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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HOXB5

Z-value: 0.46

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.6 HOXB5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg38_v1_chr17_-_48593748_48593786-0.341.0e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_127822455 2.49 ENST00000265052.10
MGLL
monoglyceride lipase
chr19_+_49363923 0.78 ENST00000597546.1
DKKL1
dickkopf like acrosomal protein 1
chr11_-_6030758 0.71 ENST00000641900.1
OR56A1
olfactory receptor family 56 subfamily A member 1
chr16_-_84618067 0.70 ENST00000262428.5
COTL1
coactosin like F-actin binding protein 1
chr16_-_84618041 0.69 ENST00000564057.1
COTL1
coactosin like F-actin binding protein 1
chr5_-_35047935 0.54 ENST00000510428.1
ENST00000231420.11
AGXT2
alanine--glyoxylate aminotransferase 2
chr11_-_128522189 0.52 ENST00000526145.6
ETS1
ETS proto-oncogene 1, transcription factor
chr1_+_155610218 0.51 ENST00000649846.1
ENST00000245564.8
ENST00000368341.8
MSTO1
misato mitochondrial distribution and morphology regulator 1
chr3_-_165196689 0.51 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr11_-_57322197 0.48 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1
chr1_+_21981099 0.45 ENST00000400277.2
CELA3B
chymotrypsin like elastase 3B
chr1_+_4654732 0.45 ENST00000378190.7
AJAP1
adherens junctions associated protein 1
chr10_+_112376193 0.43 ENST00000433418.6
ENST00000356116.6
ENST00000354273.5
ACSL5
acyl-CoA synthetase long chain family member 5
chr19_+_49363730 0.42 ENST00000596402.1
ENST00000221498.7
DKKL1
dickkopf like acrosomal protein 1
chr5_-_161546970 0.38 ENST00000675303.1
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr14_-_23551729 0.37 ENST00000419474.5
ZFHX2
zinc finger homeobox 2
chr11_-_35418966 0.36 ENST00000531628.2
SLC1A2
solute carrier family 1 member 2
chr1_+_146938744 0.33 ENST00000617931.4
NBPF12
NBPF member 12
chr15_-_50765656 0.33 ENST00000261854.10
SPPL2A
signal peptide peptidase like 2A
chr11_-_35419098 0.31 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr12_-_101407727 0.29 ENST00000539055.5
ENST00000551688.1
ENST00000551671.5
ENST00000261636.13
ARL1
ADP ribosylation factor like GTPase 1
chr1_+_4654601 0.29 ENST00000378191.5
AJAP1
adherens junctions associated protein 1
chr3_+_51385282 0.28 ENST00000528157.7
MANF
mesencephalic astrocyte derived neurotrophic factor
chr7_-_102611591 0.28 ENST00000461209.5
RASA4
RAS p21 protein activator 4
chr15_+_41621492 0.27 ENST00000570161.6
MGA
MAX dimerization protein MGA
chr1_-_247458105 0.27 ENST00000641149.1
ENST00000641527.1
OR2B11
olfactory receptor family 2 subfamily B member 11
chr16_-_1771495 0.27 ENST00000564628.1
ENST00000219302.8
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr1_-_155688475 0.26 ENST00000405763.7
ENST00000368340.9
ENST00000454523.5
ENST00000368339.9
ENST00000443231.5
ENST00000347088.9
ENST00000361831.9
YY1AP1
YY1 associated protein 1
chr16_-_57971121 0.26 ENST00000251102.13
CNGB1
cyclic nucleotide gated channel subunit beta 1
chr9_-_127937800 0.23 ENST00000373110.4
ENST00000314392.13
DPM2
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
chr12_+_54561442 0.23 ENST00000550620.1
PDE1B
phosphodiesterase 1B
chr10_-_101843777 0.22 ENST00000356640.7
KCNIP2
potassium voltage-gated channel interacting protein 2
chrX_+_47218232 0.22 ENST00000457458.6
ENST00000522883.1
CDK16
cyclin dependent kinase 16
chr9_+_4662281 0.21 ENST00000381883.5
PLPP6
phospholipid phosphatase 6
chr17_-_44066595 0.21 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr14_-_102238439 0.21 ENST00000522534.5
MOK
MOK protein kinase
chr15_+_41621134 0.21 ENST00000566718.6
MGA
MAX dimerization protein MGA
chr12_-_52321395 0.20 ENST00000293670.3
KRT83
keratin 83
chr9_-_110208156 0.19 ENST00000400613.5
C9orf152
chromosome 9 open reading frame 152
chrM_+_12329 0.19 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr7_+_130381092 0.19 ENST00000484324.1
CPA1
carboxypeptidase A1
chr16_-_57971086 0.18 ENST00000564448.5
ENST00000311183.8
CNGB1
cyclic nucleotide gated channel subunit beta 1
chr1_-_36385872 0.18 ENST00000373129.7
STK40
serine/threonine kinase 40
chr17_+_48892761 0.18 ENST00000355938.9
ENST00000393366.7
ENST00000503641.5
ENST00000514808.5
ENST00000506855.1
ATP5MC1
ATP synthase membrane subunit c locus 1
chr1_-_36385887 0.18 ENST00000373130.7
ENST00000373132.4
STK40
serine/threonine kinase 40
chr3_+_130894382 0.17 ENST00000509662.5
ENST00000328560.12
ENST00000428331.6
ENST00000359644.7
ENST00000422190.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr18_+_34978244 0.17 ENST00000436190.6
MAPRE2
microtubule associated protein RP/EB family member 2
chr1_+_154257071 0.16 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2 like
chr7_+_5282935 0.15 ENST00000396872.8
ENST00000444741.5
ENST00000297195.8
ENST00000406453.3
SLC29A4
solute carrier family 29 member 4
chr8_+_117135259 0.15 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr1_-_155688727 0.15 ENST00000404643.5
ENST00000359205.9
ENST00000407221.5
ENST00000355499.9
YY1AP1
YY1 associated protein 1
chr1_-_155688294 0.15 ENST00000311573.9
YY1AP1
YY1 associated protein 1
chr1_-_145859061 0.15 ENST00000393045.7
PIAS3
protein inhibitor of activated STAT 3
chr1_-_145859043 0.14 ENST00000369298.5
PIAS3
protein inhibitor of activated STAT 3
chr11_+_63506046 0.14 ENST00000674247.1
LGALS12
galectin 12
chr18_-_35497591 0.14 ENST00000589273.1
ENST00000586489.5
INO80C
INO80 complex subunit C
chr1_+_235328959 0.13 ENST00000643758.1
ENST00000497327.1
TBCE
GGPS1
tubulin folding cofactor E
geranylgeranyl diphosphate synthase 1
chr12_-_6689359 0.13 ENST00000683879.1
ZNF384
zinc finger protein 384
chr12_-_6689244 0.13 ENST00000361959.7
ENST00000436774.6
ENST00000544482.1
ZNF384
zinc finger protein 384
chr14_+_21030509 0.13 ENST00000481535.5
TPPP2
tubulin polymerization promoting protein family member 2
chr3_-_195811857 0.13 ENST00000349607.8
ENST00000346145.8
MUC4
mucin 4, cell surface associated
chr6_-_31541937 0.12 ENST00000456662.5
ENST00000431908.5
ENST00000456976.5
ENST00000428450.5
ENST00000418897.5
ENST00000396172.6
ENST00000419020.1
ENST00000428098.5
DDX39B
DExD-box helicase 39B
chr15_-_74725370 0.11 ENST00000567032.5
ENST00000564596.5
ENST00000566503.1
ENST00000395049.8
ENST00000379727.8
ENST00000617691.4
ENST00000395048.6
CYP1A1
cytochrome P450 family 1 subfamily A member 1
chr20_+_8789517 0.11 ENST00000437439.2
PLCB1
phospholipase C beta 1
chr12_-_6689450 0.11 ENST00000355772.8
ENST00000417772.7
ENST00000319770.7
ENST00000396801.7
ZNF384
zinc finger protein 384
chr3_-_195811916 0.11 ENST00000463781.8
MUC4
mucin 4, cell surface associated
chr19_-_12156710 0.11 ENST00000455799.1
ENST00000439556.3
ZNF625
zinc finger protein 625
chr2_-_97589862 0.11 ENST00000258459.11
ENST00000438709.6
ANKRD36B
ankyrin repeat domain 36B
chr17_-_7207245 0.10 ENST00000649971.1
DLG4
discs large MAGUK scaffold protein 4
chrX_+_14529516 0.09 ENST00000218075.9
GLRA2
glycine receptor alpha 2
chr1_-_235328147 0.09 ENST00000264183.9
ENST00000418304.1
ENST00000349213.7
ARID4B
AT-rich interaction domain 4B
chr2_-_219308963 0.09 ENST00000423636.6
ENST00000442029.5
ENST00000412847.5
PTPRN
protein tyrosine phosphatase receptor type N
chr2_-_46941710 0.09 ENST00000409207.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr2_+_17541157 0.09 ENST00000406397.1
VSNL1
visinin like 1
chr19_-_13953302 0.08 ENST00000585607.1
ENST00000538517.6
ENST00000587458.1
ENST00000538371.6
PODNL1
podocan like 1
chr15_-_48811038 0.08 ENST00000380950.7
CEP152
centrosomal protein 152
chr14_+_21030201 0.06 ENST00000321760.11
ENST00000460647.6
ENST00000530140.6
ENST00000472458.5
TPPP2
tubulin polymerization promoting protein family member 2
chr11_-_125778788 0.06 ENST00000436890.2
PATE2
prostate and testis expressed 2
chr11_-_125778818 0.06 ENST00000358524.8
PATE2
prostate and testis expressed 2
chr17_+_6776209 0.06 ENST00000321535.5
FBXO39
F-box protein 39
chr6_-_31542339 0.06 ENST00000458640.5
DDX39B
DExD-box helicase 39B
chr20_-_6054026 0.03 ENST00000378858.5
LRRN4
leucine rich repeat neuronal 4
chr12_+_57591158 0.03 ENST00000422156.7
ENST00000354947.10
ENST00000540759.6
ENST00000551772.5
ENST00000550465.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr19_-_49763295 0.03 ENST00000246801.8
TSKS
testis specific serine kinase substrate
chr1_+_157993601 0.03 ENST00000359209.11
KIRREL1
kirre like nephrin family adhesion molecule 1
chr19_-_42220109 0.03 ENST00000595337.5
DEDD2
death effector domain containing 2
chrX_+_48521817 0.02 ENST00000446158.5
ENST00000414061.1
EBP
EBP cholestenol delta-isomerase
chr1_-_161223408 0.01 ENST00000491350.1
APOA2
apolipoprotein A2
chr1_-_161223559 0.01 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr12_-_7665897 0.00 ENST00000229304.5
APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr2_+_17540670 0.00 ENST00000451533.5
ENST00000295156.9
VSNL1
visinin like 1
chr1_+_24502320 0.00 ENST00000538532.6
ENST00000618490.4
RCAN3
RCAN family member 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.5 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.1 0.7 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.7 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.5 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.7 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.0 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.1 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 1.4 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.5 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.0 GO:0060694 regulation of cholesterol transporter activity(GO:0060694)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 1.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.5 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.7 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.5 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.1 0.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.1 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.2 GO:0046923 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0030395 lactose binding(GO:0030395)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.1 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA