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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HMGA2

Z-value: 0.41

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.14 HMGA2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg38_v1_chr12_+_65825116_65825134-0.395.2e-02Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_75932392 1.30 ENST00000284142.7
ASB17
ankyrin repeat and SOCS box containing 17
chr13_+_50909905 0.74 ENST00000644034.1
ENST00000645955.1
RNASEH2B
ribonuclease H2 subunit B
chr9_+_2157647 0.68 ENST00000452193.5
ENST00000324954.10
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_85888685 0.64 ENST00000638178.1
ENST00000640982.1
ENST00000640992.1
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr15_-_70702273 0.59 ENST00000558758.5
ENST00000379983.6
ENST00000560441.5
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_1413456 0.55 ENST00000539820.5
ENST00000382269.7
ENST00000345913.8
ENST00000329066.9
ENST00000382201.7
TPO
thyroid peroxidase
chr2_-_182522703 0.45 ENST00000410103.1
PDE1A
phosphodiesterase 1A
chr1_+_248013660 0.40 ENST00000355281.2
OR2L5
olfactory receptor family 2 subfamily L member 5
chr20_-_1491407 0.39 ENST00000359801.8
SIRPB2
signal regulatory protein beta 2
chr1_+_196652022 0.35 ENST00000367429.9
ENST00000630130.2
ENST00000359637.2
CFH
complement factor H
chr19_+_41376560 0.35 ENST00000436170.6
TMEM91
transmembrane protein 91
chr2_+_234978685 0.35 ENST00000409212.5
ENST00000344528.8
ENST00000444916.5
SH3BP4
SH3 domain binding protein 4
chr15_+_84235773 0.35 ENST00000510439.7
ENST00000422563.6
GOLGA6L4
golgin A6 family like 4
chr15_-_82349437 0.35 ENST00000621197.4
ENST00000610657.2
ENST00000619556.4
GOLGA6L10
golgin A6 family like 10
chr14_+_88385714 0.34 ENST00000045347.11
SPATA7
spermatogenesis associated 7
chr15_+_30604028 0.33 ENST00000566740.2
GOLGA8H
golgin A8 family member H
chr10_+_35167516 0.31 ENST00000361599.8
CREM
cAMP responsive element modulator
chr10_-_99913971 0.31 ENST00000543621.6
DNMBP
dynamin binding protein
chr7_+_80638662 0.31 ENST00000394788.7
CD36
CD36 molecule
chr15_-_32455634 0.30 ENST00000509311.7
GOLGA8O
golgin A8 family member O
chr7_+_80638510 0.30 ENST00000433696.6
ENST00000538969.5
ENST00000544133.5
CD36
CD36 molecule
chr2_+_169827432 0.27 ENST00000272793.11
UBR3
ubiquitin protein ligase E3 component n-recognin 3
chr2_-_55334529 0.27 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
CCDC88A
coiled-coil domain containing 88A
chr12_+_113149708 0.27 ENST00000335621.11
CFAP73
cilia and flagella associated protein 73
chr19_-_37655409 0.26 ENST00000591444.1
ENST00000351218.6
ENST00000684514.1
ENST00000587809.5
ZFP30
ZFP30 zinc finger protein
chr17_-_27893339 0.25 ENST00000460380.6
ENST00000379102.8
ENST00000508862.5
ENST00000582441.1
LYRM9
ENSG00000266202.1
LYR motif containing 9
novel protein
chr10_-_5003850 0.25 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
AKR1C2
aldo-keto reductase family 1 member C2
chr17_-_445939 0.24 ENST00000329099.4
RFLNB
refilin B
chr7_+_120950763 0.23 ENST00000339121.9
ENST00000315870.10
ENST00000445699.5
ING3
inhibitor of growth family member 3
chr20_+_56392607 0.23 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr13_+_50909745 0.20 ENST00000422660.6
ENST00000645188.1
ENST00000646731.1
ENST00000643774.1
ENST00000646960.1
ENST00000637648.2
ENST00000336617.8
RNASEH2B
ribonuclease H2 subunit B
chr2_-_89143133 0.20 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr19_+_41376692 0.20 ENST00000447302.6
ENST00000544232.5
ENST00000542945.5
ENST00000540732.3
TMEM91
ENSG00000255730.5
transmembrane protein 91
novel protein
chr2_-_182522556 0.20 ENST00000435564.5
PDE1A
phosphodiesterase 1A
chr15_+_58410543 0.19 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr21_+_37420299 0.19 ENST00000455097.6
ENST00000643854.1
ENST00000645424.1
ENST00000642309.1
ENST00000645774.1
ENST00000398956.2
DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
chr7_+_80638633 0.19 ENST00000447544.7
ENST00000482059.6
CD36
CD36 molecule
chr3_-_157503375 0.19 ENST00000362010.7
VEPH1
ventricular zone expressed PH domain containing 1
chr3_-_157503339 0.19 ENST00000392833.6
VEPH1
ventricular zone expressed PH domain containing 1
chr9_-_34729482 0.18 ENST00000378788.4
FAM205A
family with sequence similarity 205 member A
chr1_-_21113129 0.17 ENST00000684485.1
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr7_+_64207090 0.17 ENST00000429565.4
ZNF735
zinc finger protein 735
chrX_-_154295085 0.16 ENST00000617225.4
ENST00000619903.4
TEX28
testis expressed 28
chr2_+_171687457 0.16 ENST00000397119.8
ENST00000410079.7
ENST00000438879.5
DYNC1I2
dynein cytoplasmic 1 intermediate chain 2
chr12_-_10172117 0.15 ENST00000545927.5
ENST00000309539.8
ENST00000432556.6
ENST00000544577.5
OLR1
oxidized low density lipoprotein receptor 1
chr11_-_130916437 0.15 ENST00000533214.1
ENST00000528555.5
ENST00000530356.5
ENST00000265909.9
SNX19
sorting nexin 19
chr22_-_18936142 0.15 ENST00000438924.5
ENST00000457083.1
ENST00000357068.11
ENST00000420436.5
ENST00000334029.6
ENST00000610940.4
PRODH
proline dehydrogenase 1
chr18_-_14132423 0.14 ENST00000589498.5
ENST00000590202.3
ZNF519
zinc finger protein 519
chr12_-_8612850 0.13 ENST00000229335.11
ENST00000537228.5
AICDA
activation induced cytidine deaminase
chr19_+_41376499 0.13 ENST00000392002.7
TMEM91
transmembrane protein 91
chrX_-_136880715 0.12 ENST00000431446.7
ENST00000320676.11
ENST00000562646.5
RBMX
RNA binding motif protein X-linked
chr2_-_215393126 0.12 ENST00000456923.5
FN1
fibronectin 1
chr19_-_10565990 0.12 ENST00000539027.5
ENST00000312962.12
ENST00000543682.3
ENST00000652042.1
ENST00000432197.5
KRI1
KRI1 homolog
chr1_+_196977550 0.11 ENST00000256785.5
CFHR5
complement factor H related 5
chr6_+_111259294 0.10 ENST00000672303.1
ENST00000671876.2
ENST00000368847.5
MFSD4B
major facilitator superfamily domain containing 4B
chr11_+_94567362 0.10 ENST00000299001.11
PIWIL4
piwi like RNA-mediated gene silencing 4
chr6_-_127343590 0.09 ENST00000368291.6
ENST00000454859.8
ECHDC1
ethylmalonyl-CoA decarboxylase 1
chr14_-_94293024 0.09 ENST00000393096.5
SERPINA10
serpin family A member 10
chr14_-_94293260 0.09 ENST00000261994.9
SERPINA10
serpin family A member 10
chr1_+_227563528 0.09 ENST00000608949.5
ENST00000343776.10
ZNF678
zinc finger protein 678
chrX_-_7927375 0.08 ENST00000381042.9
PNPLA4
patatin like phospholipase domain containing 4
chr3_+_186783567 0.08 ENST00000323963.10
ENST00000440191.6
EIF4A2
eukaryotic translation initiation factor 4A2
chr21_-_30480364 0.08 ENST00000390689.3
KRTAP19-1
keratin associated protein 19-1
chr6_-_127343518 0.08 ENST00000528402.5
ENST00000454591.6
ECHDC1
ethylmalonyl-CoA decarboxylase 1
chr14_-_94293071 0.08 ENST00000554723.5
SERPINA10
serpin family A member 10
chr10_-_127892930 0.07 ENST00000368671.4
CLRN3
clarin 3
chrX_-_7927701 0.07 ENST00000537427.5
ENST00000444736.5
ENST00000442940.1
PNPLA4
patatin like phospholipase domain containing 4
chr11_+_67483019 0.07 ENST00000279146.8
ENST00000528641.7
ENST00000682324.1
ENST00000684006.1
ENST00000683237.1
ENST00000684657.1
AIP
aryl hydrocarbon receptor interacting protein
chr5_-_103120097 0.07 ENST00000508629.5
ENST00000399004.7
GIN1
gypsy retrotransposon integrase 1
chr3_+_98166696 0.06 ENST00000641450.1
OR5H15
olfactory receptor family 5 subfamily H member 15
chr19_-_42594918 0.06 ENST00000244336.10
CEACAM8
CEA cell adhesion molecule 8
chr8_-_54101458 0.06 ENST00000521352.5
ENST00000618741.1
LYPLA1
lysophospholipase 1
chr12_-_122266410 0.06 ENST00000451053.3
VPS33A
VPS33A core subunit of CORVET and HOPS complexes
chr2_+_119679184 0.06 ENST00000445518.1
ENST00000272521.7
ENST00000409951.1
TMEM177
transmembrane protein 177
chr19_+_11346499 0.05 ENST00000458408.6
ENST00000586451.5
ENST00000588592.5
CCDC159
coiled-coil domain containing 159
chr14_-_68979314 0.05 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
ACTN1
actinin alpha 1
chr18_-_23437927 0.05 ENST00000578520.5
ENST00000383233.8
TMEM241
transmembrane protein 241
chrX_+_118346072 0.05 ENST00000371822.9
ENST00000254029.8
ENST00000371825.7
WDR44
WD repeat domain 44
chr1_-_247536440 0.05 ENST00000366487.4
ENST00000641802.1
OR2C3
olfactory receptor family 2 subfamily C member 3
chr2_+_119679154 0.03 ENST00000401466.5
ENST00000424086.5
TMEM177
transmembrane protein 177
chr6_+_116571477 0.02 ENST00000487832.6
ENST00000466444.7
ENST00000518117.5
RWDD1
RWD domain containing 1
chr7_-_103344588 0.02 ENST00000426036.6
ENST00000249270.11
ENST00000379263.8
ENST00000454277.5
ENST00000412522.1
DNAJC2
DnaJ heat shock protein family (Hsp40) member C2
chr17_-_4704040 0.01 ENST00000570571.5
ENST00000575101.1
ENST00000574876.5
ENST00000572293.7
PELP1
proline, glutamate and leucine rich protein 1
chr11_+_60492775 0.01 ENST00000526784.5
ENST00000537076.5
ENST00000016913.8
ENST00000530007.1
MS4A12
membrane spanning 4-domains A12
chr4_+_78551733 0.01 ENST00000512884.5
ENST00000512542.5
ENST00000503570.6
ENST00000264908.11
ANXA3
annexin A3
chr1_+_197917355 0.00 ENST00000367388.4
ENST00000367387.6
LHX9
LIM homeobox 9
chr7_-_57132425 0.00 ENST00000319636.10
ZNF479
zinc finger protein 479

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:2000334 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.2 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.6 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.3 GO:0097545 axonemal outer doublet(GO:0097545)
0.1 0.2 GO:0071756 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0047291 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.1 0.6 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.8 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.2 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.2 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.0 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects