit | 11.00 |
ENST00000226317.10
|
C-X-C motif chemokine ligand 6 |
|
| chr17_+_42288429 Show fit | 8.53 |
ENST00000676631.1
ENST00000677893.1 |
signal transducer and activator of transcription 5A |
|
| chr17_+_42288464 Show fit | 8.51 |
ENST00000590726.7
ENST00000678903.1 ENST00000590949.6 ENST00000676585.1 ENST00000588868.5 |
signal transducer and activator of transcription 5A |
|
| chr19_+_4229502 Show fit | 8.03 |
ENST00000221847.6
|
Epstein-Barr virus induced 3 |
|
| chr9_-_120929160 Show fit | 7.98 |
ENST00000540010.1
|
TNF receptor associated factor 1 |
|
| chr6_+_14117764 Show fit | 7.89 |
ENST00000379153.4
|
CD83 molecule |
|
| chr4_-_73998669 Show fit | 7.87 |
ENST00000296027.5
|
C-X-C motif chemokine ligand 5 |
|
| chr19_+_45001430 Show fit | 6.94 |
ENST00000625761.2
ENST00000505236.1 ENST00000221452.13 |
RELB proto-oncogene, NF-kB subunit |
|
| chr1_-_7940825 Show fit | 6.72 |
ENST00000377507.8
|
TNF receptor superfamily member 9 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 20.6 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.2 | 17.9 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 2.4 | 17.0 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 1.5 | 15.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 1.1 | 11.7 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.7 | 9.1 | GO:0032782 | bile acid secretion(GO:0032782) |
| 1.6 | 8.1 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.1 | 8.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.9 | 8.0 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.5 | 8.0 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.4 | 15.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 12.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.6 | 8.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 7.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 6.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 5.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 1.8 | 5.4 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.2 | 5.3 | GO:0000145 | exocyst(GO:0000145) |
| 0.6 | 5.2 | GO:0043196 | varicosity(GO:0043196) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 20.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.4 | 12.8 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.4 | 12.5 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 2.4 | 12.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 10.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.7 | 9.4 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.5 | 9.2 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 8.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.2 | 7.4 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.2 | 6.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 19.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 17.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.3 | 15.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.2 | 13.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.3 | 9.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 9.2 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.3 | 9.0 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.2 | 7.9 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 6.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 34.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.9 | 18.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 1.4 | 15.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 11.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.4 | 9.3 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 7.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 6.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.2 | 4.9 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 4.6 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 4.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |