ISMARA results: HOXA2

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HOXA2_HOXB1

Z-value: 0.31

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol	Gene ID	Gene Info
HOXA2 Ensembl NCBI GeneCards UniProt	ENSG00000105996.7	HOXA2
HOXB1 Ensembl NCBI GeneCards UniProt	ENSG00000120094.9	HOXB1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXA2	hg38_v1_chr7_-_27102669_27102691	0.48	1.6e-02	Click!
HOXB1	hg38_v1_chr17_-_48530910_48531026	0.00	1.0e+00	Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

View svg image
View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr2_+_12716893 Show fit	0.83	ENST00000381465.2 ENST00000155926.9	TRIB2 Ensembl NCBI GeneCards UniProt Show fit	tribbles pseudokinase 2
chr4_-_89836213 Show fit	0.62	ENST00000618500.4 ENST00000508895.5	SNCA Ensembl NCBI GeneCards UniProt Show fit	synuclein alpha
chr4_-_89835617 Show fit	0.61	ENST00000611107.1 ENST00000345009.8 ENST00000505199.5 ENST00000502987.5	SNCA Ensembl NCBI GeneCards UniProt Show fit	synuclein alpha
chr17_+_7855055 Show fit	0.58	ENST00000574668.1 ENST00000301599.7	TMEM88 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 88
chr1_-_91886144 Show fit	0.46	ENST00000212355.9	TGFBR3 Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor beta receptor 3
chr18_+_59220149 Show fit	0.43	ENST00000256857.7 ENST00000529320.2 ENST00000420468.6	GRP Ensembl NCBI GeneCards UniProt Show fit	gastrin releasing peptide
chr8_+_76683779 Show fit	0.40	ENST00000523885.2	ZFHX4 Ensembl NCBI GeneCards UniProt Show fit	zinc finger homeobox 4
chr20_+_43945677 Show fit	0.35	ENST00000358131.5	TOX2 Ensembl NCBI GeneCards UniProt Show fit	TOX high mobility group box family member 2
chr12_+_101594849 Show fit	0.32	ENST00000547405.5 ENST00000452455.6 ENST00000392934.7 ENST00000547509.5 ENST00000361685.6 ENST00000549145.5 ENST00000361466.7 ENST00000553190.5 ENST00000545503.6 ENST00000536007.5 ENST00000541119.5 ENST00000551300.5 ENST00000550270.1	MYBPC1 Ensembl NCBI GeneCards UniProt Show fit	myosin binding protein C1
chr15_-_93073111 Show fit	0.30	ENST00000557420.1 ENST00000542321.6	RGMA Ensembl NCBI GeneCards UniProt Show fit	repulsive guidance molecule BMP co-receptor a
chrX_-_10677720 Show fit	0.29	ENST00000453318.6	MID1 Ensembl NCBI GeneCards UniProt Show fit	midline 1
chr7_+_80135694 Show fit	0.28	ENST00000457358.7	GNAI1 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha i1
chr20_+_36154630 Show fit	0.27	ENST00000338074.7 ENST00000636016.2 ENST00000373945.5	EPB41L1 Ensembl NCBI GeneCards UniProt Show fit	erythrocyte membrane protein band 4.1 like 1
chr20_+_36214373 Show fit	0.25	ENST00000432603.1	EPB41L1 Ensembl NCBI GeneCards UniProt Show fit	erythrocyte membrane protein band 4.1 like 1
chr7_-_120857124 Show fit	0.25	ENST00000441017.5 ENST00000424710.5 ENST00000433758.5	TSPAN12 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 12
chr7_+_86643902 Show fit	0.22	ENST00000361669.7	GRM3 Ensembl NCBI GeneCards UniProt Show fit	glutamate metabotropic receptor 3
chr5_-_88785493 Show fit	0.22	ENST00000503554.4	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr17_-_44199206 Show fit	0.20	ENST00000589805.1	ATXN7L3 Ensembl NCBI GeneCards UniProt Show fit	ataxin 7 like 3
chr2_-_44361555 Show fit	0.20	ENST00000409957.5	PREPL Ensembl NCBI GeneCards UniProt Show fit	prolyl endopeptidase like
chr15_+_47717344 Show fit	0.19	ENST00000558816.5 ENST00000536845.7	SEMA6D Ensembl NCBI GeneCards UniProt Show fit	semaphorin 6D
chr7_-_86965872 Show fit	0.18	ENST00000398276.6 ENST00000416314.5 ENST00000425689.1	ELAPOR2 Ensembl NCBI GeneCards UniProt Show fit	endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr12_-_14885845 Show fit	0.17	ENST00000539261.6 ENST00000228938.5	MGP Ensembl NCBI GeneCards UniProt Show fit	matrix Gla protein
chr2_-_153478753 Show fit	0.17	ENST00000325926.4	RPRM Ensembl NCBI GeneCards UniProt Show fit	reprimo, TP53 dependent G2 arrest mediator homolog
chr4_-_137532452 Show fit	0.17	ENST00000412923.6 ENST00000511115.5 ENST00000344876.9 ENST00000507846.5 ENST00000510305.5 ENST00000611581.1	PCDH18 Ensembl NCBI GeneCards UniProt Show fit	protocadherin 18
chr1_+_51617079 Show fit	0.16	ENST00000447887.5 ENST00000428468.6 ENST00000453295.5	OSBPL9 Ensembl NCBI GeneCards UniProt Show fit	oxysterol binding protein like 9
chr13_-_77919390 Show fit	0.16	ENST00000475537.2 ENST00000646605.1	EDNRB Ensembl NCBI GeneCards UniProt Show fit	endothelin receptor type B
chr18_-_55403682 Show fit	0.16	ENST00000564228.5 ENST00000630828.2	TCF4 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 4
chr16_-_49856105 Show fit	0.16	ENST00000563137.7	ZNF423 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 423
chr16_+_15502266 Show fit	0.15	ENST00000452191.6	BMERB1 Ensembl NCBI GeneCards UniProt Show fit	bMERB domain containing 1
chr1_+_64470120 Show fit	0.14	ENST00000651257.2	CACHD1 Ensembl NCBI GeneCards UniProt Show fit	cache domain containing 1
chr5_-_126595237 Show fit	0.13	ENST00000637206.1 ENST00000553117.5	ALDH7A1 Ensembl NCBI GeneCards UniProt Show fit	aldehyde dehydrogenase 7 family member A1
chr5_-_179617581 Show fit	0.12	ENST00000523449.5	HNRNPH1 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein H1
chr7_-_144410227 Show fit	0.12	ENST00000467773.1 ENST00000483238.5	NOBOX Ensembl NCBI GeneCards UniProt Show fit	NOBOX oogenesis homeobox
chr10_+_35175586 Show fit	0.12	ENST00000494479.5 ENST00000463314.5 ENST00000342105.7 ENST00000495301.1	CREM Ensembl NCBI GeneCards UniProt Show fit	cAMP responsive element modulator
chr10_+_122560639 Show fit	0.11	ENST00000344338.7 ENST00000330163.8 ENST00000652446.2 ENST00000666315.1 ENST00000368955.7 ENST00000368909.7 ENST00000368956.6 ENST00000619379.1	DMBT1 Ensembl NCBI GeneCards UniProt Show fit	deleted in malignant brain tumors 1
chr10_+_122560679 Show fit	0.11	ENST00000657942.1	DMBT1 Ensembl NCBI GeneCards UniProt Show fit	deleted in malignant brain tumors 1
chr5_-_126595185 Show fit	0.11	ENST00000510111.6 ENST00000635851.1 ENST00000637964.1 ENST00000413020.6 ENST00000637782.1 ENST00000409134.8 ENST00000637272.1 ENST00000636879.1 ENST00000636743.1 ENST00000636886.1 ENST00000509270.2	ALDH7A1 Ensembl NCBI GeneCards UniProt Show fit	aldehyde dehydrogenase 7 family member A1
chr10_+_122560751 Show fit	0.11	ENST00000338354.10 ENST00000664692.1 ENST00000653442.1 ENST00000664974.1	DMBT1 Ensembl NCBI GeneCards UniProt Show fit	deleted in malignant brain tumors 1
chr6_-_112254485 Show fit	0.10	ENST00000521398.5 ENST00000424408.6 ENST00000243219.7	LAMA4 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit alpha 4
chr3_+_189789672 Show fit	0.10	ENST00000434928.5	TP63 Ensembl NCBI GeneCards UniProt Show fit	tumor protein p63
chr2_+_26401909 Show fit	0.10	ENST00000288710.7	DRC1 Ensembl NCBI GeneCards UniProt Show fit	dynein regulatory complex subunit 1
chr10_-_63269057 Show fit	0.09	ENST00000542921.5	JMJD1C Ensembl NCBI GeneCards UniProt Show fit	jumonji domain containing 1C
chr10_-_77637633 Show fit	0.08	ENST00000638223.1 ENST00000639544.1 ENST00000640807.1 ENST00000434208.6 ENST00000626620.3 ENST00000638575.1 ENST00000638759.1	KCNMA1 Ensembl NCBI GeneCards UniProt Show fit	potassium calcium-activated channel subfamily M alpha 1
chr3_-_51779187 Show fit	0.07	ENST00000398780.5 ENST00000668964.1 ENST00000667863.2 ENST00000647442.1	IQCF6 Ensembl NCBI GeneCards UniProt Show fit	IQ motif containing F6
chr17_+_60677822 Show fit	0.07	ENST00000407086.8 ENST00000589222.5 ENST00000626960.2 ENST00000390652.9	BCAS3 Ensembl NCBI GeneCards UniProt Show fit	BCAS3 microtubule associated cell migration factor
chr1_-_107965009 Show fit	0.07	ENST00000527011.5 ENST00000370056.9	VAV3 Ensembl NCBI GeneCards UniProt Show fit	vav guanine nucleotide exchange factor 3
chr6_+_32038382 Show fit	0.07	ENST00000478281.5 ENST00000471671.4 ENST00000435122.3 ENST00000644719.2	CYP21A2 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 21 subfamily A member 2
chr12_+_57089094 Show fit	0.07	ENST00000342556.6 ENST00000300131.8	NAB2 Ensembl NCBI GeneCards UniProt Show fit	NGFI-A binding protein 2
chr9_+_26947039 Show fit	0.07	ENST00000519968.5 ENST00000433700.5	IFT74 Ensembl NCBI GeneCards UniProt Show fit	intraflagellar transport 74
chr7_-_27102669 Show fit	0.07	ENST00000222718.7	HOXA2 Ensembl NCBI GeneCards UniProt Show fit	homeobox A2
chr6_-_112254647 Show fit	0.07	ENST00000455073.1 ENST00000522006.5 ENST00000519932.5	LAMA4 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit alpha 4
chr6_+_122996227 Show fit	0.07	ENST00000275162.10	CLVS2 Ensembl NCBI GeneCards UniProt Show fit	clavesin 2
chr6_+_151239951 Show fit	0.07	ENST00000402676.7	AKAP12 Ensembl NCBI GeneCards UniProt Show fit	A-kinase anchoring protein 12
chr19_-_51009586 Show fit	0.07	ENST00000594211.2	KLK9 Ensembl NCBI GeneCards UniProt Show fit	kallikrein related peptidase 9
chr8_-_66962563 Show fit	0.06	ENST00000563496.2	TCF24 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 24
chr20_-_32584795 Show fit	0.06	ENST00000201961.6 ENST00000621426.6	NOL4L Ensembl NCBI GeneCards UniProt Show fit	nucleolar protein 4 like
chr6_-_32128191 Show fit	0.06	ENST00000453203.2 ENST00000375203.8 ENST00000375201.8	ATF6B Ensembl NCBI GeneCards UniProt Show fit	activating transcription factor 6 beta
chr5_+_148202771 Show fit	0.06	ENST00000514389.5 ENST00000621437.4	SPINK6 Ensembl NCBI GeneCards UniProt Show fit	serine peptidase inhibitor Kazal type 6
chr10_-_121596117 Show fit	0.06	ENST00000351936.11	FGFR2 Ensembl NCBI GeneCards UniProt Show fit	fibroblast growth factor receptor 2
chr11_-_2140967 Show fit	0.06	ENST00000381389.5	IGF2 Ensembl NCBI GeneCards UniProt Show fit	insulin like growth factor 2
chr13_-_35476682 Show fit	0.05	ENST00000379919.6	MAB21L1 Ensembl NCBI GeneCards UniProt Show fit	mab-21 like 1
chr2_+_134254065 Show fit	0.05	ENST00000281923.4	MGAT5 Ensembl NCBI GeneCards UniProt Show fit	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
chr3_+_148827800 Show fit	0.05	ENST00000282957.9 ENST00000468341.1	CPB1 Ensembl NCBI GeneCards UniProt Show fit	carboxypeptidase B1
chr10_+_101131284 Show fit	0.05	ENST00000370196.11 ENST00000467928.2	TLX1 Ensembl NCBI GeneCards UniProt Show fit	T cell leukemia homeobox 1
chr6_-_112254555 Show fit	0.05	ENST00000230538.12 ENST00000389463.9 ENST00000368638.5 ENST00000431543.6 ENST00000453937.2	LAMA4 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit alpha 4
chr1_+_243256034 Show fit	0.05	ENST00000366541.8	SDCCAG8 Ensembl NCBI GeneCards UniProt Show fit	SHH signaling and ciliogenesis regulator SDCCAG8
chr3_+_150546765 Show fit	0.05	ENST00000406576.7 ENST00000460851.6 ENST00000482093.5 ENST00000273435.9	EIF2A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2A
chr11_+_26188836 Show fit	0.05	ENST00000672621.1	ANO3 Ensembl NCBI GeneCards UniProt Show fit	anoctamin 3
chr8_-_78805306 Show fit	0.04	ENST00000639719.1 ENST00000263851.9	IL7 Ensembl NCBI GeneCards UniProt Show fit	interleukin 7
chr10_+_100745570 Show fit	0.04	ENST00000427256.6 ENST00000355243.8	PAX2 Ensembl NCBI GeneCards UniProt Show fit	paired box 2
chr8_-_66613229 Show fit	0.04	ENST00000517885.5	MYBL1 Ensembl NCBI GeneCards UniProt Show fit	MYB proto-oncogene like 1
chr3_+_150546671 Show fit	0.04	ENST00000487799.5	EIF2A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2A
chr12_-_27971970 Show fit	0.04	ENST00000395872.5 ENST00000201015.8	PTHLH Ensembl NCBI GeneCards UniProt Show fit	parathyroid hormone like hormone
chr13_+_35476740 Show fit	0.04	ENST00000537702.5	NBEA Ensembl NCBI GeneCards UniProt Show fit	neurobeachin
chr15_-_74208969 Show fit	0.04	ENST00000423167.6 ENST00000432245.6	STRA6 Ensembl NCBI GeneCards UniProt Show fit	signaling receptor and transporter of retinol STRA6
chrX_+_100644183 Show fit	0.04	ENST00000640889.1 ENST00000373004.5	SRPX2 Ensembl NCBI GeneCards UniProt Show fit	sushi repeat containing protein X-linked 2
chr17_-_39197652 Show fit	0.04	ENST00000394303.8	CACNB1 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit beta 1
chr12_+_7130341 Show fit	0.04	ENST00000266546.11	CLSTN3 Ensembl NCBI GeneCards UniProt Show fit	calsyntenin 3
chr16_+_85611401 Show fit	0.04	ENST00000405402.6	GSE1 Ensembl NCBI GeneCards UniProt Show fit	Gse1 coiled-coil protein
chr10_+_49988318 Show fit	0.04	ENST00000374056.10 ENST00000679810.1	AGAP6 Ensembl NCBI GeneCards UniProt Show fit	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
chr19_+_37506931 Show fit	0.04	ENST00000627814.3 ENST00000587143.5	ZNF793 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 793
chr10_+_100745711 Show fit	0.03	ENST00000370296.6 ENST00000428433.5	PAX2 Ensembl NCBI GeneCards UniProt Show fit	paired box 2
chr14_+_22516273 Show fit	0.03	ENST00000390510.1	TRAJ27 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor alpha joining 27
chrX_+_126819720 Show fit	0.03	ENST00000371125.4	PRR32 Ensembl NCBI GeneCards UniProt Show fit	proline rich 32
chr19_-_49441508 Show fit	0.03	ENST00000221485.8	SLC17A7 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 17 member 7
chr8_-_78805515 Show fit	0.03	ENST00000379113.6 ENST00000541183.2	IL7 Ensembl NCBI GeneCards UniProt Show fit	interleukin 7
chr5_+_148203024 Show fit	0.03	ENST00000325630.3	SPINK6 Ensembl NCBI GeneCards UniProt Show fit	serine peptidase inhibitor Kazal type 6
chr17_+_41819201 Show fit	0.03	ENST00000455106.1	FKBP10 Ensembl NCBI GeneCards UniProt Show fit	FKBP prolyl isomerase 10
chr7_-_101237827 Show fit	0.03	ENST00000611078.4	CLDN15 Ensembl NCBI GeneCards UniProt Show fit	claudin 15
chr4_+_76435216 Show fit	0.03	ENST00000296043.7	SHROOM3 Ensembl NCBI GeneCards UniProt Show fit	shroom family member 3
chr17_+_81528370 Show fit	0.03	ENST00000417245.7 ENST00000334850.7	FSCN2 Ensembl NCBI GeneCards UniProt Show fit	fascin actin-bundling protein 2, retinal
chr11_-_128842467 Show fit	0.03	ENST00000392664.2	KCNJ1 Ensembl NCBI GeneCards UniProt Show fit	potassium inwardly rectifying channel subfamily J member 1
chr12_-_57742120 Show fit	0.03	ENST00000257897.7	AGAP2 Ensembl NCBI GeneCards UniProt Show fit	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chrX_-_66033664 Show fit	0.03	ENST00000427538.5	VSIG4 Ensembl NCBI GeneCards UniProt Show fit	V-set and immunoglobulin domain containing 4
chr7_-_144259722 Show fit	0.03	ENST00000493325.1	OR2A7 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor family 2 subfamily A member 7
chr8_+_142449430 Show fit	0.03	ENST00000643448.1 ENST00000517894.5	ADGRB1 Ensembl NCBI GeneCards UniProt Show fit	adhesion G protein-coupled receptor B1
chr15_+_81299416 Show fit	0.02	ENST00000558332.3	IL16 Ensembl NCBI GeneCards UniProt Show fit	interleukin 16
chr17_+_45161864 Show fit	0.02	ENST00000589230.6 ENST00000591576.5 ENST00000591070.6 ENST00000592695.1	HEXIM2 Ensembl NCBI GeneCards UniProt Show fit	HEXIM P-TEFb complex subunit 2
chr1_-_109041986 Show fit	0.02	ENST00000400794.7 ENST00000528747.1 ENST00000361054.7	WDR47 Ensembl NCBI GeneCards UniProt Show fit	WD repeat domain 47
chr7_-_13989891 Show fit	0.02	ENST00000405218.6	ETV1 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 1
chr9_+_110668854 Show fit	0.02	ENST00000189978.10 ENST00000374440.7	MUSK Ensembl NCBI GeneCards UniProt Show fit	muscle associated receptor tyrosine kinase
chr7_-_13989658 Show fit	0.02	ENST00000430479.6 ENST00000433547.1 ENST00000405192.6	ETV1 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 1
chrX_-_111412162 Show fit	0.02	ENST00000637570.1 ENST00000356220.8 ENST00000636035.2 ENST00000637453.1 ENST00000635795.1	DCX Ensembl NCBI GeneCards UniProt Show fit	doublecortin
chr9_+_110668779 Show fit	0.02	ENST00000416899.7 ENST00000374448.9	MUSK Ensembl NCBI GeneCards UniProt Show fit	muscle associated receptor tyrosine kinase
chr3_+_189789734 Show fit	0.02	ENST00000437221.5 ENST00000392463.6 ENST00000392461.7 ENST00000449992.5 ENST00000456148.1	TP63 Ensembl NCBI GeneCards UniProt Show fit	tumor protein p63
chr11_-_123059413 Show fit	0.02	ENST00000524552.5	HSPA8 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 8
chr11_+_57597563 Show fit	0.01	ENST00000619430.2 ENST00000457869.1 ENST00000340687.10 ENST00000278407.9 ENST00000378323.8 ENST00000378324.6 ENST00000403558.1	SERPING1 Ensembl NCBI GeneCards UniProt Show fit	serpin family G member 1
chr10_-_77637721 Show fit	0.01	ENST00000638848.1 ENST00000639406.1 ENST00000618048.2 ENST00000639120.1 ENST00000640834.1 ENST00000639601.1 ENST00000638514.1 ENST00000457953.6 ENST00000639090.1 ENST00000639489.1 ENST00000372440.6 ENST00000404771.8 ENST00000638203.1 ENST00000638306.1 ENST00000638351.1 ENST00000638606.1 ENST00000639591.1 ENST00000640182.1 ENST00000640605.1 ENST00000640141.1	KCNMA1 Ensembl NCBI GeneCards UniProt Show fit	potassium calcium-activated channel subfamily M alpha 1
chr21_+_18244828 Show fit	0.01	ENST00000299295.7	CHODL Ensembl NCBI GeneCards UniProt Show fit	chondrolectin
chr10_+_94089034 Show fit	0.01	ENST00000676102.1 ENST00000371385.8	PLCE1 Ensembl NCBI GeneCards UniProt Show fit	phospholipase C epsilon 1
chr7_-_151167692 Show fit	0.01	ENST00000297537.5	GBX1 Ensembl NCBI GeneCards UniProt Show fit	gastrulation brain homeobox 1
chr10_-_77637789 Show fit	0.01	ENST00000481070.1 ENST00000640969.1 ENST00000286628.14 ENST00000638991.1 ENST00000639913.1 ENST00000480683.2	KCNMA1 Ensembl NCBI GeneCards UniProt Show fit	potassium calcium-activated channel subfamily M alpha 1
chr13_-_77919459 Show fit	0.01	ENST00000643890.1	EDNRB Ensembl NCBI GeneCards UniProt Show fit	endothelin receptor type B
chr18_+_21363593 Show fit	0.01	ENST00000580732.6	GREB1L Ensembl NCBI GeneCards UniProt Show fit	GREB1 like retinoic acid receptor coactivator
chr11_+_68460712 Show fit	0.01	ENST00000528635.5 ENST00000533127.5 ENST00000529907.5 ENST00000529344.5 ENST00000534534.5 ENST00000524845.5 ENST00000393800.7 ENST00000265637.8 ENST00000524904.5 ENST00000393801.7 ENST00000265636.9 ENST00000529710.5	PPP6R3 Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 6 regulatory subunit 3
chr8_-_66613208 Show fit	0.01	ENST00000522677.8	MYBL1 Ensembl NCBI GeneCards UniProt Show fit	MYB proto-oncogene like 1
chr17_-_39197696 Show fit	0.01	ENST00000394310.7 ENST00000622445.4 ENST00000344140.5	CACNB1 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit beta 1
chr5_-_179618032 Show fit	0.01	ENST00000519033.5	HNRNPH1 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein H1
chr1_+_66924895 Show fit	0.01	ENST00000355977.10 ENST00000371018.7 ENST00000357692.6 ENST00000371016.5 ENST00000371014.5 ENST00000371012.6 ENST00000401041.6	MIER1 Ensembl NCBI GeneCards UniProt Show fit	MIER1 transcriptional regulator
chr10_+_94089067 Show fit	0.01	ENST00000371375.1 ENST00000675218.1	PLCE1 Ensembl NCBI GeneCards UniProt Show fit	phospholipase C epsilon 1
chr17_-_1684807 Show fit	0.01	ENST00000577001.1 ENST00000572621.5 ENST00000304992.11	PRPF8 Ensembl NCBI GeneCards UniProt Show fit	pre-mRNA processing factor 8
chr15_-_74209019 Show fit	0.01	ENST00000323940.9	STRA6 Ensembl NCBI GeneCards UniProt Show fit	signaling receptor and transporter of retinol STRA6
chr1_-_44788168 Show fit	0.01	ENST00000372207.4	BEST4 Ensembl NCBI GeneCards UniProt Show fit	bestrophin 4
chr1_-_66924791 Show fit	0.01	ENST00000371023.7 ENST00000371022.3 ENST00000371026.8	DNAI4 Ensembl NCBI GeneCards UniProt Show fit	dynein axonemal intermediate chain 4
chr11_-_123058991 Show fit	0.01	ENST00000526686.1	HSPA8 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family A (Hsp70) member 8
chr7_-_126533850 Show fit	0.01	ENST00000444921.3	GRM8 Ensembl NCBI GeneCards UniProt Show fit	glutamate metabotropic receptor 8
chr12_+_56021005 Show fit	0.00	ENST00000547167.6	IKZF4 Ensembl NCBI GeneCards UniProt Show fit	IKAROS family zinc finger 4
chr2_-_152098810 Show fit	0.00	ENST00000636442.1 ENST00000638005.1	CACNB4 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit beta 4
chr12_-_114406133 Show fit	0.00	ENST00000405440.7	TBX5 Ensembl NCBI GeneCards UniProt Show fit	T-box transcription factor 5
chrX_+_70062457 Show fit	0.00	ENST00000338352.3	OTUD6A Ensembl NCBI GeneCards UniProt Show fit	OTU deubiquitinase 6A
chr20_+_21303303 Show fit	0.00	ENST00000377191.5	XRN2 Ensembl NCBI GeneCards UniProt Show fit	5'-3' exoribonuclease 2
chr8_-_142917843 Show fit	0.00	ENST00000323110.2	CYP11B2 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 11 subfamily B member 2
chr10_-_45847473 Show fit	0.00	ENST00000448048.7	AGAP4 Ensembl NCBI GeneCards UniProt Show fit	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr8_-_142879820 Show fit	0.00	ENST00000377675.3 ENST00000517471.5 ENST00000292427.10	CYP11B1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 11 subfamily B member 1
chr12_-_27972725 Show fit	0.00	ENST00000545234.6	PTHLH Ensembl NCBI GeneCards UniProt Show fit	parathyroid hormone like hormone
chr1_-_217076889 Show fit	0.00	ENST00000493748.5 ENST00000463665.5	ESRRG Ensembl NCBI GeneCards UniProt Show fit	estrogen related receptor gamma
chr10_-_99235783 Show fit	0.00	ENST00000370546.5 ENST00000614306.1	HPSE2 Ensembl NCBI GeneCards UniProt Show fit	heparanase 2 (inactive)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.2	1.2	GO:0051622	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1	0.5	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.1	0.4	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1	0.2	GO:0031455	glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0	0.2	GO:0035645	enteric smooth muscle cell differentiation(GO:0035645)
0.0	0.3	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0003138	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0	0.1	GO:0021658	rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.0	0.3	GO:1904321	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0	0.1	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.0	0.1	GO:0021634	optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.0	0.3	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.3	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	0.3	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.0	0.2	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0	0.0	GO:0042137	sequestering of neurotransmitter(GO:0042137)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	1.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.3	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.3	GO:0032982	myosin filament(GO:0032982)
0.0	0.2	GO:0000124	SAGA complex(GO:0000124)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.2	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.1	0.3	GO:0035375	zymogen binding(GO:0035375)
0.1	0.2	GO:0001641	group II metabotropic glutamate receptor activity(GO:0001641)
0.0	0.8	GO:0055106	ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.5	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0010698	acetyltransferase activator activity(GO:0010698)
0.0	0.2	GO:0004962	endothelin receptor activity(GO:0004962)
0.0	0.3	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.3	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.3	GO:0031432	titin binding(GO:0031432)
0.0	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.3	PID S1P S1P4 PATHWAY	S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.3	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway

Results for HOXA2_HOXB1

Z-value: 0.31

Motif logo

Transcription factors associated with HOXA2_HOXB1

Activity-expression correlation:

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: