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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HLF_TEF
Z-value: 0.92
Motif logo
Transcription factors associated with HLF_TEF
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HLF
|
ENSG00000108924.14 | HLF |
|
TEF
|
ENSG00000167074.15 | TEF |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLF | hg38_v1_chr17_+_55266216_55266227 | 0.33 | 1.1e-01 | Click! |
| TEF | hg38_v1_chr22_+_41367269_41367333, hg38_v1_chr22_+_41381923_41381968 | -0.03 | 8.8e-01 | Click! |
Activity profile of HLF_TEF motif
Sorted Z-values of HLF_TEF motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HLF_TEF
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.1 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.5 | 2.8 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.4 | 1.2 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.4 | 2.2 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.3 | 1.3 | GO:0009443 | pyridoxal 5'-phosphate salvage(GO:0009443) |
| 0.3 | 2.0 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.2 | 1.0 | GO:1902159 | regulation of cyclic nucleotide-gated ion channel activity(GO:1902159) |
| 0.2 | 2.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 0.5 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 0.1 | 0.6 | GO:0000451 | rRNA 2'-O-methylation(GO:0000451) |
| 0.1 | 1.5 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.1 | 2.2 | GO:0045657 | positive regulation of monocyte differentiation(GO:0045657) |
| 0.1 | 0.4 | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) |
| 0.1 | 0.3 | GO:0048058 | compound eye corneal lens development(GO:0048058) |
| 0.1 | 0.9 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.1 | 0.4 | GO:0090467 | L-arginine import(GO:0043091) arginine import(GO:0090467) |
| 0.1 | 0.4 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 0.7 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.1 | 1.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 0.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 0.8 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052) |
| 0.1 | 1.4 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.1 | 0.6 | GO:1904628 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.1 | 0.8 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.1 | 0.3 | GO:0046271 | phenylpropanoid catabolic process(GO:0046271) |
| 0.1 | 1.0 | GO:0046549 | photoreceptor cell outer segment organization(GO:0035845) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.1 | 0.3 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.1 | 0.6 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 0.2 | GO:0046136 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.1 | 0.8 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 9.1 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.1 | 0.2 | GO:1903015 | regulation of exo-alpha-sialidase activity(GO:1903015) |
| 0.1 | 0.2 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.1 | 0.6 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 0.3 | GO:0009804 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.1 | 0.3 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 1.1 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.1 | 0.3 | GO:1904640 | response to methionine(GO:1904640) |
| 0.1 | 0.4 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 0.4 | GO:0031627 | telomeric loop formation(GO:0031627) |
| 0.1 | 0.6 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.1 | 0.5 | GO:0051106 | single strand break repair(GO:0000012) positive regulation of DNA ligation(GO:0051106) |
| 0.1 | 0.2 | GO:1903567 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.1 | 2.7 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 0.6 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 1.0 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.1 | 0.2 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.0 | 0.5 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.0 | 0.4 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.2 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.0 | 0.1 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.0 | 0.1 | GO:0001983 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) |
| 0.0 | 0.3 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.0 | 1.5 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 0.2 | GO:0030952 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952) |
| 0.0 | 0.2 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.0 | 0.4 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.0 | 0.6 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.7 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.0 | 0.2 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.0 | 0.5 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.0 | 0.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 0.2 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.0 | 1.4 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.1 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.0 | 0.1 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.0 | 1.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.6 | GO:0031065 | positive regulation of histone deacetylation(GO:0031065) |
| 0.0 | 0.2 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.0 | 0.5 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.0 | 0.2 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.0 | 0.1 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.0 | 0.2 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.0 | 0.3 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 7.3 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.0 | 0.5 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.0 | 0.8 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.0 | 0.1 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.0 | 0.7 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.0 | 0.3 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 0.2 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.0 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.0 | 0.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 0.1 | GO:0006983 | ER overload response(GO:0006983) |
| 0.0 | 0.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 0.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.3 | 2.0 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.3 | 2.8 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.2 | 2.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 0.6 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.1 | 1.4 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 9.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 0.8 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.1 | 12.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.2 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.4 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.5 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 1.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.3 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.4 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.0 | 0.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.8 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.1 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 0.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 2.2 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 0.0 | GO:0030849 | autosome(GO:0030849) |
| 0.0 | 3.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.1 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.5 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.1 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.5 | 2.8 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.4 | 9.0 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.3 | 1.3 | GO:0008478 | pyridoxal kinase activity(GO:0008478) |
| 0.3 | 2.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.3 | 1.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 0.6 | GO:0070039 | rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039) |
| 0.2 | 0.6 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.2 | 1.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 1.4 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.1 | 0.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 0.7 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 0.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 1.8 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 1.0 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 0.4 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.1 | 0.4 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 0.1 | 0.4 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 1.0 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 0.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 2.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.4 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 0.2 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
| 0.1 | 1.0 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.1 | 0.2 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.1 | 1.0 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 0.3 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.0 | 0.2 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.0 | 0.5 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.4 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.0 | 0.2 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.0 | 0.3 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.0 | 0.6 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.4 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 0.2 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.0 | 0.5 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 0.3 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.1 | GO:0031716 | calcitonin receptor binding(GO:0031716) |
| 0.0 | 0.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.1 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.0 | 0.4 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 0.8 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.3 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 0.1 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.0 | 0.1 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.0 | 0.5 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.0 | 0.1 | GO:0004122 | cystathionine beta-synthase activity(GO:0004122) |
| 0.0 | 0.2 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.0 | 0.1 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
| 0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.1 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.0 | 11.5 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.2 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.0 | 0.2 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.1 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.0 | 5.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.5 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.1 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 0.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 2.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 8.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 1.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.4 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 1.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.8 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 2.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.4 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.5 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 2.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 2.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 9.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.8 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.6 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.3 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 1.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.6 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.5 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 2.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 0.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |