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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HMGA1
Z-value: 1.58
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Transcription factors associated with HMGA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA1 | hg38_v1_chr6_+_34236865_34236887 | -0.52 | 7.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.8 | 13.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.3 | 13.2 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 9.4 | GO:0007286 | spermatid development(GO:0007286) |
| 2.3 | 9.2 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 1.3 | 8.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.0 | 8.3 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 8.2 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 1.3 | 7.7 | GO:0060023 | soft palate development(GO:0060023) |
| 1.3 | 7.7 | GO:1903284 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 12.9 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.3 | 12.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 10.2 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.1 | 8.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.4 | 8.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 7.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 7.5 | GO:0005819 | spindle(GO:0005819) |
| 0.2 | 7.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 7.3 | GO:0071564 | npBAF complex(GO:0071564) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 17.2 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 16.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.5 | 14.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 8.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 8.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 7.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 1.3 | 7.7 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 7.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 6.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 12.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 8.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 8.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 7.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 7.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 5.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 4.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.2 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.3 | 11.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 10.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 10.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 8.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 7.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 6.3 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 6.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 5.1 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 5.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |