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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HNF4A

Z-value: 0.91

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Transcription factors associated with HNF4A

Gene Symbol Gene ID Gene Info
ENSG00000101076.18 HNF4A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF4Ahg38_v1_chr20_+_44401269_444013010.252.3e-01Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_78045956 4.08 ENST00000370759.4
GIPC PDZ domain containing family member 2
chr1_+_61082398 3.81 ENST00000664149.1
nuclear factor I A
chr12_-_94616061 3.48 ENST00000551457.1
transmembrane and coiled-coil domain family 3
chr1_+_61082553 3.29 ENST00000403491.8
ENST00000371187.7
nuclear factor I A
chr1_+_61082702 3.12 ENST00000485903.6
ENST00000371185.6
ENST00000371184.6
nuclear factor I A
chr2_-_221572272 2.12 ENST00000409854.5
ENST00000443796.5
ENST00000281821.7
EPH receptor A4
chr14_+_38207893 1.84 ENST00000267377.3
somatostatin receptor 1
chrX_+_118974608 1.55 ENST00000304778.11
ENST00000371628.8
LON peptidase N-terminal domain and ring finger 3
chr17_+_63477052 1.55 ENST00000290866.10
ENST00000428043.5
angiotensin I converting enzyme
chr17_-_7179544 1.55 ENST00000619926.4
asialoglycoprotein receptor 1
chr10_-_17129786 1.53 ENST00000377833.10
cubilin
chr20_+_64063481 1.50 ENST00000415602.5
transcription elongation factor A2
chr18_+_32190015 1.50 ENST00000581447.1
meprin A subunit beta
chr2_+_190927649 1.49 ENST00000409428.5
ENST00000409215.5
glutaminase
chr10_-_114684612 1.48 ENST00000533213.6
ENST00000369252.8
actin binding LIM protein 1
chr18_+_32190033 1.48 ENST00000269202.11
meprin A subunit beta
chr8_-_17002327 1.38 ENST00000180166.6
fibroblast growth factor 20
chr19_-_48363914 1.36 ENST00000377431.6
ENST00000293261.8
transmembrane protein 143
chr6_+_30914205 1.35 ENST00000672801.1
ENST00000321897.9
ENST00000625423.2
ENST00000676266.1
ENST00000428017.5
valyl-tRNA synthetase 2, mitochondrial
chr17_-_7179348 1.29 ENST00000573083.1
ENST00000574388.5
ENST00000269299.8
asialoglycoprotein receptor 1
chr11_-_63229652 1.25 ENST00000306494.10
solute carrier family 22 member 25
chr6_+_30914329 1.24 ENST00000541562.6
valyl-tRNA synthetase 2, mitochondrial
chr19_-_48364034 1.21 ENST00000435956.7
transmembrane protein 143
chr13_-_52011337 1.15 ENST00000400366.6
ENST00000400370.8
ENST00000634844.1
ENST00000673772.1
ENST00000418097.7
ENST00000242839.10
ENST00000344297.9
ENST00000448424.7
ATPase copper transporting beta
chr1_+_204073104 1.15 ENST00000367204.6
SRY-box transcription factor 13
chr6_+_143677935 1.09 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
phosphatase and actin regulator 2
chr3_+_50269140 1.07 ENST00000616701.5
ENST00000433753.4
ENST00000611067.4
semaphorin 3B
chr14_+_64214136 1.06 ENST00000557084.1
ENST00000458046.6
spectrin repeat containing nuclear envelope protein 2
chr6_-_31897200 1.00 ENST00000395728.7
ENST00000375528.8
euchromatic histone lysine methyltransferase 2
chr16_+_8674605 0.97 ENST00000268251.13
4-aminobutyrate aminotransferase
chr8_+_95024977 0.95 ENST00000396124.9
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr5_-_42811884 0.93 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
selenoprotein P
chr3_-_126056786 0.90 ENST00000383598.6
solute carrier family 41 member 3
chr2_+_158456939 0.88 ENST00000389759.8
ENST00000628904.2
ENST00000389757.7
plakophilin 4
chr1_+_94418375 0.88 ENST00000370214.9
ATP binding cassette subfamily D member 3
chr1_+_28369705 0.83 ENST00000373839.8
phosphatase and actin regulator 4
chr12_-_6556034 0.83 ENST00000619571.5
ENST00000336604.8
ENST00000396840.6
ENST00000356896.8
intermediate filament family orphan 1
chr1_+_94418435 0.81 ENST00000647998.2
ATP binding cassette subfamily D member 3
chr1_+_94418467 0.79 ENST00000315713.5
ATP binding cassette subfamily D member 3
chr20_+_64063105 0.78 ENST00000395053.7
ENST00000343484.10
ENST00000339217.8
transcription elongation factor A2
chr20_-_37527723 0.77 ENST00000397135.1
ENST00000397137.5
BLCAP apoptosis inducing factor
chr15_-_56245074 0.74 ENST00000674082.1
regulatory factor X7
chr1_+_20633450 0.74 ENST00000321556.5
PTEN induced kinase 1
chr13_+_113122791 0.71 ENST00000375559.8
ENST00000409306.5
ENST00000375551.7
coagulation factor X
chr11_+_118998126 0.71 ENST00000334418.6
centrosomal AT-AC splicing factor
chr19_-_14062028 0.68 ENST00000669674.2
paralemmin 3
chr19_-_14090963 0.67 ENST00000269724.5
sterile alpha motif domain containing 1
chr19_-_15125095 0.67 ENST00000600984.5
ilvB acetolactate synthase like
chr22_+_19962537 0.66 ENST00000449653.5
catechol-O-methyltransferase
chr2_+_218270392 0.65 ENST00000248451.7
ENST00000273077.9
PNKD metallo-beta-lactamase domain containing
chr8_+_22579100 0.65 ENST00000452226.5
ENST00000397760.8
PDZ and LIM domain 2
chr13_+_113105782 0.65 ENST00000541084.5
ENST00000346342.8
ENST00000375581.3
coagulation factor VII
chr3_-_49813880 0.65 ENST00000333486.4
ubiquitin like modifier activating enzyme 7
chr12_-_53727476 0.64 ENST00000549784.5
ENST00000262059.8
calcium binding and coiled-coil domain 1
chr9_-_113303271 0.63 ENST00000297894.5
ENST00000489339.2
ring finger protein 183
chr8_+_22579139 0.63 ENST00000397761.6
PDZ and LIM domain 2
chr7_-_15561986 0.63 ENST00000342526.8
alkylglycerol monooxygenase
chr10_-_102120246 0.62 ENST00000425280.2
LIM domain binding 1
chr12_-_108826161 0.62 ENST00000546697.1
slingshot protein phosphatase 1
chr6_-_30113086 0.62 ENST00000376734.4
tripartite motif containing 31
chr12_-_53727428 0.61 ENST00000548263.5
ENST00000430117.6
ENST00000549173.5
ENST00000550804.6
ENST00000551900.5
ENST00000546619.5
ENST00000548177.5
ENST00000549349.5
calcium binding and coiled-coil domain 1
chr20_-_37527862 0.60 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP apoptosis inducing factor
chr17_+_28744034 0.59 ENST00000444415.7
ENST00000262396.10
TNF receptor associated factor 4
chr8_+_11808417 0.52 ENST00000525954.5
farnesyl-diphosphate farnesyltransferase 1
chr2_-_62506136 0.52 ENST00000335390.6
transmembrane protein 17
chr2_+_172860038 0.51 ENST00000538974.5
ENST00000540783.5
Rap guanine nucleotide exchange factor 4
chr10_+_100347225 0.51 ENST00000370355.3
stearoyl-CoA desaturase
chr22_+_29767351 0.51 ENST00000330029.6
ENST00000401406.3
ubiquinol-cytochrome c reductase, complex III subunit X
chr1_-_50023875 0.51 ENST00000371836.1
ENST00000371838.5
ATP/GTP binding protein like 4
chr10_+_102644462 0.50 ENST00000643721.2
ENST00000302424.12
tripartite motif containing 8
chr17_+_75610690 0.50 ENST00000642007.1
myosin XVB
chr17_+_29043124 0.48 ENST00000323372.9
pipecolic acid and sarcosine oxidase
chr8_+_69492793 0.48 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
sulfatase 1
chr9_+_27109200 0.47 ENST00000380036.10
TEK receptor tyrosine kinase
chr17_-_29176752 0.47 ENST00000533112.5
myosin XVIIIA
chrX_-_154412083 0.46 ENST00000451865.5
ENST00000432135.1
ENST00000369809.5
ENST00000393638.5
ENST00000424626.5
ENST00000309585.9
deoxyribonuclease 1 like 1
chr20_-_38033424 0.45 ENST00000373447.8
ENST00000373448.6
TELO2 interacting protein 1
chr3_+_124094663 0.45 ENST00000460856.5
ENST00000240874.7
kalirin RhoGEF kinase
chr9_+_27109135 0.45 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr19_+_18386150 0.45 ENST00000252809.3
growth differentiation factor 15
chr1_-_167090370 0.45 ENST00000367868.4
glycoprotein A33
chr1_+_241532121 0.45 ENST00000366558.7
kynurenine 3-monooxygenase
chr3_-_53844617 0.44 ENST00000481668.5
ENST00000467802.1
choline dehydrogenase
chr2_-_218568291 0.43 ENST00000418019.5
ENST00000454775.5
ENST00000338465.5
ENST00000415516.5
ENST00000258399.8
ubiquitin specific peptidase 37
chr16_+_66566393 0.43 ENST00000332695.11
ENST00000336328.10
ENST00000457188.6
ENST00000528324.5
ENST00000529506.5
ENST00000531885.5
ENST00000533666.5
ENST00000533953.5
ENST00000379500.7
ENST00000328020.10
CKLF like MARVEL transmembrane domain containing 1
chr6_+_31723344 0.43 ENST00000480039.5
ENST00000375810.8
ENST00000375805.6
ENST00000375809.7
ENST00000649779.1
ENST00000375804.6
ENST00000375814.7
megakaryocyte and platelet inhibitory receptor G6b
chr5_+_80654644 0.42 ENST00000265081.7
mutS homolog 3
chr2_+_27890716 0.42 ENST00000344773.6
ENST00000379624.6
ENST00000342045.6
ENST00000379632.6
ENST00000361704.6
BRISC and BRCA1 A complex member 2
chr13_+_75760362 0.42 ENST00000534657.5
LIM domain 7
chr1_+_200027702 0.41 ENST00000367362.8
nuclear receptor subfamily 5 group A member 2
chr3_+_46877705 0.41 ENST00000449590.6
parathyroid hormone 1 receptor
chr11_-_116823293 0.40 ENST00000357780.5
apolipoprotein A4
chr7_+_101020073 0.39 ENST00000306151.9
mucin 17, cell surface associated
chr9_+_136945234 0.39 ENST00000371634.7
complement C8 gamma chain
chr12_-_118372883 0.39 ENST00000542532.5
ENST00000392533.8
TAO kinase 3
chr1_+_200027605 0.39 ENST00000236914.7
nuclear receptor subfamily 5 group A member 2
chr9_-_101442403 0.37 ENST00000648758.1
aldolase, fructose-bisphosphate B
chr3_+_124094696 0.37 ENST00000360013.7
ENST00000684186.1
ENST00000684276.1
kalirin RhoGEF kinase
chr5_+_154858482 0.37 ENST00000519211.5
ENST00000522458.5
ENST00000519903.5
ENST00000521450.5
ENST00000403027.6
CCR4-NOT transcription complex subunit 8
chr1_-_177969907 0.37 ENST00000308284.10
SEC16 homolog B, endoplasmic reticulum export factor
chr19_-_40750302 0.36 ENST00000598485.6
ENST00000378313.7
ENST00000470681.5
chromosome 19 open reading frame 54
chr5_+_154858218 0.36 ENST00000523698.5
ENST00000517876.5
ENST00000520472.5
CCR4-NOT transcription complex subunit 8
chr6_+_31982057 0.36 ENST00000428956.7
ENST00000498271.1
complement C4A (Rodgers blood group)
chr19_-_35812838 0.35 ENST00000653904.2
proline dehydrogenase 2
chr5_+_154858594 0.34 ENST00000519430.5
ENST00000520671.5
ENST00000521583.5
ENST00000285896.11
ENST00000518028.5
ENST00000519404.5
ENST00000519394.5
ENST00000518775.5
CCR4-NOT transcription complex subunit 8
chr4_+_94455245 0.34 ENST00000508216.5
ENST00000514743.5
PDZ and LIM domain 5
chr17_+_50548041 0.33 ENST00000634597.1
spermatogenesis associated 20
chr3_+_63911929 0.33 ENST00000487717.5
ataxin 7
chr1_+_241532370 0.33 ENST00000366559.9
ENST00000366557.8
kynurenine 3-monooxygenase
chr12_-_14696571 0.32 ENST00000261170.5
guanylate cyclase 2C
chr2_+_44275473 0.32 ENST00000260649.11
solute carrier family 3 member 1
chr2_+_48568981 0.32 ENST00000394754.5
STON1-GTF2A1L readthrough
chr11_-_10294194 0.31 ENST00000676387.1
ENST00000256190.13
ENST00000675281.1
SET binding factor 2
chr2_-_180007254 0.31 ENST00000410053.8
CWC22 spliceosome associated protein homolog
chr4_+_112231748 0.30 ENST00000274000.10
ENST00000309703.10
adaptor related protein complex 1 associated regulatory protein
chr11_+_1834804 0.30 ENST00000341958.3
synaptotagmin 8
chr13_+_75760659 0.29 ENST00000526202.5
ENST00000465261.6
LIM domain 7
chr19_-_38812936 0.29 ENST00000307751.9
ENST00000594209.1
galectin 4
chr1_-_23368301 0.29 ENST00000374608.3
zinc finger protein 436
chr1_-_27366917 0.28 ENST00000357582.3
mitogen-activated protein kinase kinase kinase 6
chrX_-_77786198 0.28 ENST00000624032.3
ENST00000624668.3
ENST00000373344.11
ENST00000395603.7
ENST00000624166.3
ENST00000623321.3
ENST00000622960.1
ATRX chromatin remodeler
chr13_+_75760431 0.28 ENST00000321797.12
LIM domain 7
chrX_-_53281524 0.28 ENST00000498281.2
IQ motif and Sec7 domain ArfGEF 2
chr1_-_155301423 0.27 ENST00000342741.6
pyruvate kinase L/R
chr14_+_23185316 0.26 ENST00000399910.5
ENST00000492621.5
ring finger protein 212B
chr4_+_108620584 0.26 ENST00000394665.5
ribosomal protein L34
chr11_+_119185469 0.26 ENST00000525131.5
ENST00000355547.10
ENST00000531114.5
ENST00000322712.4
PDZ domain containing 3
chr4_+_108620567 0.26 ENST00000502534.5
ENST00000394667.8
ribosomal protein L34
chr14_+_39267055 0.26 ENST00000396158.6
ENST00000280083.7
ENST00000341502.9
MIA SH3 domain ER export factor 2
chr9_-_68540879 0.25 ENST00000377311.4
transmembrane protein 252
chr6_+_32014795 0.25 ENST00000435363.7
ENST00000425700.3
complement C4B (Chido blood group)
chr6_-_29375291 0.25 ENST00000396806.3
olfactory receptor family 12 subfamily D member 3
chr16_-_16223467 0.25 ENST00000575728.1
ENST00000574094.6
ENST00000205557.12
ATP binding cassette subfamily C member 6
chr3_+_63912588 0.24 ENST00000522345.2
ataxin 7
chr5_+_154858537 0.24 ENST00000517568.5
ENST00000524105.5
CCR4-NOT transcription complex subunit 8
chr22_-_30667795 0.24 ENST00000404885.5
ENST00000403268.1
ENST00000407308.1
ENST00000334679.4
ENST00000342474.4
dual specificity phosphatase 18
chrX_+_154429092 0.23 ENST00000619046.5
ATPase H+ transporting accessory protein 1
chr11_+_1834415 0.23 ENST00000381968.7
ENST00000381978.7
synaptotagmin 8
chr20_-_45857196 0.23 ENST00000457981.5
ENST00000426915.1
ENST00000217455.9
acyl-CoA thioesterase 8
chr19_-_35135180 0.23 ENST00000392225.7
leucine rich repeat LGI family member 4
chr1_-_161223408 0.23 ENST00000491350.1
apolipoprotein A2
chr2_-_42792558 0.23 ENST00000431905.1
ENST00000294973.11
3-hydroxyanthranilate 3,4-dioxygenase
chr5_+_80319997 0.22 ENST00000296739.6
spermatogenic leucine zipper 1
chr17_+_1742836 0.22 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
serpin family F member 2
chr2_-_27890348 0.21 ENST00000302188.8
ribokinase
chr20_-_3663399 0.21 ENST00000290417.7
ENST00000319242.8
GDNF family receptor alpha 4
chr2_-_208129824 0.21 ENST00000282141.4
crystallin gamma C
chr1_+_180632001 0.21 ENST00000367590.9
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr19_-_35134861 0.21 ENST00000591633.2
leucine rich repeat LGI family member 4
chr10_-_102056116 0.21 ENST00000370033.9
ENST00000311122.5
armadillo like helical domain containing 3
chr4_+_108620616 0.21 ENST00000506397.5
ENST00000394668.2
ribosomal protein L34
chr9_-_29739 0.20 ENST00000442898.5
WASH complex subunit 1
chrX_+_154411519 0.20 ENST00000612460.5
ENST00000601016.6
ENST00000613002.4
ENST00000475699.6
ENST00000612012.5
ENST00000369776.8
ENST00000439735.2
ENST00000616020.5
ENST00000652358.1
ENST00000652390.1
tafazzin
chr2_+_61162185 0.20 ENST00000432605.3
ENST00000488469.4
chromosome 2 open reading frame 74
chr19_+_7595830 0.20 ENST00000160298.9
ENST00000446248.4
calmodulin regulated spectrin associated protein family member 3
chr19_+_15641280 0.20 ENST00000585846.1
cytochrome P450 family 4 subfamily F member 3
chr19_+_39391323 0.19 ENST00000615911.4
ENST00000315588.11
ENST00000594368.5
ENST00000596297.1
mediator complex subunit 29
chr15_-_63156774 0.19 ENST00000462430.5
ribosomal protein S27 like
chr7_-_78771265 0.18 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_-_194351290 0.18 ENST00000429275.1
ENST00000323830.4
carboxypeptidase N subunit 2
chr14_+_100019375 0.17 ENST00000544450.6
Enah/Vasp-like
chr5_+_177384430 0.17 ENST00000512593.5
ENST00000324417.6
solute carrier family 34 member 1
chr15_+_51341648 0.17 ENST00000335449.11
ENST00000560215.5
gliomedin
chr6_+_31959130 0.17 ENST00000375394.7
ENST00000628157.1
Ski2 like RNA helicase
chrX_-_43882411 0.16 ENST00000378069.5
monoamine oxidase B
chr18_+_56651385 0.16 ENST00000615645.4
WD repeat domain 7
chr11_+_63369779 0.16 ENST00000279178.4
solute carrier family 22 member 9
chr19_-_35135011 0.16 ENST00000310123.8
leucine rich repeat LGI family member 4
chr18_+_56651335 0.16 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WD repeat domain 7
chr17_+_50346099 0.16 ENST00000017003.7
ENST00000509778.1
ENST00000507602.5
xylosyltransferase 2
chr7_-_87475839 0.15 ENST00000359206.8
ATP binding cassette subfamily B member 4
chr19_+_15615211 0.15 ENST00000617645.4
ENST00000612078.5
cytochrome P450 family 4 subfamily F member 8
chr15_+_50424377 0.14 ENST00000560297.5
ENST00000396444.7
ENST00000425032.7
ENST00000307179.9
ENST00000625664.2
ubiquitin specific peptidase 8
chr22_+_24607602 0.14 ENST00000447416.5
gamma-glutamyltransferase 1
chr18_+_59225492 0.14 ENST00000456142.3
ENST00000530323.1
gastrin releasing peptide
chr19_-_35852495 0.14 ENST00000378910.10
NPHS1 adhesion molecule, nephrin
chr1_-_40665435 0.14 ENST00000372683.1
regulating synaptic membrane exocytosis 3
chr11_+_63888515 0.14 ENST00000509502.6
ENST00000512060.1
microtubule affinity regulating kinase 2
chr12_-_53200443 0.14 ENST00000550743.6
integrin subunit beta 7
chr6_-_32178080 0.13 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr11_-_707063 0.13 ENST00000683307.1
DEAF1 transcription factor
chr1_+_48222685 0.13 ENST00000533824.5
ENST00000236495.9
ENST00000438567.7
solute carrier family 5 member 9
chr12_+_120978537 0.12 ENST00000257555.11
ENST00000400024.6
HNF1 homeobox A
chr15_-_73633310 0.11 ENST00000345330.9
neuroplastin
chr5_+_90899183 0.11 ENST00000640815.1
adhesion G protein-coupled receptor V1
chr6_+_30626842 0.11 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
alpha tubulin acetyltransferase 1
chr2_-_158456702 0.10 ENST00000409889.1
ENST00000283233.10
coiled-coil domain containing 148
chr7_-_143647646 0.10 ENST00000636941.1
TRPM8 channel associated factor 2C
chr6_-_149484965 0.10 ENST00000409806.8
zinc finger CCCH-type containing 12D
chr5_+_1801387 0.10 ENST00000274137.10
ENST00000469176.1
NADH:ubiquinone oxidoreductase subunit S6
chr6_+_43298326 0.10 ENST00000372574.7
solute carrier family 22 member 7
chr12_+_108880085 0.10 ENST00000228476.8
ENST00000547768.5
D-amino acid oxidase
chr16_-_88686453 0.09 ENST00000332281.6
snail family transcriptional repressor 3
chr14_+_77181780 0.09 ENST00000298351.5
ENST00000554346.5
transmembrane protein 63C
chr19_-_7632971 0.09 ENST00000598935.5
Purkinje cell protein 2
chr5_-_16508812 0.09 ENST00000683414.1
reticulophagy regulator 1
chr19_-_48835823 0.08 ENST00000595764.1
hydroxysteroid 17-beta dehydrogenase 14
chr2_+_74421721 0.08 ENST00000409791.5
ENST00000348227.4
WD repeat domain 54
chr18_+_3262098 0.08 ENST00000237500.10
myosin light chain 12B
chr3_-_9878765 0.07 ENST00000430427.6
ENST00000383817.5
ENST00000679265.1
cell death inducing DFFA like effector c

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.6 2.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.4 1.5 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.4 1.2 GO:0060003 copper ion export(GO:0060003)
0.4 1.8 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.3 10.2 GO:0072189 ureter development(GO:0072189)
0.3 0.8 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 1.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.7 GO:0036482 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.2 1.0 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.2 0.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.6 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.2 0.6 GO:1904719 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.2 1.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 1.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.2 0.6 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.2 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 0.5 GO:1903028 positive regulation of opsonization(GO:1903028)
0.2 2.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.1 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.1 1.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 1.4 GO:0015747 urate transport(GO:0015747)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.9 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.7 GO:0031337 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.1 0.4 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 1.6 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.1 0.4 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.1 0.9 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.3 GO:1904908 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.1 0.6 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.7 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.5 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) cellular lipid biosynthetic process(GO:0097384)
0.1 0.5 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.8 GO:0060125 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.1 0.5 GO:0046440 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.2 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 0.2 GO:2001025 response to cyclosporin A(GO:1905237) positive regulation of response to drug(GO:2001025)
0.1 0.3 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.2 GO:2000909 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.1 0.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.2 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.6 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.4 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 3.0 GO:1901998 toxin transport(GO:1901998)
0.0 0.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.5 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 1.0 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 2.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 1.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 1.5 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.4 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 1.4 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.0 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.5 GO:0006308 DNA catabolic process(GO:0006308)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.1 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.6 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.4 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 1.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.3 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading(GO:1900025)
0.0 1.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 1.1 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561) fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) alpha-linolenic acid metabolic process(GO:0036109)
0.0 1.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.2 1.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 0.4 GO:0032302 MutSbeta complex(GO:0032302)
0.1 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.2 GO:0055087 Ski complex(GO:0055087)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.4 GO:0070552 BRISC complex(GO:0070552)
0.0 2.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.4 1.2 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.4 1.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.4 2.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 1.5 GO:0031711 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.3 2.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 1.5 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.0 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.2 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 2.1 GO:0042731 PH domain binding(GO:0042731)
0.1 0.5 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 0.4 GO:0061609 fructose-1-phosphate aldolase activity(GO:0061609)
0.1 1.5 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.5 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.4 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 0.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 1.0 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.5 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.4 GO:0000406 double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.9 GO:0008430 selenium binding(GO:0008430)
0.1 0.2 GO:0052816 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.1 0.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.7 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.4 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 0.7 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.2 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.5 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.7 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.3 GO:0016936 galactoside binding(GO:0016936)
0.1 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.2 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.6 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.3 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 11.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.0 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 3.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis