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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for HOXB8
Z-value: 0.87
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Transcription factors associated with HOXB8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB8 | hg38_v1_chr17_-_48613468_48613522 | -0.15 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_122621011 Show fit | 1.69 |
ENST00000611104.2
ENST00000648588.1 |
interleukin 21 |
|
| chr5_+_157269317 Show fit | 1.35 |
ENST00000618329.4
|
cytoplasmic FMR1 interacting protein 2 |
|
| chr1_+_86547070 Show fit | 1.16 |
ENST00000370563.3
|
chloride channel accessory 4 |
|
| chr9_-_83267230 Show fit | 1.14 |
ENST00000328788.5
|
FERM domain containing 3 |
|
| chr3_+_148827800 Show fit | 1.10 |
ENST00000282957.9
ENST00000468341.1 |
carboxypeptidase B1 |
|
| chr15_+_76336755 Show fit | 1.04 |
ENST00000290759.9
|
ISL LIM homeobox 2 |
|
| chr19_-_14835162 Show fit | 0.96 |
ENST00000322301.5
|
olfactory receptor family 7 subfamily A member 5 |
|
| chr10_-_88952763 Show fit | 0.95 |
ENST00000224784.10
|
actin alpha 2, smooth muscle |
|
| chr7_-_116030735 Show fit | 0.89 |
ENST00000393485.5
|
transcription factor EC |
|
| chr20_-_56497608 Show fit | 0.86 |
ENST00000617620.1
|
glucosaminyl (N-acetyl) transferase family member 7 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 1.7 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.2 | 1.3 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.1 | 1.3 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 1.2 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 1.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.3 | 1.0 | GO:0021524 | visceral motor neuron differentiation(GO:0021524) |
| 0.1 | 1.0 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.2 | 0.9 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.1 | 0.9 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 0.9 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.7 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 0.6 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 0.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.5 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.4 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 1.7 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 1.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 1.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.1 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 1.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 1.0 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
| 0.2 | 0.9 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.0 | 0.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.2 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.3 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 1.2 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.7 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.6 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.5 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.5 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |