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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HOXB6_PRRX2
Z-value: 2.31
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB6 | hg38_v1_chr17_-_48604959_48605000 | -0.32 | 1.2e-01 | Click! |
| PRRX2 | hg38_v1_chr9_+_129665603_129665672 | -0.32 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 96.7 | GO:0007286 | spermatid development(GO:0007286) |
| 0.2 | 62.7 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.8 | 52.0 | GO:0072189 | ureter development(GO:0072189) |
| 6.0 | 47.8 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 3.9 | 42.5 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 3.8 | 26.7 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.7 | 25.2 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.3 | 24.6 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.4 | 22.4 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.9 | 18.7 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 91.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 64.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.6 | 42.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 39.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 34.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 33.9 | GO:0030027 | lamellipodium(GO:0030027) |
| 1.2 | 26.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 2.3 | 20.9 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 20.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.3 | 15.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 111.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.1 | 93.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 2.7 | 57.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 2.3 | 43.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 1.7 | 26.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.8 | 24.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 21.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.1 | 20.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 18.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.5 | 14.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 93.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.0 | 90.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.4 | 50.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.8 | 47.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.4 | 23.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 12.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 12.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 11.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 11.0 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 8.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 95.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.1 | 42.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.8 | 30.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 13.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 12.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.5 | 11.8 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 11.1 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 10.0 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.2 | 10.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 10.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |