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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HOXB13

Z-value: 0.60

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.8 HOXB13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg38_v1_chr17_-_48728705_487287560.164.5e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_84164962 2.92 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr9_-_14180779 2.26 ENST00000380924.1
ENST00000543693.5
NFIB
nuclear factor I B
chr1_+_84164370 2.25 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr16_+_30378312 2.02 ENST00000528032.5
ENST00000622647.3
ZNF48
zinc finger protein 48
chr7_-_11832190 1.94 ENST00000423059.9
ENST00000617773.1
THSD7A
thrombospondin type 1 domain containing 7A
chr8_+_96584920 1.26 ENST00000521590.5
SDC2
syndecan 2
chr15_+_66702219 1.17 ENST00000288840.10
SMAD6
SMAD family member 6
chr3_-_15798184 1.05 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr3_-_15797930 1.01 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr1_+_65992389 0.86 ENST00000423207.6
PDE4B
phosphodiesterase 4B
chr18_-_55322215 0.81 ENST00000457482.7
TCF4
transcription factor 4
chr2_+_172860038 0.79 ENST00000538974.5
ENST00000540783.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr18_-_55321986 0.69 ENST00000570287.6
TCF4
transcription factor 4
chr21_-_34526850 0.66 ENST00000481448.5
ENST00000381132.6
RCAN1
regulator of calcineurin 1
chr20_+_58907981 0.55 ENST00000656419.1
GNAS
GNAS complex locus
chr1_+_84164684 0.54 ENST00000370680.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr9_+_73151833 0.54 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
ANXA1
annexin A1
chr11_+_118531183 0.54 ENST00000528373.5
ENST00000313236.10
ENST00000354284.8
ENST00000533137.5
ENST00000532762.5
ENST00000526973.5
ENST00000354064.11
ENST00000533102.5
ENST00000527267.1
ENST00000524725.5
ENST00000533689.1
TMEM25
transmembrane protein 25
chr11_+_118530990 0.51 ENST00000411589.6
ENST00000359862.8
ENST00000442938.6
TMEM25
transmembrane protein 25
chr16_-_24931090 0.49 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr16_-_24930952 0.47 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr6_+_6588708 0.46 ENST00000230568.5
LY86
lymphocyte antigen 86
chr16_+_2155698 0.44 ENST00000565383.5
ENST00000326181.11
ENST00000567653.5
TRAF7
TNF receptor associated factor 7
chr1_+_210328244 0.38 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr3_-_123991352 0.37 ENST00000184183.8
ROPN1
rhophilin associated tail protein 1
chr22_+_35066136 0.36 ENST00000308700.6
ENST00000404699.7
ISX
intestine specific homeobox
chr3_-_115071333 0.35 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_174764407 0.34 ENST00000409219.5
ENST00000409542.5
CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
chr9_+_122371014 0.32 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr16_-_71577082 0.30 ENST00000355962.5
TAT
tyrosine aminotransferase
chr5_+_102808057 0.30 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr7_+_133253064 0.29 ENST00000393161.6
ENST00000253861.5
EXOC4
exocyst complex component 4
chr1_-_36397880 0.26 ENST00000315732.3
LSM10
LSM10, U7 small nuclear RNA associated
chr20_-_10420737 0.25 ENST00000649912.1
ENSG00000285723.1
novel protein
chr5_+_36596583 0.24 ENST00000680318.1
SLC1A3
solute carrier family 1 member 3
chr17_-_75667088 0.21 ENST00000578201.5
ENST00000423245.6
ENST00000317905.10
RECQL5
RecQ like helicase 5
chr11_-_102843597 0.20 ENST00000299855.10
MMP3
matrix metallopeptidase 3
chr2_-_174764436 0.20 ENST00000409323.1
ENST00000261007.9
ENST00000348749.9
ENST00000672640.1
CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
chr17_-_75667165 0.20 ENST00000584999.1
ENST00000420326.6
ENST00000340830.9
RECQL5
RecQ like helicase 5
chr1_+_110451132 0.18 ENST00000271331.4
PROK1
prokineticin 1
chr7_+_18496269 0.18 ENST00000432645.6
HDAC9
histone deacetylase 9
chr11_+_63838902 0.16 ENST00000377810.8
MARK2
microtubule affinity regulating kinase 2
chr6_-_43053832 0.15 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr1_-_45491150 0.15 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr5_-_145835285 0.14 ENST00000505416.5
ENST00000334744.8
ENST00000511435.1
PRELID2
PRELI domain containing 2
chr9_+_122370523 0.14 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr18_+_3252267 0.13 ENST00000536605.1
ENST00000580887.5
MYL12A
myosin light chain 12A
chr19_-_5903703 0.13 ENST00000586349.5
ENST00000585661.1
ENST00000592634.5
ENST00000418389.6
ENST00000308961.5
ENSG00000267740.5
NDUFA11
novel protein
NADH:ubiquinone oxidoreductase subunit A11
chr6_-_27814757 0.13 ENST00000333151.5
H2AC14
H2A clustered histone 14
chr1_-_149812359 0.13 ENST00000369167.2
ENST00000545683.1
H2BC18
H2B clustered histone 18
chrM_-_14669 0.12 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr4_-_68245683 0.12 ENST00000332644.6
TMPRSS11B
transmembrane serine protease 11B
chr2_-_175181663 0.11 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP5MC3
ATP synthase membrane subunit c locus 3
chr2_-_135530561 0.10 ENST00000536680.5
ENST00000401392.5
ZRANB3
zinc finger RANBP2-type containing 3
chr12_-_81598332 0.10 ENST00000443686.7
PPFIA2
PTPRF interacting protein alpha 2
chr7_+_129144691 0.07 ENST00000486685.3
TSPAN33
tetraspanin 33
chr1_-_155910881 0.05 ENST00000609492.1
ENST00000368322.7
RIT1
Ras like without CAAX 1
chr17_+_18183052 0.04 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr17_-_10657302 0.03 ENST00000583535.6
MYH3
myosin heavy chain 3
chr4_+_109827963 0.03 ENST00000317735.7
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr17_+_18183803 0.02 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr14_-_50561119 0.02 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr17_-_41382298 0.01 ENST00000394001.3
KRT34
keratin 34
chr18_+_3252208 0.01 ENST00000578562.6
MYL12A
myosin light chain 12A
chr11_-_102955705 0.01 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
MMP13
matrix metallopeptidase 13
chr6_+_26224192 0.00 ENST00000634733.1
H3C6
H3 clustered histone 6
chr2_-_51032091 0.00 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chrX_+_116170742 0.00 ENST00000371906.5
ENST00000681852.1
AGTR2
angiotensin II receptor type 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.7 GO:0097338 response to clozapine(GO:0097338)
0.2 1.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.2 0.6 GO:0036292 DNA rewinding(GO:0036292)
0.2 1.3 GO:0008218 bioluminescence(GO:0008218)
0.2 2.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.4 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.1 0.3 GO:0018032 protein amidation(GO:0018032)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.5 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 2.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.2 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.2 GO:0090050 peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.2 GO:0070697 activin receptor binding(GO:0070697)
0.1 0.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.3 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 1.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 PID IL3 PATHWAY IL3-mediated signaling events
0.0 2.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation